Swipe om te navigeren naar een ander artikel
To assess how vitamin D status is associated with health-related quality of life (HRQOL) among older residents of Canada.
We analysed baseline data of 1,493 Canadians aged 50 years and over in Alberta on HRQOL (EQ-5D-5L) and serum 25-hydroxyvitamin D (25(OH)D) as a measure of vitamin D status. We applied multivariable regression methods to examine the association between vitamin D status and each of the five dimensions and the summary index of the EQ-5D-5L.
Participants with higher serum 25(OH)D levels were significantly less likely to report problems with mobility, usual activities, and depression and anxiety. Specifically, age- and gender-adjusted odds ratios for reporting problems with mobility, usual activities, and depression and anxiety were 0.58 (95 % confidence interval 0.44–0.78), 0.67 (0.50–0.89), and 0.67 (0.51–0.88) per 100 nmol/L increase in 25(OH)D, respectively. No significant associations were observed for problems with self-care and with pain and discomfort. HRQOL scores combining the responses of each of the five dimensions increased significantly with increasing serum 25(OH)D levels.
This is the first study to reveal the importance of vitamin D for the five dimensions of HRQOL in a community-based sample. The observed associations of vitamin D and HRQOL call for intervention studies to strengthen the evidence of the potential benefits of vitamin D supplementation for HRQOL among older adults.
Committee to Review Dietary Reference Intakes for Vitamin D and Calcium Institute of Medicine, (2011). Dietary reference intakes for calcium and vitamin D. Washington, D.C.: The National Academies Press.
Health Canada (2012) Vitamin D and calcium: Updated dietary reference intakes. Health Canada. http://www.hc-sc.gc.ca/fn-an/nutrition/vitamin/vita-d-eng.php. Accessed October 20, 2013.
Langlois, K., Greene-Finestone, L., Little, J., Hidiroglou, N., & Whiting, S. (2010). Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Report, 21(1), 47–55.
Sohl, E., van Schoor, N. M., de Jongh, R. T., Visser, M., Deeg, D. J., & Lips, P. (2013). Vitamin D status is associated with functional limitations and functional decline in older individuals. The Journal of Clinical Endocrinology and Metabolism, 98(9), E1483–E1490. doi: 10.1210/jc.2013-1698. PubMedCrossRef
Murad, M. H., Elamin, K. B., Abu Elnour, N. O., Elamin, M. B., Alkatib, A. A., Fatourechi, M. M., et al. (2011). Clinical review: The effect of vitamin D on falls: A systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 96(10), 2997–3006. doi: 10.1210/jc.2011-1193. PubMedCrossRef
Bischoff-Ferrari, H. A., Dawson-Hughes, B., Staehelin, H. B., Orav, J. E., Stuck, A. E., Theiler, R., et al. (2009). Fall prevention with supplemental and active forms of vitamin D: A meta-analysis of randomised controlled trials. BMJ, 339, b3692. doi: 10.1136/bmj.b3692. PubMedCrossRefPubMedCentral
Janssen, H. C., Samson, M. M., & Verhaar, H. J. (2002). Vitamin D deficiency, muscle function, and falls in elderly people. The American Journal of Clinical Nutrition, 75(4), 611–615. PubMed
Heaney, R. P., French, C. B., Nguyen, S., Ferreira, M., Baggerly, L. L., Brunel, L., et al. (2013). A novel approach localizes the association of vitamin D status with insulin resistance to one region of the 25-hydroxyvitamin D continuum. Advance Nutrition, 4(3), 303–310. doi: 10.3945/an.113.003731. CrossRef
Oemar M, Janssen B (2013) EQ-5D-5L User guide basic information on how to use the EQ-5D-5L instrument. http://www.euroqol.org/fileadmin/user_upload/Documenten/PDF/Folders_Flyers/UserGuide_EQ-5D-5L_v2.0_October_2013.pdf. Accessed March 15, 2014.
Harris M (2013) Digital divide persists in Canada, both in access and Internet fluency. Financial Post, March 21, 2013, p Tech Desk.
World Health Organization (2013) Obesity and overweight. World Health Organization. http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed October 1, 2013.
Vieth, R., Bischoff-Ferrari, H., Boucher, B. J., Dawson-Hughes, B., Garland, C. F., Heaney, R. P., et al. (2007). The urgent need to recommend an intake of vitamin D that is effective. The American Journal of Clinical Nutrition, 85(3), 649–650. PubMed
Health Quality Council of Alberta (2013). Alberta Provincial Norms for EQ-5D-3L. http://www.hqca.ca/assets/files/Alberta%20Provincial%20Norms%20for%20EQ-5D%203L(1).pdf. Accessed March 15, 2014.
Bischoff-Ferrari, H. A., Giovannucci, E., Willett, W. C., Dietrich, T., & Dawson-Hughes, B. (2006). Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. The American Journal of Clinical Nutrition, 84(1), 18–28. PubMed
Ceglia, L. (2011). Simpson RU (2011) Vitamin D and skeletal muscle function. In D. Feldman, J. W. Pike, & J. S. Adams (Eds.), Vitamin D. Amsterdam, The Netherlands: Elsevier Science.
- Vitamin D and health-related quality of life in a community sample of older Canadians
Y. S. Chao
J. P. Ekwaru
P. J. Veugelers
- Springer International Publishing