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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2009

01-05-2009 | Original Paper

Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders

Auteurs: Lawrence Scahill, Michael G. Aman, Christopher J. McDougle, L. Eugene Arnold, James T. McCracken, Benjamin Handen, Cynthia Johnson, James Dziura, Eric Butter, Denis Sukhodolsky, Naomi Swiezy, James Mulick, Kimberly Stigler, Karen Bearss, Louise Ritz, Ann Wagner, Benedetto Vitiello

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2009

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Abstract

This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice.
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Metagegevens
Titel
Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Auteurs
Lawrence Scahill
Michael G. Aman
Christopher J. McDougle
L. Eugene Arnold
James T. McCracken
Benjamin Handen
Cynthia Johnson
James Dziura
Eric Butter
Denis Sukhodolsky
Naomi Swiezy
James Mulick
Kimberly Stigler
Karen Bearss
Louise Ritz
Ann Wagner
Benedetto Vitiello
Publicatiedatum
01-05-2009
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-008-0675-2

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