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Journal of Autism and Developmental Disorders

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01-12-2010 | Original Paper

Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions

Auteurs: Armando Bertone, Julie Hanck, Cary Kogan, Avi Chaudhuri, Kim Cornish

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2010

Abstract

The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue).

vorige artikel Validating the Repetitive Behavior Scale-Revised in Young Children with Autism Spectrum Disorder

volgende artikel Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling

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Titel: Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions
Auteurs: Armando Bertone
Julie Hanck
Cary Kogan
Avi Chaudhuri
Kim Cornish
Publicatiedatum: 01-12-2010
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 12/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-010-1109-5

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