Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

01-09-2016 | Uitgave 9/2016

Quality of Life Research 9/2016

Xerostomia health-related quality of life: NRG oncology RTOG 0537

Tijdschrift:
Quality of Life Research > Uitgave 9/2016
Auteurs:
Gwen Wyatt, Stephanie L. Pugh, Raimond K. W. Wong, Stephen Sagar, MD Anurag K. Singh, Shlomo A. Koyfman, Phuc F. Nguyen-Tân, Sue S. Yom, Francis S. Cardinale, Khalil Sultanem, Ian Hodson, Greg A. Krempl, Barbara Lukaszczyk, Alexander M. Yeh, Lawrence Berk

Abstract

Purpose

The purpose of this secondary analysis was to determine change in overall health-related quality of life (HRQOL) based on patient data obtained from NRG Oncology RTOG 0537 as measured by the RTOG-modified University of Washington Head and Neck Symptom Score (RM-UWHNSS).

Methods

A multi-site prospective randomized clinical trial design stratified 137 patients with post-radiation therapy xerostomia according to prior pilocarpine (PC) treatment and time after radiation therapy and/or chemotherapy and randomized patients into two groups. Patients were assigned to acupuncture or PC. Twenty-four sessions of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) were administered over 12 weeks, or oral PC (5 mg) three times daily over the same 12 weeks. The RM-UWHNSS was administered at baseline and at 4, 6, 9, and 15 months after the date of randomization.

Results

There were no between-arm differences in change scores on the RM-UWHNSS in the individual items, total score, or factor scores. For statistical modeling, race and time were significant for all outcomes (total and factor scores), while treatment arm was not significant. The ALTENS arm showed greater yet nonsignificant improvement in outcomes compared to the PC arm.

Conclusion

Although no significant treatment differences were seen in this trial, patients receiving ALTENS consistently had lower scores, indicating better function, as compared to those receiving PC. Radiation-induced xerostomia improved over time for all patients.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Literatuur
Over dit artikel

Andere artikelen Uitgave 9/2016

Quality of Life Research 9/2016 Naar de uitgave