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18-09-2019 | Original Paper | Uitgave 1/2020

Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 1/2020

Auteurs:: A. E. Shindler, E. L. Hill-Yardin, S. Petrovski, N. Bishop, A. E. Franks

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The online version of this article (https://doi.org/10.1007/s10803-019-04231-6) contains supplementary material, which is available to authorized users.

N. Bishop and A. E. Franks contributed equally as senior author.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate statistical significance for the Prolactin (PRL) (OR 6.35, p value 0.069) and Interleukin 10 (IL-10) (OR 0.25, p value 0.087) SNPs. The GI dysfunction group had a strong statistical significance for the Cluster of Differentiation 38 (CD38) (OR 6.88, p value 0.005) and oxytocin receptor (OXTR) (OR 0.27, p value 0.036) SNPs. The potential use of PRL, IL-10, CD38, and OXTR SNP expression as biomarkers for GI dysfunction in autism warrants further research.

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Titel: Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism
Auteurs:: A. E. Shindler
E. L. Hill-Yardin
S. Petrovski
N. Bishop
A. E. Franks
Publicatiedatum: 18-09-2019
DOI: https://doi.org/10.1007/s10803-019-04231-6
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 1/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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