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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-04-2014 | Letter to the Editor

Two Proposed Early Biomarker Tests of ASD: More Harm Than Good

Auteurs: George M. Anderson, Sherin S. Stahl

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2014

Excerpt

We have serious concerns regarding two recent highly publicized papers proposing early biomarker tests for autism or autism spectrum disorder (ASD) (Braunschweig et al. 2013, Walker et al. 2013). The paper of Braunschweig et al. concerns patterns of anti-brain antibodies detected in maternal plasma, while Walker et al. report on the occurrence of a microscopic morphological abnormality (the trophoblast inclusion) in placental tissue. Both groups suggest that their measure should be used clinically to test for autism/ASD risk and to influence early intervention, and websites promoting the tests have been established (pediatricbioscience.com; medicine.yale.edu/obgyn/kliman/autism/asd/index.aspx). …

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Anderson, G. M., Jacobs-Stannard, A., Chawarska, K., Volkmar, F. R., & Kliman, H. J. (2007). Placental trophoblast inclusions in autism spectrum disorder. Biological Psychiatry, 61(4), 487–491.PubMedCrossRef

Bauman, M. D., Iosif, A. M., Ashwood, P., Braunschweig, D., Lee, A., Schumann, C. M., et al. (2013). Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Translational Psychiatry, 3, e278.PubMedCentralPubMedCrossRef

Braunschweig, D., Krakowiak, P., Duncanson, P., Boyce, R., Hansen, R. L., Ashwood, P., et al. (2013). Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Translational Psychiatry, 3, e277.PubMedCentralPubMedCrossRef

Walker, C. K., Anderson, K. W., Milano, K. M., Ye, S., Tancredi, D. J., Pessah, I. N., et al. (2013). Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biological Psychiatry, 74(3), 204–211.PubMedCrossRef

Wingate, M., Mulvihill, B., Kirby, R. S., Pettygrove, S., Cunniff, C., Meaney, F., et al. (2012). Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders–Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveillance Summery, 61(3), 1–19.

Titel: Two Proposed Early Biomarker Tests of ASD: More Harm Than Good
Auteurs: George M. Anderson
Sherin S. Stahl
Publicatiedatum: 01-04-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1981-x

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