Skip to main content
Top
Gepubliceerd in:

18-09-2019 | Original Paper

Variant Profile of MECP2 Gene in Sri Lankan Patients with Rett Syndrome

Auteurs: D. Hettiarachchi, N. F. Neththikumara, B. A. P. S. Pathirana, V. H. W. Dissanayake

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2020

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Rett syndrome (RTT) is a rare monogenic disorder affecting 1 in 10,000 live female births causing severe neurodegenerative symptoms. We analyzed the molecular genetic variants in the gene encoding the methyl-CpG binding protein 2 (MECP2) of 16 girls with RTT. Their mutation profile was as follows; Already described variants: p.R168X in 25% (n = 4), p.T158M in 25% (n = 4), p.R255X in 12.5% (n = 2), p.R133C in 12.5% (n = 2), p.R294X in 6.25% (n = 1), p.K177X in 6.25% (n = 1). Novel variants: a large deletion (c.868_1188del321) in 6.25% (n = 1) and a p.X499L in 6.25% (n = 1). We also looked at the genotype to phenotype correlation of these variants. Most of the mutations were C>T in CpG hot spot as seen in other populations.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Adzhubei, I., Schmidt, S., Peshkin, L., Ramensky, V., Gerasimova, A., Bork, P., et al. (2010). A method and server for predicting damaging missense mutations. Nature Methods,7(4), 248–249.PubMedPubMedCentral Adzhubei, I., Schmidt, S., Peshkin, L., Ramensky, V., Gerasimova, A., Bork, P., et al. (2010). A method and server for predicting damaging missense mutations. Nature Methods,7(4), 248–249.PubMedPubMedCentral
go back to reference Amir, R., Van den Veyver, I., Wan, M., Tran, C., Francke, U., & Zoghbi, H. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genetics,23(2), 185–188.PubMed Amir, R., Van den Veyver, I., Wan, M., Tran, C., Francke, U., & Zoghbi, H. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genetics,23(2), 185–188.PubMed
go back to reference Archer, H. (2006). CDKL5 mutations cause infantile spasms, early-onset seizures, and severe mental retardation in female patients. Journal of Medical Genetics,43(9), 729–734.PubMedPubMedCentral Archer, H. (2006). CDKL5 mutations cause infantile spasms, early-onset seizures, and severe mental retardation in female patients. Journal of Medical Genetics,43(9), 729–734.PubMedPubMedCentral
go back to reference Ariani, F., Hayek, G., Rondinella, D., Artuso, R., Mencarelli, M., Spanhol-Rosseto, A., et al. (2008). FOXG1 is responsible for the congenital variant of Rett syndrome. The American Journal of Human Genetics,83(1), 89–93.PubMed Ariani, F., Hayek, G., Rondinella, D., Artuso, R., Mencarelli, M., Spanhol-Rosseto, A., et al. (2008). FOXG1 is responsible for the congenital variant of Rett syndrome. The American Journal of Human Genetics,83(1), 89–93.PubMed
go back to reference Baker, S., Chen, L., Wilkins, A., Yu, P., Lichtarge, O., & Zoghbi, H. (2013). An AT-Hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. Cell,152(5), 984–996.PubMedPubMedCentral Baker, S., Chen, L., Wilkins, A., Yu, P., Lichtarge, O., & Zoghbi, H. (2013). An AT-Hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. Cell,152(5), 984–996.PubMedPubMedCentral
go back to reference Bebbington, A., Anderson, A., Ravine, D., Fyfe, S., Pineda, M., de Klerk, N., et al. (2008). Investigating genotype-phenotype relationships in Rett syndrome using an international data set. Neurology,70(11), 868–875.PubMed Bebbington, A., Anderson, A., Ravine, D., Fyfe, S., Pineda, M., de Klerk, N., et al. (2008). Investigating genotype-phenotype relationships in Rett syndrome using an international data set. Neurology,70(11), 868–875.PubMed
go back to reference Beyer, K., Blasi, F., Bacchelli, E., Klauck, S., Maestrini, E., Poustka, A., et al. (2002). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Human Genetics,111(4–5), 305–309.PubMed Beyer, K., Blasi, F., Bacchelli, E., Klauck, S., Maestrini, E., Poustka, A., et al. (2002). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Human Genetics,111(4–5), 305–309.PubMed
