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01-10-2012 | Uitgave 8/2012

Quality of Life Research 8/2012

Using three legacy measures to develop a health-related quality of life tool for young adult survivors of childhood cancer

Tijdschrift:
Quality of Life Research > Uitgave 8/2012
Auteurs:
I-Chan Huang, Gwendolyn P. Quinn, Pey-Shan Wen, Elizabeth A. Shenkman, Dennis A. Revicki, Kevin Krull, Zhushan Li, Patricia D. Shearer

Abstract

Background

Little attention has been paid to selecting and developing health-related quality of life (HRQOL) measurement tools for young adult survivors of childhood cancer (YASCC). The primary purpose of this study was to develop a HRQOL tool for YASCC based on three legacy instruments.

Methods

Data collected from 151 YASCC were analyzed. HRQOL was measured using the Medical Outcomes Study SF-36, Quality of Life in Adult Cancer Survivors, and Quality of Life-Cancer Survivor. We used the following stages to develop our HRQOL tool: mapping items from three instruments into a common HRQOL construct, checking dimensionality using confirmatory factor analyses (CFA), and equating items using Rasch modeling.

Results

We assigned 123 items to a HRQOL construct comprised of six generic and eight survivor-specific domains. CFA retained 107 items that meet the assumptions of unidimensionality and local independence. Rasch analysis retained 68 items that satisfied the indices of information-weighted/outlier-sensitive fit statistic mean square. However, items in most domains possess relatively easy measurement properties, whereas YASCC’s underlying HRQOL was on the middle to higher levels.

Conclusions

Psychometric properties of the established tool for measuring HRQOL of YASCC were not satisfied. Future studies need to refine this tool, especially adding more challenging items.

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