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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2006

01-11-2006 | Original Paper

Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism

Auteurs: Colin A. Baron, Stephenie Y. Liu, Chindo Hicks, Jeffrey P. Gregg

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2006

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Abstract

In order to provide an alternative approach for understanding the biology and genetics of autism, we performed statistical analysis of gene expression profiles of lymphoblastoid cell lines derived from children with autism and their families. The goal was to assess the feasibility of using this model in identifying autism-associated genes. Replicate microarray experiments demonstrated that expression data from the cell lines were consistent and highly reproducible. Further analyses identified differentially expressed genes between cell lines derived from children with autism and those derived from their normally developing siblings. These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism.
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Metagegevens
Titel
Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism
Auteurs
Colin A. Baron
Stephenie Y. Liu
Chindo Hicks
Jeffrey P. Gregg
Publicatiedatum
01-11-2006
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0134-x

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