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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2012

01-07-2012 | Letter

Twin Studies in Autism: What Might They Say About Genetic and Environmental Influences

Auteur: George M. Anderson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2012

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Abstract

Genetic and epigenetic differences exist within monozygote twin-pairs and might be especially important in the expression of autism. Assuming phenotypic differences between monozygotic twins are due to environmental influences may lead to mistaken conclusions regarding the relative genetic and environmental contribution to autism risk.
Literatuur
go back to reference Anderson, G. M. (2008). The potential role for emergence in autism. Autism Research, 1(1), 18–30.PubMedCrossRef Anderson, G. M. (2008). The potential role for emergence in autism. Autism Research, 1(1), 18–30.PubMedCrossRef
go back to reference Bell, J. T., & Spector, T. D. (2011). A twin approach to unraveling epigenetics. Trends in Genetics, 27(3), 116–125.PubMedCrossRef Bell, J. T., & Spector, T. D. (2011). A twin approach to unraveling epigenetics. Trends in Genetics, 27(3), 116–125.PubMedCrossRef
go back to reference Bruder, C. E., Piotrowski, A., Gijsbers, A. A., Andersson, R., Erickson, S., Diaz de Ståhl, T., et al. (2008). Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. American Journal of Human Genetics, 82(3), 763–771.PubMedCrossRef Bruder, C. E., Piotrowski, A., Gijsbers, A. A., Andersson, R., Erickson, S., Diaz de Ståhl, T., et al. (2008). Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. American Journal of Human Genetics, 82(3), 763–771.PubMedCrossRef
go back to reference Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095–1102.PubMedCrossRef Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with autism. Archives of General Psychiatry, 68(11), 1095–1102.PubMedCrossRef
go back to reference Haque F. N., Gottesman I. I., Wong A. H. (2009). Not really identical: Epigenetic differences in monozygotic twins and implications for twin studies in psychiatry. American Journal of Medical Genetic C Seminars in Medical Genetics, 15;151C(2):136–141. Haque F. N., Gottesman I. I., Wong A. H. (2009). Not really identical: Epigenetic differences in monozygotic twins and implications for twin studies in psychiatry. American Journal of Medical Genetic C Seminars in Medical Genetics, 15;151C(2):136–141.
go back to reference Lykken, D. T. (2006). The mechanism of emergenesis. Genes, Brain & Behavior, 5(4), 306–310.CrossRef Lykken, D. T. (2006). The mechanism of emergenesis. Genes, Brain & Behavior, 5(4), 306–310.CrossRef
go back to reference Sadler, T. W. (2006). Langman’s medical embryology (10th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. Sadler, T. W. (2006). Langman’s medical embryology (10th ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
go back to reference State, M. W., & Levitt, P. (2011). The conundrums of understanding genetic risks for autism spectrum disorders. Nature Neuroscience, 14(12), 1499–1506.PubMedCrossRef State, M. W., & Levitt, P. (2011). The conundrums of understanding genetic risks for autism spectrum disorders. Nature Neuroscience, 14(12), 1499–1506.PubMedCrossRef
go back to reference Steinmetz, H., Herzog, A., Schlaug, G., Huang, Y., & Jäncke, L. (1995). Brain (A) symmetry in monozygotic twins. Cerebral Cortex, 5(4), 296–300.PubMedCrossRef Steinmetz, H., Herzog, A., Schlaug, G., Huang, Y., & Jäncke, L. (1995). Brain (A) symmetry in monozygotic twins. Cerebral Cortex, 5(4), 296–300.PubMedCrossRef
go back to reference Stromswold, K. (2006). Why aren’t identical twins linguistically identical? Cognition, 101(2), 333–384.PubMedCrossRef Stromswold, K. (2006). Why aren’t identical twins linguistically identical? Cognition, 101(2), 333–384.PubMedCrossRef
go back to reference Szatmari, P. (2011). Is autism, at least in part, a disorder of fetal programming? Archives of General Psychiatry, 68(11), 1091–1092.PubMedCrossRef Szatmari, P. (2011). Is autism, at least in part, a disorder of fetal programming? Archives of General Psychiatry, 68(11), 1091–1092.PubMedCrossRef
go back to reference Titlestad, I. L., Kyvik, K. O., Kristensen, T., & Lillevang, S. (2002). HLA haplotypes in dizygotic twin pairs: are dizygotic twins more similar than sibs? Twin Research, 5(4), 287–288.PubMed Titlestad, I. L., Kyvik, K. O., Kristensen, T., & Lillevang, S. (2002). HLA haplotypes in dizygotic twin pairs: are dizygotic twins more similar than sibs? Twin Research, 5(4), 287–288.PubMed
go back to reference Zwijnenburg, P. J., Meijers-Heijboer, H., & Boomsma, D. I. (2010). Identical but not the same: the value of discordant monozygotic twins in genetic research. American Journal of Medical Genetics, B Neuropsychiatric Genetics, 153B(6), 1134–1149. Zwijnenburg, P. J., Meijers-Heijboer, H., & Boomsma, D. I. (2010). Identical but not the same: the value of discordant monozygotic twins in genetic research. American Journal of Medical Genetics, B Neuropsychiatric Genetics, 153B(6), 1134–1149.
Metagegevens
Titel
Twin Studies in Autism: What Might They Say About Genetic and Environmental Influences
Auteur
George M. Anderson
Publicatiedatum
01-07-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1552-6

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