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Twists and turns: CRT-D with mixed Twiddler and Reel syndromes

  • Open Access
  • 18-12-2024
  • Heart Beat
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A 65-year-old woman with a cardiac resynchronisation therapy-defibrillator underwent routine device interrogation, revealing abnormalities in the atrial lead (reduced amplitude and occasional detection failure) and the right ventricular lead (increased pacing threshold) 13 months post-implantation. This prompted a chest X‑ray due to suspected lead dislodgement (Fig. 1b).
Fig. 1
a Chest radiography taken four months earlier for an unrelated purpose, already showing a rotated generator with some lead twisting. However, it was not reviewed by a cardiologist at that time. b Chest radiography at presentation, revealing both Twiddler and Reel syndromes, with leftward rotation of the pulse generator, CRT‑D lead twisting, and dislodged atrial and right ventricular leads. The left ventricular lead remained properly positioned. The intense twisting and progression between (a) and (b) suggest compulsive generator manipulation by the patient. c Movements involving the generator or leads contributing to various macro-dislodgement syndromes. Reproduced with permission from Elsevier [1] ©. Not covered by this article’s CC BY 4.0 License. Reuse requires Elsevier’s permission
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The X‑ray revealed twisted and macro-dislodged leads, along with pulse generator rotation, indicative of both Twiddler and Reel syndromes. These syndromes result from specific mechanisms of macro-dislodgement caused by movements of the generator or leads ([1]; Fig. 1c).
Potential risk factors are debated and include a psychiatric history, obesity, advanced age, an oversized pocket, manual manipulation, and the absence of generator fixation [2]. In our patient, the last two factors were present. Suturing the generator may be the most effective preventive strategy [3], although it is considered optional [4].
Even in the presence of risk factors, there are no specific guidelines recommending increased follow-up, reimplantation procedures, or routine radiography. However, routine imaging can be useful in identifying dislodgement [5] and is therefore advisable in conjunction with routine electrical testing. Lead revision is definitively recommended in cases of lead dysfunction [4].

Conflict of interest

P. Rossignon, R. Tajildin and E. Famdie declare that they have no competing interests.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Titel
Twists and turns: CRT-D with mixed Twiddler and Reel syndromes
Auteurs
Pierre Rossignon
Riad Tajildin
Edith Famdie
Publicatiedatum
18-12-2024
Uitgeverij
BSL Media & Learning
Gepubliceerd in
Netherlands Heart Journal / Uitgave 2/2025
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-024-01917-0
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go back to reference Nicholson WJ, Tuohy KA, Tilkemeier P. Twiddler’s syndrome. N Engl J Med. 2003;348:1726–7.CrossRefPubMed
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go back to reference Belvin D, Hirschl D, Jain VR, et al. Chest radiographs are valuable in demonstrating clinically significant pacemaker complications that require reoperation. Can Assoc Radiol J. 2011;62:288–95.CrossRefPubMed