go back to reference Buschdorf, J., & Stratling, W. (2004). A WW domain binding region in methyl-CpG-binding protein MeCP2: Impact on Rett syndrome. Journal of Molecular Medicine,82(2), 135–143.PubMed Buschdorf, J., & Stratling, W. (2004). A WW domain binding region in methyl-CpG-binding protein MeCP2: Impact on Rett syndrome. Journal of Molecular Medicine,82(2), 135–143.PubMed
go back to reference Calfa, G., Percy, A., & Pozzo-Miller, L. (2011). Experimental models of Rett syndrome based on Mecp2 dysfunction. Experimental Biology and Medicine,236(1), 3–19.PubMed Calfa, G., Percy, A., & Pozzo-Miller, L. (2011). Experimental models of Rett syndrome based on Mecp2 dysfunction. Experimental Biology and Medicine,236(1), 3–19.PubMed
go back to reference Chahrour, M., Jung, S., Shaw, C., Zhou, X., Wong, S., Qin, J., et al. (2008). MeCP2, a key contributor to neurological disease, activates and represses transcription. Science,320(5880), 1224–1229.PubMedPubMedCentral Chahrour, M., Jung, S., Shaw, C., Zhou, X., Wong, S., Qin, J., et al. (2008). MeCP2, a key contributor to neurological disease, activates and represses transcription. Science,320(5880), 1224–1229.PubMedPubMedCentral
go back to reference Chandler, S., Guschin, D., Landsberger, N., & Wolffe, A. (1999). The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA. Biochemistry,38(22), 7008–7018.PubMed Chandler, S., Guschin, D., Landsberger, N., & Wolffe, A. (1999). The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA. Biochemistry,38(22), 7008–7018.PubMed
go back to reference Charman, T., Neilson, T., Mash, V., Archer, H., Gardiner, M., Knudsen, G., et al. (2005). Dimensional phenotypic analysis and functional categorization of mutations reveal novel genotype-phenotype associations in Rett syndrome. European Journal of Human Genetics,13(10), 1121–1130.PubMed Charman, T., Neilson, T., Mash, V., Archer, H., Gardiner, M., Knudsen, G., et al. (2005). Dimensional phenotypic analysis and functional categorization of mutations reveal novel genotype-phenotype associations in Rett syndrome. European Journal of Human Genetics,13(10), 1121–1130.PubMed
go back to reference Cheadle, J. (2000). Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: Correlation of disease severity with mutation type and location. Human Molecular Genetics,9(7), 1119–1129.PubMed Cheadle, J. (2000). Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: Correlation of disease severity with mutation type and location. Human Molecular Genetics,9(7), 1119–1129.PubMed
go back to reference Cuddapah, V., Pillai, R., Shekar, K., Lane, J., Motil, K., Skinner, S., et al. (2014). Methyl-CpG-binding protein 2(MECP2) mutation type is associated with disease severity in Rett syndrome. Journal of Medical Genetics,51(3), 152–158.PubMedPubMedCentral Cuddapah, V., Pillai, R., Shekar, K., Lane, J., Motil, K., Skinner, S., et al. (2014). Methyl-CpG-binding protein 2(MECP2) mutation type is associated with disease severity in Rett syndrome. Journal of Medical Genetics,51(3), 152–158.PubMedPubMedCentral
go back to reference D’Esposito, M., Quaderi, N., Ciccodicola, A., Bruni, P., Esposito, T., D’Urso, M., et al. (1996). Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2. Mammalian Genome,7(7), 533–535.PubMed D’Esposito, M., Quaderi, N., Ciccodicola, A., Bruni, P., Esposito, T., D’Urso, M., et al. (1996). Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2. Mammalian Genome,7(7), 533–535.PubMed
go back to reference Girard, M., Couvert, P., Carrié, A., Tardieu, M., Chelly, J., Beldjord, C., et al. (2001). Parental origin of de novo MECP2 mutations in Rett syndrome. European Journal of Human Genetics,9(3), 231.PubMed Girard, M., Couvert, P., Carrié, A., Tardieu, M., Chelly, J., Beldjord, C., et al. (2001). Parental origin of de novo MECP2 mutations in Rett syndrome. European Journal of Human Genetics,9(3), 231.PubMed
