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Gepubliceerd in: Quality of Life Research 4/2014

01-05-2014

Validation and comparison of 15-D and EQ-5D-5L instruments in a Spanish Parkinson’s disease population sample

Auteurs: Miguel Ángel García-Gordillo, Borja del Pozo-Cruz, José Carmelo Adsuar, Fernando Ignacio Sánchez-Martínez, José María Abellán-Perpiñán

Gepubliceerd in: Quality of Life Research | Uitgave 4/2014

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Abstract

Purpose

To contribute to the ongoing discussion on the choice of a preference-based health-related quality of life (HRQoL) instrument to be used in cost-effectiveness analysis by studying and comparing the validity, sensitivity and relative efficiency of 15-D and EuroQol 5D 5L (EQ-5D-5L) in a Spanish Parkinson’s disease (PD) population sample.

Methods

One hundred and thirty-three volunteers were asked to complete an interview using 15-D and EQ-5D-5L. Spearman’s rank correlation coefficient (r) was used to test the convergent validity of these instruments with specific PD measures. Sensitivity and efficiency were compared using receiver operating characteristic (ROC) curves and relative efficiency statistic, respectively.

Results

A strong correlation (r > 0.65; p < 0.001) was found between both 15-D and EQ-5D-5L utilities with the summary score of the PDQ-8, and a strong correlation (r > 0.50; p < 0.001) was found between 15-D and EQ-5D-5L utilities with the EQ-VAS. The areas under the ROC of both instruments all exceeded 0.5 (p < 0.001). The 15-D instrument was 4.1–29.8 % less efficient at detecting differences between patients with optimal HRQoL, while this instrument was 11 % more efficient at detecting differences between patients at mild and moderate to strong severity of the PD symptoms.

Conclusions

15-D and EQ-5D-5L are showed to be valid and sensitivity generic HRQoL measures in Spanish PD patients with both instruments showing similar HRQoL dimension coverage and ceiling/floor effects. The 15-D has better efficiency and greater sensitivity to detect clinical changes in PD severity of the symptoms meanwhile the EQ-5D-5L is better to detect clinical HRQoL changes. Additionally, the EQ-5D-5L questionnaire requires less time than 15-D to be administered, and it might be more appropriate for studies conducted in Spain, since a country-specific “value set” is available for this instrument and not for the 15-D.

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Metagegevens
Titel
Validation and comparison of 15-D and EQ-5D-5L instruments in a Spanish Parkinson’s disease population sample
Auteurs
Miguel Ángel García-Gordillo
Borja del Pozo-Cruz
José Carmelo Adsuar
Fernando Ignacio Sánchez-Martínez
José María Abellán-Perpiñán
Publicatiedatum
01-05-2014
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 4/2014
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-013-0569-4