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01-05-2014 | Uitgave 4/2014

Quality of Life Research 4/2014

Validation of a Quality of Life Questionnaire for Bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0

Quality of Life Research > Uitgave 4/2014
Casilda Olveira, Gabriel Olveira, Francisco Espildora, Rosa-Maria Giron, Gerard Muñoz, Alexandra L. Quittner, Miguel-Angel Martinez-Garcia
Belangrijke opmerkingen
This study is included in the PII of Bronchiectasis of SEPAR (Spanish Society of Pulmonology and Thoracic Surgery).
Montserrat Vendrell (Universitary Hospital Dr Josep Trueta, Gerona, Spain) and Nuria Porras (Endocrinology and Nutrition Service, Carlos Haya University Hospital, Malaga, Spain) also participated in this study.



Bronchiectasis is a chronic disease, leading to worsening of health-related quality of life. This study evaluated the psychometric properties of a new patient-reported outcome for non-cystic fibrosis bronchiectasis, the Quality of Life Questionnaire Bronchiectasis, translated into Spanish (QOL-B-Sp-V3.0).


This prospective study recruited clinically stable patients with non-cystic fibrosis bronchiectasis at 4 Spanish centers. Health status was assessed with multiple indicators (dyspnea, exacerbations, bronchorrhea, etc.), microbiological, radiological, spirometric, and anthropometric parameters plus St-George Respiratory Questionnaire (SGRQ). Psychometric analyses included internal consistency, test–retest reliability, convergent validity, predictive validity, and responsivity to change.


The 207 stable patients (mean age 57.2 years) had a Bhalla score of 11.53 ± 7.39 and FEV1% of 68.3 ± 22.2 %. One hundred and sixty-one stable patients repeated the test 2 weeks later, and 80 patients who had an exacerbation within 6 months of the assessment also repeated it. Internal consistency was high across all scales (Cronbach’s alpha >0.70). Thirty-six of 37 items correlated more strongly with their assigned scale than a competing scale. Test–retest coefficients were strong (intraclass correlations r = 0.68–0.88). All scales, except Treatment Burden, discriminated significantly between patients with mild, moderate, and severe disease according to FEV1% and other respiratory parameters. Strong convergence was found between the QOL-B-Sp-V3.0 and SGRQ. Significant correlations were found between QOL-B-Sp-V3.0 and various clinical, spirometric, radiological, and anthropometric variables. Significant differences were found on all QOL-B-Sp-V3.0 scales, except emotional functioning, between the baseline responses and onset of an exacerbation; robust sensitivity to change was observed on the Respiratory Symptoms scale.


The QOL-B-Sp-V3.0 questionnaire demonstrated strong reliability and validity. Scores were reproducible after 2 weeks, and it discriminated between patients who varied in severity and was responsive to changes related to exacerbation.

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