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Quality of Life Research
Gepubliceerd in: Quality of Life Research 6/2007

01-08-2007

Validity, reliability and clinical relevance of EORTC QLQ-C30 and LC13 in patients with chest malignancies in a palliative setting

Auteurs: Mercedes Nicklasson, Bengt Bergman

Gepubliceerd in: Quality of Life Research | Uitgave 6/2007

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Abstract

Aims

To evaluate the reliability and validity of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and LC13 questionnaire in a palliative setting, and to undertake a broad clinical evaluation of the questionnaire.

Patients

One hundred and twelve patients with advanced lung cancer or pleural mesothelioma, not amenable to curative or life-prolonging treatment, were consecutively included.

Methods

Construct validity and reliability of the EORTC questionnaire were examined by multitrait analysis and internal consistency. Criterion validity was examined by variance by and correlation with an array of clinical measures, including tumour stage, performance status, 6-min walk test, spirometry, and blood tests. Concurrent validity was evaluated by established scales for emotional distress and pain.

Results

With the exception of cognitive functioning, reliability and construct validity of the QLQ-C30 was confirmed. Criterion and concurrent validity was supported for most of the functioning and symptom scales. In a multivariate stepwise regression analysis, EORTC physical functioning was predicted by performance status and 6-min walk distance (r 2 = .70), emotional functioning by HADS anxiety ratings (r 2 = .59), and global quality of life by performance status, HADS depression ratings, and FEV1 %predicted (r 2 = .50).

