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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2019

20-05-2016 | Original Paper

Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders

Auteurs: Jacqueline Fitzgerald, Louise Gallagher, Jane McGrath

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2019

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Abstract

Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder.
vorige artikel A Comparison Between Caregiver-Reported Anxiety and Other Emotional and Behavioral Difficulties in Children and Adolescents with Autism Spectrum Disorders Attending Specialist or Mainstream Schools
volgende artikel Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder
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Literatuur
Aghajani, M., Veer, I. M., van Lang, N. D., Meens, P. H., van den Bulk, B. G., Rombouts, S. A., et al. (2014). Altered white-matter architecture in treatment-naive adolescents with clinical depression. Psychological Medicine, 44, 2287–2298. CrossRefPubMed
Alaerts, K., Woolley, D. G., Steyaert, J., Di Martino, A., Swinnen, S. P., & Wenderoth, N. (2014). Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism. Social Cognitive and Affective Neuroscience, 9, 1589–1600. CrossRefPubMed
Alexander, A. L., Lee, J. E., Lazar, M., & Field, A. S. (2007). Diffusion tensor imaging of the brain. Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics, 4, 316–329. CrossRef
Ameis, S. H., Fan, J., Rockel, C., Voineskos, A. N., Lobaugh, N. J., Soorya, L., et al. (2011). Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: A diffusion tensor imaging study. PLoS ONE, 6, e28044. CrossRefPubMedPubMedCentral
APA. (2013). Diagnostic and statistical manual of mental disorders: DSM-V. In APA (Ed.), 5th ed. Arlington, VA: American Psychiatric Association.
Asato, M. R., Terwilliger, R., Woo, J., & Luna, B. (2010). White matter development in adolescence: A DTI study. Cerebral Cortex, 20, 2122–2131. CrossRefPubMed
Bach, M., Laun, F. B., Leemans, A., Tax, C. M., Biessels, G. J., Stieltjes, B., & Maier-Hein, K. H. (2014). Methodological considerations on tract-based spatial statistics (TBSS). NeuroImage, 100, 358–369. CrossRefPubMed
Bakhtiari, R., Zurcher, N. R., Rogier, O., Russo, B., Hippolyte, L., Granziera, C., et al. (2012). Differences in white matter reflect atypical developmental trajectory in autism: A tract-based spatial statistics study. NeuroImage Clinical, 1, 48–56. CrossRefPubMedPubMedCentral
Barnea-Goraly, N., Lotspeich, L. J., & Reiss, A. L. (2010). Similar white matter aberrations in children with autism and their unaffected siblings: A diffusion tensor imaging study using tract-based spatial statistics. Archives of General Psychiatry, 67, 1052–1060. CrossRefPubMed
Bava, S., Thayer, R., Jacobus, J., Ward, M., Jernigan, T. L., & Tapert, S. F. (2010). Longitudinal characterization of white matter maturation during adolescence. Brain Research, 1327, 38–46. CrossRefPubMedPubMedCentral
Billeci, L., Calderoni, S., Tosetti, M., Catani, M., & Muratori, F. (2012). White matter connectivity in children with autism spectrum disorders: A tract-based spatial statistics study. BMC Neurology, 12, 148. CrossRefPubMedPubMedCentral
Bode, M. K., Mattila, M. L., Kiviniemi, V., Rahko, J., Moilanen, I., Ebeling, H., et al. (2011). White matter in autism spectrum disorders—evidence of impaired fiber formation. Acta Radiologica, 52, 1169–1174. CrossRefPubMed
Boomsma, A., Van Lang, N. D., De Jonge, M. V., De Bildt, A. A., Van Engeland, H., & Minderaa, R. B. (2008). A new symptom model for autism cross-validated in an independent sample. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49, 809–816. CrossRef
