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29-03-2019 | OriginalPaper

Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder

Auteurs: Elizabeth Aaron, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M. D. Carneiro, Suma Jacob, Matthew Mosconi, Ghanshyam N. Pandey, Edwin Cook, Jeremy Veenstra-VanderWeele

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2019

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Abstract

Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.
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Metagegevens
Titel
Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder
Auteurs
Elizabeth Aaron
Alicia Montgomery
Xinguo Ren
Stephen Guter
George Anderson
Ana M. D. Carneiro
Suma Jacob
Matthew Mosconi
Ghanshyam N. Pandey
Edwin Cook
Jeremy Veenstra-VanderWeele
Publicatiedatum
29-03-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-03989-z