go back to reference Glaze, D. G., Percy, A. K., Skinner, S., Motil, K. J., Neul, J. L., Barrish, J. O., et al. (2010). Epilepsy and the natural history of Rett syndrome. Neurology,74(11), 909–912.PubMedPubMedCentral Glaze, D. G., Percy, A. K., Skinner, S., Motil, K. J., Neul, J. L., Barrish, J. O., et al. (2010). Epilepsy and the natural history of Rett syndrome. Neurology,74(11), 909–912.PubMedPubMedCentral
go back to reference Guy, J., Alexander-Howden, B., FitzPatrick, L., DeSousa, D., Koerner, M. V., Selfridge, J., et al. (2018). A mutation-led search for novel functional domains in MeCP2. Human Molecular Genetics,27(14), 2531–2545.PubMedPubMedCentral Guy, J., Alexander-Howden, B., FitzPatrick, L., DeSousa, D., Koerner, M. V., Selfridge, J., et al. (2018). A mutation-led search for novel functional domains in MeCP2. Human Molecular Genetics,27(14), 2531–2545.PubMedPubMedCentral
go back to reference Hagberg, B., Aicardi, J., Dias, K., & Ramos, O. (1983). A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett’s syndrome: Report of 35 cases. Annals of Neurology,14(4), 471–479.PubMed Hagberg, B., Aicardi, J., Dias, K., & Ramos, O. (1983). A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett’s syndrome: Report of 35 cases. Annals of Neurology,14(4), 471–479.PubMed
go back to reference Hoffbuhr, K., Devaney, J. M., LaFleur, B., Sirianni, N., Scacheri, C., Giron, J., et al. (2001). MeCP2 mutations in children with and without the phenotype of Rett syndrome. Neurology,56(11), 1486–1495.PubMed Hoffbuhr, K., Devaney, J. M., LaFleur, B., Sirianni, N., Scacheri, C., Giron, J., et al. (2001). MeCP2 mutations in children with and without the phenotype of Rett syndrome. Neurology,56(11), 1486–1495.PubMed
go back to reference Horvath, P. M., & Monteggia, L. M. (2018). MeCP2 is an activator of gene expression. Trends in Neurosciences,41(2), 72–74.PubMedPubMedCentral Horvath, P. M., & Monteggia, L. M. (2018). MeCP2 is an activator of gene expression. Trends in Neurosciences,41(2), 72–74.PubMedPubMedCentral
go back to reference Ip, J. P., Mellios, N., & Sur, M. (2018). Rett syndrome: Insights into genetic, molecular and circuit mechanisms. Nature Reviews Neuroscience,19(6), 368.PubMedPubMedCentral Ip, J. P., Mellios, N., & Sur, M. (2018). Rett syndrome: Insights into genetic, molecular and circuit mechanisms. Nature Reviews Neuroscience,19(6), 368.PubMedPubMedCentral
go back to reference Jian, L., Nagarajan, L., de Klerk, N., Ravine, D., Christodoulou, J., & Leonard, H. (2007). Seizures in Rett syndrome: An overview from a one-year calendar study. European Journal of Paediatric Neurology,11(5), 310–317.PubMedPubMedCentral Jian, L., Nagarajan, L., de Klerk, N., Ravine, D., Christodoulou, J., & Leonard, H. (2007). Seizures in Rett syndrome: An overview from a one-year calendar study. European Journal of Paediatric Neurology,11(5), 310–317.PubMedPubMedCentral
go back to reference Lallar, M., Rai, A., Srivastava, P., Mandal, K., Gupta, N., Kabra, M., et al. (2018). Molecular testing of MECP2 gene in Rett syndrome phenotypes in Indian girls. Indian Pediatrics,55(6), 474–477.PubMed Lallar, M., Rai, A., Srivastava, P., Mandal, K., Gupta, N., Kabra, M., et al. (2018). Molecular testing of MECP2 gene in Rett syndrome phenotypes in Indian girls. Indian Pediatrics,55(6), 474–477.PubMed
go back to reference Larvick, C. L., de Klerk, N., Bower, C., Christodoulou, J., Ravine, D., Ellaway, C., et al. (2006). Rett syndrome in Australia: A review of the epidemiology. The Journal of pediatrics,148(3), 347–352. Larvick, C. L., de Klerk, N., Bower, C., Christodoulou, J., Ravine, D., Ellaway, C., et al. (2006). Rett syndrome in Australia: A review of the epidemiology. The Journal of pediatrics,148(3), 347–352.