Catani, M. (2006). Diffusion tensor magnetic resonance imaging tractography in cognitive disorders. Current Opinion in Neurology, 19, 599–606. CrossRefPubMed
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002). Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage, 17, 77–94. CrossRefPubMed
Catani, M., Jones, D. K., & Ffytche, D. H. (2005). Perisylvian language networks of the human brain. Annals of Neurology, 57, 8–16. CrossRef
Catani, M., & Thiebaut de Schotten, M. (2008). A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex; A Journal Devoted to the Study of the Nervous System and Behavior, 44, 1105–1132. CrossRefPubMed
Chaddock-Heyman, L., Erickson, K. I., Voss, M. W., Powers, J. P., Knecht, A. M., Pontifex, M. B., et al. (2013). White matter microstructure is associated with cognitive control in children. Biological Psychology, 94, 109–115. CrossRefPubMedPubMedCentral
Chang, L. C., Jones, D. K., & Pierpaoli, C. (2005). RESTORE: Robust estimation of tensors by outlier rejection. Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine/Society of Magnetic Resonance in Medicine, 53, 1088–1095. CrossRef
Cheng, Y., Chou, K. H., Chen, I. Y., Fan, Y. T., Decety, J., & Lin, C. P. (2010). Atypical development of white matter microstructure in adolescents with autism spectrum disorders. NeuroImage, 50, 873–882. CrossRefPubMed
Cheon, K. A., Kim, Y. S., Oh, S. H., Park, S. Y., Yoon, H. W., Herrington, J., et al. (2011). Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: A Diffusion Tensor Imaging study. Brain Research, 1417, 77–86. CrossRefPubMed
Cherkassky, V. L., Kana, R. K., Keller, T. A., & Just, M. A. (2006). Functional connectivity in a baseline resting-state network in autism. Neuroreport, 17, 1687–1690. CrossRefPubMed
Clayden, J. D., Jentschke, S., Munoz, M., Cooper, J. M., Chadwick, M. J., Banks, T., et al. (2012). Normative development of white matter tracts: Similarities and differences in relation to age, gender, and intelligence. Cerebral Cortex, 22, 1738–1747. CrossRefPubMed
Damarla, S. R., Keller, T. A., Kana, R. K., Cherkassky, V. L., Williams, D. L., Minshew, N. J., & Just, M. A. (2010). Cortical underconnectivity coupled with preserved visuospatial cognition in autism: Evidence from an fMRI study of an embedded figures task. Autism Research: Official Journal of the International Society for Autism Research, 3, 273–279. CrossRef
Ellison-Wright, I., Nathan, P. J., Bullmore, E. T., Zaman, R., Dudas, R. B., Agius, M., et al. (2014). Distribution of tract deficits in schizophrenia. BMC Psychiatry, 14, 99. CrossRefPubMedPubMedCentral
Fitzgerald, J., Johnson, K., Kehoe, E., Bokde, A. L. W., Garavan, H., Gallagher, L., & McGrath, J. (2015). Disrupted functional connectivity in dorsal and ventral attention networks during attention orienting in autism spectrum disorders. Autism Research: Official Journal of the International Society for Autism Research, 8, 136–152. CrossRef
Frazier, T. W., Youngstrom, E. A., Kubu, C. S., Sinclair, L., & Rezai, A. (2008). Exploratory and confirmatory factor analysis of the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 38, 474–480. CrossRefPubMed
Georgiades, S., Szatmari, P., Boyle, M., Hanna, S., Duku, E., Zwaigenbaum, L., et al. (2013). Investigating phenotypic heterogeneity in children with autism spectrum disorder: A factor mixture modeling approach. Journal of Child Psychology and Psychiatry, and Allied Disciplines 54, 206–215. CrossRefPubMed
Giannelli, M., Cosottini, M., Michelassi, M. C., Lazzarotti, G., Belmonte, G., Bartolozzi, C., & Lazzeri, M. (2010). Dependence of brain DTI maps of fractional anisotropy and mean diffusivity on the number of diffusion weighting directions. J Appl Clin Med Phys, 11, 2927.