Conclusion

The results support the validity and clinical relevance and of the EORTC questionnaire in a palliative setting.
vorige artikel Responsiveness to change to change due to supportive-expressive group therapy, improvement in mood and disease progression in women with metastatic breast cancer
volgende artikel Measurement of overall quality of life in nursing homes through self-report: the role of cognitive impairment
Literatuur
1.
Morrow, G. R., Lindke, J., & Black, P. (1992). Measurement of quality of life in patients: psychometric analyses of the functional living index-cancer (FLIC). Quality of Life Research, 1, 287–296.PubMedCrossRef
2.
Cella, D. F., Tulsky, D. S., Gray, G., et al. (1993). The functional assessment of cancer therapy (FACT) scale: Development and validation of the general measure. Journal of Clinical Oncology, 11, 570–579.PubMed
3.
Hollen, P. J., Gralla, R. J., Kris, M. G., Cox, C., Belani, C. P., & Grunberg, S. M., et al. (1994). Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies. Psychometric assessment of the Lung Cancer Symptom Scale Cancer, 73, 2087–2098.PubMedCrossRef
4.
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N., et al. (1993). The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85, 365–376.PubMedCrossRef
5.
Bergman, B., Aaronson, N. K., Ahmedzai, S., Kaasa, S., & Sullivan, M. (1994). The EORTC QLQ-LC13: A modular supplement to the EORTC core quality of life questionnaire (QLQ-C30) for use in lung cancer clinical trials. European Journal of Cancer, 30, 635–642.CrossRef
6.
de Haes, J., Curran, D., Young, T., Bottomley, A., Flechtner, H., Aaronson, N., et al. (2000). Quality of life evaluation in oncological clinical trials–the EORTC model. The EORTC quality of life study group. European Journal of Cancer, 36, 821–825.PubMedCrossRef
7.
Osoba, D., Zee, B., Pater, J., Warr, D., Kaizer, L., & Latreille, J. (1994). Psychometric properties and responsiveness of the EORTC quality of life questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer. Quality of Life Research, 3, 353–364.PubMedCrossRef
8.
Osoba, D., Rodrigues, G., Myles, J., Zee, B., & Pater, J. (1998). Interpreting the significance of changes in health related quality of life scores. Journal of the Clinical Oncology, 16, 139–144.
9.
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67, 361–370.PubMedCrossRef
10.
Daut, R. L., Cleeland, C. S., & Flanery, R. C. (1983). Development of the Wisconsin brief pain questionnaire to assess pain in cancer and other diseases. Pain, 17, 197–210.PubMedCrossRef
11.
The EORTC QL Group website. www.eortc.be/home/qol.
12.
Sjösteen, A., Lundqvist, C., blomstrand, C., Sullivan, L., & Sullivan, M. (1990). The quality of life of three functional spinal cord injury subgroups in a swedish community. Paraplegia, 28, 476–488.
13.
Bergman, B., Sullivan, M., & Sörenson, S. (1991). Quality of life during chemotherapy for small cell lung cancer. I. An evaluation with generic health measures. Acta Oncologica, 30, 947–957.PubMedCrossRef
14.
Hammerlid, E., Ahlner-Elmqvist, M., Bjordal, K., Biorklund, A., Evensen, J., Boysen, M., et al. (1999). A prospective multicentre study in Sweden and Norway of mental distress and psychiatric morbidity in head and neck cancer patients. British Journal of Cancer, 80, 766–774.PubMedCrossRef
15.
Bernhard, J., Sullivan, M., Hurny, C., Coates, A. S., & Rudenstam, C. M. (2001). Clinical relevance of single item quality of life indicators in cancer clinical trials. British Journal of Cancer, 84, 1156–1165.PubMedCrossRef
16.
Bergenmar, M., Nilsson, B., Hansson, J., & Brandberg, Y. (2004). Anxiety and depressive symptoms measured by the hospital anxiety and depression scale as predictors of time to recurrence in localized cutaneous melanoma. Acta Oncologica, 43, 161–168.PubMedCrossRef
17.
Karnofsky, D. A., & Burchenal, J. H. (1949). The clinical evaluation of chemotherapeutic agents in cancer. In C. M. McLeod (Ed.), Evaluation of chemotherapeutic agents in cancer (pp. 191–205). New York: Columbia University Press.
18.
WHO. (1979). Handbook for reporting results of cancer treatment. Geneva: WHO.
19.
Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrica, 16, 297–334.CrossRef
20.
Cohen J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: Lawrence Erlbaum Associates.
21.
Fayers, P., Weeden, S., & Curran, D. (1998). On behalf of the EORTC quality of life study group. EORTC QLQ-C30 reference values. Brussels: EORTC.
22.
Osoba, D., Aaronson, N., Zee, B., Sprangers, M., & te Velde, A. (1997). Modification of the EORTC QLQ-C30 (version 2.0) based on content validity and reliability testing in large samples of patients with cancer. The study group on quality of life of the EORTC and the symptom control and quality of life committees of the NCI of Canada clinical trials group. Quality of Life Research, 6, 103–108.PubMedCrossRef
23.
Billingham, L. J., & Cullen, M. H. (2001). The benefits of chemotherapy in patient subgroups with unresectable non-small-cell lung cancer. Annals of Oncology, 12, 1671–1675.PubMedCrossRef
24.
Jones, P. W., & Bergman, B. (1990). Quality of life assessment in COPD. Poor correlation between spirometry and patient ratings. Lakartidningen, 87, 1372–1375.PubMed
25.
Groenvold, M., Petersen, M. A., Aaronson, N., Arraras, J. L., Blazeby, J. M., Bottomley, A., et al. (2006). The development of the EORTC QLQ-C15-PAL: A shortened questionnaire for cancer patients in palliative care. European Journal of Cancer, 42, 55–64.PubMedCrossRef
26.
Petersen, M. A., Groenvold, M., Aaronson, N., Blazeby, J., Brandberg, Y., de Graeff, A., et al. (2006). Item response theory was used to shorten EORTC QLQ-C30 scales for use in palliative care. Journal of Clinical Epidemiology, 59, 36–44.PubMedCrossRef
27.
Stromgren, A. S., Goldscmidt, D., Groenvold, M., Petersen, M. A., Jensen, P. T., Pedersen, L., et al. (2002). Self-assessment in cancer patients referred to palliative care: a study of feasibility and symptom epidemiology. Cancer, 94, 512–520.PubMedCrossRef
28.
Lund Hagelin, C., Seiger, A., & Furst, C. J. (2006). Quality of life in terminal care–with special reference to age, gender and marital status. Support Care Cancer, 14, 320–328.CrossRef
Metagegevens
Titel
Validity, reliability and clinical relevance of EORTC QLQ-C30 and LC13 in patients with chest malignancies in a palliative setting
Auteurs
Mercedes Nicklasson
Bengt Bergman
Publicatiedatum
01-08-2007
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2007
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-007-9210-8

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