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Gepubliceerd in: Quality of Life Research 9/2016

01-09-2016

Xerostomia health-related quality of life: NRG oncology RTOG 0537

Auteurs: Gwen Wyatt, Stephanie L. Pugh, Raimond K. W. Wong, Stephen Sagar, MD Anurag K. Singh, Shlomo A. Koyfman, Phuc F. Nguyen-Tân, Sue S. Yom, Francis S. Cardinale, Khalil Sultanem, Ian Hodson, Greg A. Krempl, Barbara Lukaszczyk, Alexander M. Yeh, Lawrence Berk

Gepubliceerd in: Quality of Life Research | Uitgave 9/2016

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Abstract

Purpose

The purpose of this secondary analysis was to determine change in overall health-related quality of life (HRQOL) based on patient data obtained from NRG Oncology RTOG 0537 as measured by the RTOG-modified University of Washington Head and Neck Symptom Score (RM-UWHNSS).

Methods

A multi-site prospective randomized clinical trial design stratified 137 patients with post-radiation therapy xerostomia according to prior pilocarpine (PC) treatment and time after radiation therapy and/or chemotherapy and randomized patients into two groups. Patients were assigned to acupuncture or PC. Twenty-four sessions of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) were administered over 12 weeks, or oral PC (5 mg) three times daily over the same 12 weeks. The RM-UWHNSS was administered at baseline and at 4, 6, 9, and 15 months after the date of randomization.

Results

There were no between-arm differences in change scores on the RM-UWHNSS in the individual items, total score, or factor scores. For statistical modeling, race and time were significant for all outcomes (total and factor scores), while treatment arm was not significant. The ALTENS arm showed greater yet nonsignificant improvement in outcomes compared to the PC arm.

Conclusion

Although no significant treatment differences were seen in this trial, patients receiving ALTENS consistently had lower scores, indicating better function, as compared to those receiving PC. Radiation-induced xerostomia improved over time for all patients.
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Metagegevens
Titel
Xerostomia health-related quality of life: NRG oncology RTOG 0537
Auteurs
Gwen Wyatt
Stephanie L. Pugh
Raimond K. W. Wong
Stephen Sagar
MD Anurag K. Singh
Shlomo A. Koyfman
Phuc F. Nguyen-Tân
Sue S. Yom
Francis S. Cardinale
Khalil Sultanem
Ian Hodson
Greg A. Krempl
Barbara Lukaszczyk
Alexander M. Yeh
Lawrence Berk
Publicatiedatum
01-09-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1255-0

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