Gibbard, C. R., Ren, J., Seunarine, K. K., Clayden, J. D., Skuse, D. H., & Clark, C. A. (2013). White matter microstructure correlates with autism trait severity in a combined clinical-control sample of high-functioning adults. NeuroImage Clinical, 3, 106–114. CrossRefPubMedPubMedCentral
Giorgio, A., Watkins, K. E., Chadwick, M., James, S., Winmill, L., Douaud, G., et al. (2010). Longitudinal changes in grey and white matter during adolescence. NeuroImage, 49, 94–103. CrossRefPubMed
Giorgio, A., Watkins, K. E., Douaud, G., James, A. C., James, S., De Stefano, N., et al. (2008). Changes in white matter microstructure during adolescence. NeuroImage, 39, 52–61. CrossRefPubMed
Holleran, L., Ahmed, M., Anderson-Schmidt, H., McFarland, J., Emsell, L., Leemans, A., et al. (2014). Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 39, 944–954. CrossRef
Jou, R. J., Mateljevic, N., Kaiser, M. D., Sugrue, D. R., Volkmar, F. R., & Pelphrey, K. A. (2011). Structural neural phenotype of autism: Preliminary evidence from a diffusion tensor imaging study using tract-based spatial statistics. American Journal of Neuroradiology, 32, 1607–1613. CrossRefPubMed
Jou, R. J., Reed, H. E., Kaiser, M. D., Voos, A. C., Volkmar, F. R., & Pelphrey, K. A. (2016). White matter abnormalities in autism and unaffected siblings. The Journal of Neuropsychiatry and Clinical Neurosciences, 28, 49–55. CrossRefPubMed
Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951–961. CrossRefPubMed
Kana, R.K., Keller, T.A., Cherkassky, V.L., Minshew, N.J., Just, M.A., 2006. Sentence comprehension in autism: thinking in pictures with decreased functional connectivity. Brain: A Journal of Neurology 129, 2484-2493. CrossRef
Keedwell, P. A., Chapman, R., Christiansen, K., Richardson, H., Evans, J., & Jones, D. K. (2012). Cingulum white matter in young women at risk of depression: The effect of family history and anhedonia. Biological Psychiatry, 72, 296–302. CrossRefPubMed
Kikinis, Z., Asami, T., Bouix, S., Finn, C. T., Ballinger, T., Tworog-Dube, E., et al. (2012). Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: A pilot study. Schizophrenia Research, 141, 35–39. CrossRefPubMedPubMedCentral
Kim, S. H., & Lord, C. (2010). Restricted and repetitive behaviors in toddlers and preschoolers with autism spectrum disorders based on the Autism Diagnostic Observation Schedule (ADOS). Autism research: Official Journal of the International Society for Autism Research, 3, 162–173. CrossRef
Kleinhans, N. M., Pauley, G., Richards, T., Neuhaus, E., Martin, N., Corrigan, N. M., et al. (2012). Age-related abnormalities in white matter microstructure in autism spectrum disorders. Brain Research, 1479, 1–16. CrossRefPubMedPubMedCentral
Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C. et al. (2008). Abnormal functional connectivity in autism spectrum disorders during face processing. Brain: A Journal of Neurology 131, 1000–1012. CrossRef
Kumar, A., Sundaram, S. K., Sivaswamy, L., Behen, M. E., Makki, M. I., Ager, J., et al. (2010). Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder. Cerebral Cortex, 20, 2103–2113. CrossRefPubMed
Lau, Y. C., Hinkley, L. B., Bukshpun, P., Strominger, Z. A., Wakahiro, M. L., Baron-Cohen, S., et al. (2013). Autism traits in individuals with agenesis of the corpus callosum. Journal of Autism and Developmental Disorders, 43, 1106–1118. CrossRefPubMedPubMedCentral
Lebel, C., & Beaulieu, C. (2011). Longitudinal development of human brain wiring continues from childhood into adulthood. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 31, 10937–10947. CrossRef
Lebel, C., Walker, L., Leemans, A., Phillips, L., & Beaulieu, C. (2008). Microstructural maturation of the human brain from childhood to adulthood. NeuroImage, 40, 1044–1055. CrossRefPubMed
Leemans, A., Jeurissen, B., Sijbers, J., & Jones, D. K. (2009). ExploreDTI: A graphical toolbox for processing, analyzing and visualizing diffusion MR data. In Proceedings of the 17th annual meeting of international society for magnetic resonance in medicine, Hawaii, USA, p 3536.