go back to reference Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., et al. (1992). Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell,69(6), 905–914.PubMed Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., et al. (1992). Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell,69(6), 905–914.PubMed
go back to reference Li, M. R., Pan, H., Bao, X. H., Zhang, Y. Z., & Wu, X. R. (2007). MECP2 and CDKL5 gene mutation analysis in Chinese patients with Rett syndrome. Journal of Human Genetics,52(1), 38.PubMed Li, M. R., Pan, H., Bao, X. H., Zhang, Y. Z., & Wu, X. R. (2007). MECP2 and CDKL5 gene mutation analysis in Chinese patients with Rett syndrome. Journal of Human Genetics,52(1), 38.PubMed
go back to reference Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T. R., et al. (2018). Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. Journal of Biological Chemistry,293(19), 7344–7354.PubMed Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T. R., et al. (2018). Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. Journal of Biological Chemistry,293(19), 7344–7354.PubMed
go back to reference Lopes, F., Barbosa, M., Ameur, A., Soares, G., de Sá, J., Dias, A. I., et al. (2016). Identification of novel genetic causes of Rett syndrome-like phenotypes. Journal of Medical Genetics, 53(3), 190–199.PubMed Lopes, F., Barbosa, M., Ameur, A., Soares, G., de Sá, J., Dias, A. I., et al. (2016). Identification of novel genetic causes of Rett syndrome-like phenotypes. Journal of Medical Genetics, 53(3), 190–199.PubMed
go back to reference Müller, M. (2019). Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome. Neuroscience & Biobehavioral Reviews. Müller, M. (2019). Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome. Neuroscience & Biobehavioral Reviews.
go back to reference Neul, J. L., Fang, P., Barrish, J., Lane, J., Caeg, E. B., Smith, E. O., et al. (2008). Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome. Neurology,70(16), 1313–1321.PubMedPubMedCentral Neul, J. L., Fang, P., Barrish, J., Lane, J., Caeg, E. B., Smith, E. O., et al. (2008). Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome. Neurology,70(16), 1313–1321.PubMedPubMedCentral
go back to reference Neul, J. L., Kaufmann, W. E., Glaze, D. G., Christodoulou, J., Clarke, A. J., Bahi‐Buisson, N., … & Renieri, A. (2010). Rett syndrome: Revised diagnostic criteria and nomenclature. Annals of neurology, 68(6), pp. 944–950 Neul, J. L., Kaufmann, W. E., Glaze, D. G., Christodoulou, J., Clarke, A. J., Bahi‐Buisson, N., … & Renieri, A. (2010). Rett syndrome: Revised diagnostic criteria and nomenclature. Annals of neurology, 68(6), pp. 944–950
go back to reference Percy, A. K. (2008). Rett syndrome: Recent research progress. Journal of child neurology,23(5), 543–549.PubMed Percy, A. K. (2008). Rett syndrome: Recent research progress. Journal of child neurology,23(5), 543–549.PubMed
go back to reference Percy, A. K., Lane, J. B., Childers, J., Skinner, S., Annese, F., Barrish, J., et al. (2007). Rett syndrome: North American database. Journal of Child Neurology,22(12), 1338–1341.PubMed Percy, A. K., Lane, J. B., Childers, J., Skinner, S., Annese, F., Barrish, J., et al. (2007). Rett syndrome: North American database. Journal of Child Neurology,22(12), 1338–1341.PubMed
go back to reference Psoni, S., Sofocleous, C., Traeger-Synodinos, J., Kitsiou-Tzeli, S., Kanavakis, E., & Fryssira-Kanioura, H. (2012). MECP2 mutations and clinical correlations in Greek children with Rett syndrome and associated neurodevelopmental disorders. Brain and Development,34(6), 487–495.PubMed Psoni, S., Sofocleous, C., Traeger-Synodinos, J., Kitsiou-Tzeli, S., Kanavakis, E., & Fryssira-Kanioura, H. (2012). MECP2 mutations and clinical correlations in Greek children with Rett syndrome and associated neurodevelopmental disorders. Brain and Development,34(6), 487–495.PubMed
go back to reference Rai, V. (2011). Autism genetics: Recent advances in candidate gene search. International J Genetic Engineering and Biotechnology,2(1), 47–66. Rai, V. (2011). Autism genetics: Recent advances in candidate gene search. International J Genetic Engineering and Biotechnology,2(1), 47–66.
go back to reference Schanen, C., Houwink, E. J., Dorrani, N., Lane, J., Everett, R., Feng, A., et al. (2004). Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. American Journal of Medical Genetics Part A,126(2), 129–140. Schanen, C., Houwink, E. J., Dorrani, N., Lane, J., Everett, R., Feng, A., et al. (2004). Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. American Journal of Medical Genetics Part A,126(2), 129–140.
