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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2018

12-10-2017 | Original Paper

White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism

Auteurs: Odette Fründt, Robert Schulz, Daniel Schöttle, Bastian Cheng, Götz Thomalla, Hanna Braaß, Christos Ganos, Nicole David, Ina Peiker, Andreas K. Engel, Tobias Bäumer, Alexander Münchau

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2018

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Abstract

Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating “emulation”) and the alternative temporo-frontal route (mediating “mimicry”). Multiple linear regression was used to investigate structure–function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.

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Metagegevens
Titel
White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism
Auteurs
Odette Fründt
Robert Schulz
Daniel Schöttle
Bastian Cheng
Götz Thomalla
Hanna Braaß
Christos Ganos
Nicole David
Ina Peiker
Andreas K. Engel
Tobias Bäumer
Alexander Münchau
Publicatiedatum
12-10-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3332-9