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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2019

20-05-2016 | Original Paper

Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders

Auteurs: Jacqueline Fitzgerald, Louise Gallagher, Jane McGrath

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2019

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Abstract

Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder.
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Metagegevens
Titel
Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders
Auteurs
Jacqueline Fitzgerald
Louise Gallagher
Jane McGrath
Publicatiedatum
20-05-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-016-2803-8