go back to reference Schwarz, J. M., Cooper, D. N., Schuelke, M., & Seelow, D. (2014). Mutation Taster2: Mutation prediction for the deep-sequencing age. Nature Methods,11(4), 361.PubMed Schwarz, J. M., Cooper, D. N., Schuelke, M., & Seelow, D. (2014). Mutation Taster2: Mutation prediction for the deep-sequencing age. Nature Methods,11(4), 361.PubMed
go back to reference Steffenburg, U., Hagberg, G., & Hagberg, B. (2001). Epilepsy in a representative series of Rett syndrome. Acta Paediatrica,90(1), 34–39.PubMed Steffenburg, U., Hagberg, G., & Hagberg, B. (2001). Epilepsy in a representative series of Rett syndrome. Acta Paediatrica,90(1), 34–39.PubMed
go back to reference Suter, B., Treadwell-Dearing, D., Zoghbi, H., Glaze, D., & Neul, J. L. (2010). MECP2 mutations in people without Rett syndrome. Annals of Neurology,68(4), S98–S99. Suter, B., Treadwell-Dearing, D., Zoghbi, H., Glaze, D., & Neul, J. L. (2010). MECP2 mutations in people without Rett syndrome. Annals of Neurology,68(4), S98–S99.
go back to reference Townend, G. S., Ehrhart, F., van Kranen, H. J., Wilkinson, M., Jacobsen, A., Roos, M., et al. (2018). MECP2 variation in Rett syndrome—An overview of current coverage of genetic and phenotype data within existing databases. Human Mutation,39(7), 914–924.PubMedPubMedCentral Townend, G. S., Ehrhart, F., van Kranen, H. J., Wilkinson, M., Jacobsen, A., Roos, M., et al. (2018). MECP2 variation in Rett syndrome—An overview of current coverage of genetic and phenotype data within existing databases. Human Mutation,39(7), 914–924.PubMedPubMedCentral
go back to reference Trappe, R., Laccone, F., Cobilanschi, J., Meins, M., Huppke, P., Hanefeld, F., et al. (2001). MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin. The American Journal of Human Genetics,68(5), 1093–1101.PubMed Trappe, R., Laccone, F., Cobilanschi, J., Meins, M., Huppke, P., Hanefeld, F., et al. (2001). MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin. The American Journal of Human Genetics,68(5), 1093–1101.PubMed
go back to reference Weaving, L. S., Ellaway, C. J., Gecz, J., & Christodoulou, J. (2005). Rett syndrome: Clinical review and genetic update. Journal of Medical Genetics,42(1), 1–7.PubMedPubMedCentral Weaving, L. S., Ellaway, C. J., Gecz, J., & Christodoulou, J. (2005). Rett syndrome: Clinical review and genetic update. Journal of Medical Genetics,42(1), 1–7.PubMedPubMedCentral
go back to reference Young, J. I., Hong, E. P., Castle, J. C., Crespo-Barreto, J., Bowman, A. B., Rose, M. F., et al. (2005). Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proceedings of the National Academy of Sciences,102(49), 17551–17558. Young, J. I., Hong, E. P., Castle, J. C., Crespo-Barreto, J., Bowman, A. B., Rose, M. F., et al. (2005). Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proceedings of the National Academy of Sciences,102(49), 17551–17558.
go back to reference Zhu, X., Li, M., Pan, H., Bao, X., Zhang, J., & Wu, X. (2010). Analysis of the parental origin of de novo MECP2 mutations and X chromosome inactivation in 24 sporadic patients with Rett syndrome in China. Journal of Child Neurology,25(7), 842–848.PubMed Zhu, X., Li, M., Pan, H., Bao, X., Zhang, J., & Wu, X. (2010). Analysis of the parental origin of de novo MECP2 mutations and X chromosome inactivation in 24 sporadic patients with Rett syndrome in China. Journal of Child Neurology,25(7), 842–848.PubMed
go back to reference Zoghbi, H. Y. (2003). Postnatal neurodevelopmental disorders: Meeting at the synapse? Science,302(5646), 826–830.PubMed Zoghbi, H. Y. (2003). Postnatal neurodevelopmental disorders: Meeting at the synapse? Science,302(5646), 826–830.PubMed
Metagegevens
Titel
Variant Profile of MECP2 Gene in Sri Lankan Patients with Rett Syndrome
Auteurs
D. Hettiarachchi
N. F. Neththikumara
B. A. P. S. Pathirana
V. H. W. Dissanayake
Publicatiedatum
18-09-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04230-7