Leemans, A., & Jones, D. K. (2009). The B-matrix must be rotated when correcting for subject motion in DTI data. Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine/Society of Magnetic Resonance in Medicine, 61, 1336–1349. CrossRef
Liu, X. Q., Georgiades, S., Duku, E., Thompson, A., Devlin, B., Cook, E. H., et al. (2011). Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 50(687–696), e613.
Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. CrossRefPubMed
Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. CrossRefPubMed
Mandy, W. P., Charman, T., & Skuse, D. H. (2012). Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 41–50. CrossRefPubMed
Mason, R. A., Williams, D. L., Kana, R. K., Minshew, N., & Just, M. A. (2008). Theory of Mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. Neuropsychologia, 46, 269–280. CrossRefPubMed
McGrath, J., Johnson, K., Ecker, C., O’Hanlon, E., Gill, M., Gallagher, L., & Garavan, H. (2012). Atypical visuospatial processing in autism: Insights from functional connectivity analysis. Autism Research: Official Journal of the International Society for Autism Research, 5, 314–330. CrossRef
McGrath, J., Johnson, K., O’Hanlon, E., Garavan, H., Leemans, A., & Gallagher, L. (2013). Abnormal functional connectivity during visuospatial processing is associated with disrupted organisation of white matter in autism. Frontiers in Human Neuroscience, 7, 434. CrossRefPubMedPubMedCentral
Mizuno, A., Villalobos, M. E., Davies, M. M., Dahl, B. C., & Muller, R. A. (2006). Partially enhanced thalamocortical functional connectivity in autism. Brain Research, 1104, 160–174. CrossRefPubMed
Mostofsky, S. H., Powell, S. K., Simmonds, D. J., Goldberg, M. C., Caffo, B., & Pekar, J. J. (2009). Decreased connectivity and cerebellar activity in autism during motor task performance. Brain: A Journal of Neurology 132, 2413–2425. CrossRef
Nagae, L. M., Zarnow, D. M., Blaskey, L., Dell, J., Khan, S. Y., Qasmieh, S., et al. (2012). Elevated mean diffusivity in the left hemisphere superior longitudinal fasciculus in autism spectrum disorders increases with more profound language impairment. American Journal of Neuroradiology, 33, 1720–1725. CrossRefPubMed
Nair, A., Treiber, J. M., Shukla, D. K., Shih, P., & Muller, R. A. (2013). Impaired thalamocortical connectivity in autism spectrum disorder: A study of functional and anatomical connectivity. Brain: A Journal of Neurology 136, 1942–1955. CrossRef
Noble, K. G., Korgaonkar, M. S., Grieve, S. M., & Brickman, A. M. (2013). Higher education is an age-independent predictor of white matter integrity and cognitive control in late adolescence. Developmental Science, 16, 653–664. CrossRefPubMedPubMedCentral
Noriuchi, M., Kikuchi, Y., Yoshiura, T., Kira, R., Shigeto, H., Hara, T., et al. (2010). Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder. Brain Research, 1362, 141–149. CrossRefPubMed
Prigge, M. B., Lange, N., Bigler, E. D., Merkley, T. L., Neeley, E. S., Abildskov, T. J., et al. (2013). Corpus callosum area in children and adults with autism. Research in Autism Spectrum Disorders, 7, 221–234. CrossRefPubMed
Qiu, D., Tan, L. H., Zhou, K., & Khong, P. L. (2008). Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: Voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development. NeuroImage, 41, 223–232. CrossRefPubMed
Rudrauf, D., Mehta, S., & Grabowski, T. J. (2008). Disconnection’s renaissance takes shape: Formal incorporation in group-level lesion studies. Cortex; A Journal Devoted to the Study of the Nervous System and Behavior, 44, 1084–1096. CrossRefPubMed
Shih, P., Keehn, B., Oram, J. K., Leyden, K. M., Keown, C. L., & Muller, R. A. (2011). Functional differentiation of posterior superior temporal sulcus in autism: A functional connectivity magnetic resonance imaging study. Biological Psychiatry, 70, 270–277. CrossRefPubMedPubMedCentral
Shukla, D. K., Keehn, B., & Muller, R. A. (2011). Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52, 286–295. CrossRefPubMed
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., et al. (2006). Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. NeuroImage, 31, 1487–1505. CrossRefPubMed
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E., Johansen-Berg, H., et al. (2004). Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage, 23(Suppl 1), S208–219. CrossRef
Smith, S. M., & Nichols, T. E. (2009). Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage, 44, 83–98. CrossRefPubMed
Solomon, M., Ozonoff, S. J., Ursu, S., Ravizza, S., Cummings, N., Ly, S., & Carter, C. S. (2009). The neural substrates of cognitive control deficits in autism spectrum disorders. Neuropsychologia, 47, 2515–2526. CrossRefPubMedPubMedCentral
Song, S. K., Sun, S. W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002). Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. NeuroImage, 17, 1429–1436. CrossRefPubMed
Song, S. K., Yoshino, J., Le, T. Q., Lin, S. J., Sun, S. W., Cross, A. H., & Armstrong, R. C. (2005). Demyelination increases radial diffusivity in corpus callosum of mouse brain. NeuroImage, 26, 132–140. CrossRefPubMed
Urger, S. E., De Bellis, M. D., Hooper, S. R., Woolley, D. P., Chen, S. D., & Provenzale, J. (2015). The superior longitudinal fasciculus in typically developing children and adolescents: Diffusion tensor imaging and neuropsychological correlates. Journal of Child Neurology, 30, 9–20. CrossRefPubMed
Vissers, M. E., Cohen, M. X., & Geurts, H. M. (2012). Brain connectivity and high functioning autism: A promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neuroscience and Biobehavioral Reviews, 36, 604–625. CrossRefPubMed
Wang, Y., Adamson, C., Yuan, W., Altaye, M., Rajagopal, A., Byars, A. W., & Holland, S. K. (2012a). Sex differences in white matter development during adolescence: A DTI study. Brain Research, 1478, 1–15. CrossRefPubMedPubMedCentral
Wang, Y., Horst, K. K., Kronenberger, W. G., Hummer, T. A., Mosier, K. M., Kalnin, A. J., et al. (2012b). White matter abnormalities associated with disruptive behavior disorder in adolescents with and without attention-deficit/hyperactivity disorder. Psychiatry Research, 202, 245–251. CrossRefPubMed
Weinstein, M., Ben-Sira, L., Levy, Y., Zachor, D. A., Ben Itzhak, E., Artzi, M., et al. (2011a). Abnormal white matter integrity in young children with autism. Human Brain Mapping, 32, 534–543. CrossRefPubMed
Weinstein, M., Ben-Sira, L., Levy, Y., Zachor, D. A., Itzhak, E. B., Artzi, M., et al. (2011b). Abnormal white matter integrity in young children with autism. Human Brain Mapping, 32, 534–543. CrossRefPubMed
Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., & Nichols, T. E. (2014). Permutation inference for the general linear model. NeuroImage, 92, 381–397. CrossRefPubMedPubMedCentral
Zuo, N., Fang, J., Lv, X., Zhou, Y., Hong, Y., Li, T., et al. (2012). White matter abnormalities in major depression: A tract-based spatial statistics and rumination study. PloS ONE, 7, e37561. CrossRefPubMedPubMedCentral
Metagegevens
Titel
Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders
Auteurs
Jacqueline Fitzgerald
Louise Gallagher
Jane McGrath
Publicatiedatum
20-05-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-2803-8

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