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2014 | OriginalPaper | Hoofdstuk

8. Therapeutics

Auteur : Paul A. Rosenberg, DDS

Gepubliceerd in: Endodontic Pain

Uitgeverij: Springer Berlin Heidelberg

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Abstract

This chapter reviews pharmacologic strategies including the use and abuse of antibiotics and analgesics. New guidelines are available to describe the indications for antibiotics. Antibiotics should be thought of as a supplement to clinical procedures in specific situations. The chapter explains why antibiotics should not be thought of as a means of “curing” an endodontic infection. The relationship of antibiotics, bacterial susceptibility, and acute abscesses is considered and evidence-based principles of antibiotic dosing are suggested.
Analgesics are presented as part of a pain-preventive (preemptive) strategy, in contrast to the historic use of analgesics only after a patient develops pain. Useful clinical tips include the advice that analgesics should be taken by the clock rather than only when a patient experiences pain.
Also reviewed is current evidence-based research supporting the use of a combination of acetaminophen and ibuprofen, to prevent and/or treat pain. That strategy is compared to the traditional use of narcotic agents to treat pain. Issues associated with addiction and drug overdose are also discussed.
Also discussed in this chapter is recent evidence concerning possible complications associated with the use of NSAIDs and acetaminophen in pregnant women and children as is evidence of sex bias in analgesic research.
Literatuur
1.
go back to reference ADA/AAOS antibiotic prophylaxis guideline for dental patients with orthopedic implants (2013). J Can Dent Assoc 79:d28 ADA/AAOS antibiotic prophylaxis guideline for dental patients with orthopedic implants (2013). J Can Dent Assoc 79:d28
2.
go back to reference Baumgartner JC, Xia T (2003) Antibiotic susceptibility of bacteria associated with endodontic abscesses. J Endod 29(1):44–47PubMedCrossRef Baumgartner JC, