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08-01-2019 | OriginalPaper | Uitgave 5/2019 Open Access

Journal of Autism and Developmental Disorders 5/2019

Toddler Screening for Autism Spectrum Disorder: A Meta-Analysis of Diagnostic Accuracy

Journal of Autism and Developmental Disorders > Uitgave 5/2019
Ana B. Sánchez-García, Purificación Galindo-Villardón, Ana B. Nieto-Librero, Helena Martín-Rodero, Diana L. Robins
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The online version of this article (https://​doi.​org/​10.​1007/​s10803-018-03865-2) contains supplementary material, which is available to authorized users.

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Great efforts focus on early detection of autism spectrum disorder, although some scientists and policy-makers have questioned early universal screening. The aim of this meta-analysis was to evaluate the diagnostic accuracy of the different screening tools. Several electronic databases were used to identify published studies. A Bayesian model was used to estimate the screening accuracy. The pooled sensitivity was 0.72 (95% CI 0.61–0.81), and the specificity was 0.98 (95% CI 0.97–0.99). Subgroup analyses to remove heterogeneity indicated sensitivity was 0.77 (95% CI 0.69–0.84), and specificity was 0.99 (95% CI 0.97–0.99; SD ≤ 0.01). Level 1 screening tools for ASD showed consistent statistically significant results and therefore are adequate to detect autism at 14–36 months.

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