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01-09-2012 | Original article

Treatment of non-culprit lesions detected during primary PCI: long-term follow-up of a randomised clinical trial

Auteurs: A. Ghani, J-H. E. Dambrink, A. W. J. van ’t Hof, J. P. Ottervanger, A. T. M. Gosselink, J. C. A. Hoorntje

Gepubliceerd in: Netherlands Heart Journal | Uitgave 9/2012

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Abstract

Background

There are conflicting data regarding optimal treatment of non-culprit lesions detected during primary percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) and multi-vessel disease (MVD). We aimed to investigate whether ischaemia-driven early invasive treatment improves the long-term outcome and prevents major adverse cardiac events (MACE).

Methods

121 patients with at least one non-culprit lesion were randomised in a 2:1 manner, 80 were randomised to early fractional flow reserve (FFR)-guided PCI (invasive group), and 41 to medical treatment (conservative group). The primary endpoint was MACE at 3 years.

Results

Three-year follow-up was available in 119 patients (98.3 %). There was no significant difference in all-cause mortality between the invasive and conservative strategy, 4 patients (3.4 %) died, all in the invasive group (P = 0.29). Re-infarction occurred in 14 patients (11.8 %) in the invasive group versus none in the conservative group (p = 0.002). Re-PCI was performed in 7 patients (8.9 %) in the invasive group and in 13 patients (32.5 %) in the conservative group (P = 0.001). There was no difference in MACE between these two strategies (35.4 vs 35.0 %, p = 0.96).

Conclusions

In STEMI patients with MVD, early FFR-guided additional revascularisation of the non-culprit lesion did not reduce MACE at three-year follow-up compared with a more conservative strategy. The rate of MACE in the invasive group was predominantly driven by death and re-infarction, whereas in the conservative group the rate of MACE was only driven by repeat interventions.
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Metagegevens
Titel
Treatment of non-culprit lesions detected during primary PCI: long-term follow-up of a randomised clinical trial
Auteurs
A. Ghani
J-H. E. Dambrink
A. W. J. van ’t Hof
J. P. Ottervanger
A. T. M. Gosselink
J. C. A. Hoorntje
Publicatiedatum
01-09-2012
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 9/2012
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-012-0281-y