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01-08-2013

What is the use? Application of the short form (SF) questionnaires for the evaluation of treatment effects

Auteurs: Aline J. Pelle, Nina Kupper, Floortje Mols, Peter de Jonge

Gepubliceerd in: Quality of Life Research | Uitgave 6/2013

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Abstract

Background

Health status has evolved as a clinical outcome measure that is of great interest in medical care. However, there is still debate about the appropriateness of scoring algorithms for the often used short form questionnaires. Therefore, our aim was to evaluate the consequences of the traditional scoring procedure based on orthogonal factor rotation for clinical applications by (a) re-evaluating the results of randomized controlled trials (RCTs) on the effectiveness of antidepressants in improving health status in cardiac patients and (b) comparing empirical evidence on depression and health status using orthogonal and oblique factor rotation (alternative scoring method) in a community sample and a heart failure (HF) sample.

Methods

This is a systematic literature review and cross-sectional analysis among 1,598 community sample participants and 282 HF patients.

Results

Orthogonal rotation artificially forces the mental component summary (MCS) and physical component summary (PCS) to be unrelated, which is illustrated in two of the three included RCTs. Two RCTs showed improvements in MCS, but no improvement in PCS over time. Cross-sectional analysis in the two datasets showed that employing the alternative scoring algorithm resulted in higher negative correlations of MCS and PCS with depression, and a gradual decline in MCS with each decile of decline in PCS.

Conclusion

Our data showed that appropriate carefulness is needed when calculating and interpreting summary scores. The traditional scoring algorithm seems inappropriate to objectively evaluate the effects of interventions on both the MCS and the PCS. Awareness in the design and evaluation of interventions using these outcomes is warranted.
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Metagegevens
Titel
What is the use? Application of the short form (SF) questionnaires for the evaluation of treatment effects
Auteurs
Aline J. Pelle
Nina Kupper
Floortje Mols
Peter de Jonge
Publicatiedatum
01-08-2013
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-012-0266-8