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The online version of this article (doi:10.1007/s10802-013-9796-y) contains supplementary material, which is available to authorized users.
Autism shows a high degree of comorbidity with anxiety disorders. Adolescence is a time of increased stress and vulnerability to internalising problems. This study addresses for the first time the degree of genetic and environmental overlap between autistic traits (total measure and subscales) and internalising traits in a community-based adolescent twin sample. Parents of 12-14-year-old twins (N = 3,232 pairs; 3,460 males, 3,004 females) reported on the twins’ internalising and autistic traits. Autistic trait subscales were created using principal component analysis. Bivariate twin model-fitting was conducted. Autistic and internalising traits correlated moderately (r = 0.30). Genetic influences on individual traits were substantial but genetic overlap between traits was moderate (genetic correlation: males = 0.30, females = 0.12). Shared environmental influences were low for internalising traits and moderate for autistic traits, and showed considerable overlap (shared environmental correlation: males = 0.53, females = 1). Nonshared environmental influences were moderate for internalising traits and low for autistic traits and showed low overlap. A multiple component solution was found for autistic traits and of the derived subscales, autistic-like ‘Social Unease’ showed the most phenotypic and genetic overlap with internalising traits.
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Achenbach, T. M. (1991). Manual for the child behaviour checklist 1991 profile. Burlington: University of Vermont, Department of Psychiatry.
American Psychiatric Association APA (2000). Diagnostic and statistical manual of mental disorders (Fourth Edition: DSM-IV-TR ed.): American Psychiatric Pub.
Angold, A., Costello, E. J., Messer, S. C., Pickles, A., Winder, F., & Silver, D. (1995). Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents. International Journal of Methods in Psychiatric Research, 5, 237–249.
Gregory, A. M., & Eley, T. C. (2011). The genetic basis of child and adolescent anxiety. Anxiety disorders in children and adolescents (2nd ed.). Cambridge: Cambridge University Press.
Hoekstra, R. A., Vinkhuyzen, A. A. E., Wheelwright, S., Bartels, M., Boomsma, D. I., Baron-Cohen, S., et al. (2011). The construction and validation of an abridged version of the autism-spectrum quotient (AQ-Short). Journal of Autism and Developmental Disorders, 41, 589–596. PubMedCentralCrossRefPubMed
Hurst, R. M., Mitchell, J. T., Kimbrel, N. A., Kwapil, T. K., & Nelson-Gray, R. O. (2007). Examination of the reliability and factor structure of the autism spectrum quotient (AQ) in a non-clinical sample. Personality and Individual Differences, 43, 1938–1949. CrossRef
Ketelaars, C., Horwitz, E., Sytema, S., Bos, J., Wiersma, D., Minderaa, R., et al. (2008). Brief report: adults with mild autism spectrum disorders (asd): scores on the autism spectrum quotient (AQ) and comorbid psychopathology. Journal of Autism and Developmental Disorders, 38, 176–180. PubMedCentralCrossRefPubMed
Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 147, 424–433. CrossRef
Moffitt, T. E., Harrington, H., Caspi, A., Kim-Cohen, J., Goldberg, D., Gregory, A. M., et al. (2007). Depression and generalized anxiety disorder - cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. Archives of General Psychiatry, 64, 651–660. CrossRefPubMed
Neale, M. C. (1997). Mx: Statistical modeling (4th ed.). Charlottesville: Department of Psychiatry, Medical College of Virginia.
Price, T. S., Freeman, B., Craig, I., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129–133
Robinson, E. B., Koenen, K. C., McCormick, M. C., Munir, K., Hallett, V., Happé, F. et al. (2011a). Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5%, and 1%). Archives of General Psychiatry, 68, 1113–1121.
Robinson, E. B., Munir, K., Munafo, M. R., Hughes, M., McCormick, M. C., & Koenen, K. C. (2011b). Stability of autistic traits in the general population: further evidence for a continuum of impairment. Journal of the American Academy of Child and Adolescent Psychiatry, 50, 376–384. PubMedCentralCrossRefPubMed
Ronald, A., & Hoekstra, R. A. (2011). Autism spectrum disorders and autistic traits: a decade of new twin studies. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 156, 255–274. CrossRef
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 921–929. CrossRefPubMed
Wakabayashi, A., Baron-Cohen, S., & Wheelwright, S. (2006). Are autistic traits an independent personality dimension? A study of the autism-spectrum quotient (AQ) and the NEO-PI-R. Personality and Individual Differences, 41, 873–883. CrossRef
World Health Organisation WHO. (1992). ICD-10 classifications of mental and behavioural disorder: Clinical descriptions and diagnostic guidelines. Geneva: World Health Organisation.
Wood, J. J., & Gadow, K. D. (2010). Exploring the nature and function of anxiety in youth with autism spectrum disorders. Clinical Psychology-Science and Practice, 17, 281–292. CrossRef
- What Causes Internalising Traits and Autistic Traits to Co-occur in Adolescence? A Community-Based Twin Study
Thalia C. Eley
- Springer US