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Journal of Autism and Developmental Disorders

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22-02-2016 | Original Paper

Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder

Auteurs: V. M. Vogan, B. R. Morgan, R. C. Leung, E. Anagnostou, K. Doyle-Thomas, M. J. Taylor

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2016

Abstract

Diffusion tensor imaging studies show white matter (WM) abnormalities in children with autism spectrum disorder (ASD). However, investigations are often limited by small samples, particularly problematic given the heterogeneity of ASD. We explored WM using DTI in a large sample of 130 children and adolescents (7–15 years) with and without ASD, whether age-related changes differed between ASD and control groups, and the relation between DTI measures and ASD symptomatology. Reduced fractional anisotropy and axial diffusivity were observed in ASD in numerous WM tracts, including the corpus callosum and thalamocortical fibres—tracts crucial for interhemispheric connectivity and higher order information processing. Widespread WM compromise in ASD is consistent with the view that ASD is a disorder of generalized complex information processing.

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Titel: Widespread White Matter Differences in Children and Adolescents with Autism Spectrum Disorder
Auteurs: V. M. Vogan
B. R. Morgan
R. C. Leung
E. Anagnostou
K. Doyle-Thomas
M. J. Taylor
Publicatiedatum: 22-02-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-016-2744-2

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