Swipe om te navigeren naar een ander artikel
Identification of gene x environment interactions (GxE) for attention-deficit hyperactivity disorder (ADHD) is a crucial component to understanding the mechanisms underpinning the disorder, as prior work indicates large genetic influences and numerous environmental risk factors. Building on prior research, children’s appraisals of self-blame were examined as a psychosocial moderator of latent etiological influences on ADHD via biometric twin models, which provide an omnibus test of GxE while managing the potential confound of gene-environment correlation. Participants were 246 twin pairs (total n = 492) ages 6–16 years. ADHD behaviors were assessed via mother report on the Child Behavior Checklist. To assess level of self-blame, each twin completed the Children’s Perception of Inter-parental Conflict scale. Two biometric GxE models were fit to the data. The first model revealed a significant decrease in genetic effects and a significant increase in unique environmental influences on ADHD with increasing levels of self-blame. These results generally persisted even after controlling for confounding effects due to gene-environment correlation in the second model. Results suggest that appraisals of self-blame in relation to inter-parental conflict may act as a key moderator of etiological contributions to ADHD.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Achenbach, T., & Rescorla, L. A. (2001). Manual for the Child Behavior Checklist and 2001 profile. Burlington: University of Vermont, Department of Psychiatry.
Burt, S. A. (2008). Gene-environment interactions and their impact on the development of personality traits. Psychiatry, 7, 507–510. CrossRef
Cummings, E. M., & Davies, P. T. (1994). Children and marital conflict: The impact of marital dispute and resolution. New York: The Guilford Press.
Cummings, E. M., Davies, P. T., & Simpson, K. S. (1994). Marital conflict, gender, children’s appraisals, and coping efficacy as mediators of child adjustment. Journal of Family Psychology, 8, 141–149. CrossRef
Cummings, E. M., Goeke-Morey, M. C., & Papp, L. M. (2004). Everyday marital conflict and child aggression. Journal of Abnormal Child Psychology, 32, 191–202.
Harold, G. T., Shelton, K. H., Goeke-Morey, M. C., & Cummings, E. M. (2004). Marital conflict, child emotional security about family relationships, and child adjustment. Social Development, 13, 350–376. CrossRef
Hudziak, J. J., Copeland, W., Stanger, C., & Wadsworth, M. (2004). Screening for DSM-IV externalizing disorders with the Child Behavior Checklist: a Receiver-Operating characteristic analysis. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 1299–1307. CrossRef
Kaprio, J., Sarna, S., Koskenvuo, M., & Rantasalo, I. (1978). The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures, and research program. Progress in Clinical and Biological Research, 24, 179–184. PubMed
Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M. B., Craddock, N., et al. (2008). Testing for gene x environment effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics: Part B Neuropsychiatric Genetics, 147B, 49–53. CrossRef
Lehn, H., Derks, E. M., Hudziak, J. J., Heutink, P., van Beijsterveldt, T. C., & Boomsma, D. I. (2007). Attention problems and attention-deficit/hyperactivity disorder in discordant and concordant monozygotic twins: evidence of environmental mediators. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 83–91. PubMedCrossRef
Lichentenstein, P., DeFaire, U., Floderus, B., Svartengren, W., Svedberg, P., & Pedersen, N. L. (2002). The Swedish Twin Registry: a unique resource for clinical, epidemiological, and genetic studies. Journal of Internal Medicine, 252, 181–183. CrossRef
Little, R. J. A., & Rubin, D. B. (1987). Statistical analysis with missing data. New York: Wiley.
Neale, M., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statisical modeling (5th ed.). Richmond: Department of Psychiatry.
Nigg, J. T. (2006). What causes ADHD? Understanding what goes wrong and why. New York: The Guilford Press.
Nigg, J. T., Hinshaw, S. P., & Huang-Pollock, C. (2006). Disorders of attention and impulse regulation. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology, volume 3: Risk, disorder, and adaptation (2nd ed., pp. 358–403). Hoboken: Wiley.
Nigg, J. T., Nikolas, M., Knotterus, G. M., Cavanagh, K., & Friderici, K. (2010). Confirmation and extension of blood lead with attention-deficit hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. Journal of Child Psychology and Psychiatry, 51, 58–65. PubMedCrossRef
Plomin, R., DeFries, J. C., McClearn, G. E., & McGruffin, P. (2008). Behavioral Genetics (Rev. 5th Edition). New York: Worth Publishers and W.H. Freeman and Company.
Purcell, S. (2002). Variance component models for gene-environment interaction in twin analysis. Twin Research, 5, 554–571. PubMed
Retz, W., Freitag, C. M., Retz-Junginger, P., Wenzler, D., Schneider, M., Kissling, C., et al. (2008). A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: interaction with adverse childhood environment. Psychiatry Research, 158, 123–131. PubMedCrossRef
Rietveld, M. J., van der Valk, J. C., Bongers, I. L., Stroet, T. M., Slagboom, P. E., & Boomsma, D. I. (2000). Zygosity in young twins by parent report. Twin Research, 3, 134–141. PubMed
Todd, R. D., & Neuman, R. J. (2007). Gene-environment interactions in the development of combined type ADHD: development of a synapse-based model. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B, 971–975. CrossRef
Torgesen, J. K., Wagner, R. K., & Rashotte, C. A. (1999). Test of word reading efficiency. Austin: PRO-ED.
Whalen, C. K., & Henker, B. (1999). The child with attention-deficit hyperactivity disorder in family contexts. In H. C. Quay & A. E. Hogan (Eds.), Handbook of disruptive behavior disorders (pp. 139–155). New York: Kluwer Academic/Plenum. CrossRef
- Youth Appraisals of Inter-parental Conflict and Genetic and Environmental Contributions to Attention-Deficit Hyperactivity Disorder: Examination of GxE Effects in a Twin Sample
Kelly L. Klump
S. Alexandra Burt
- Springer US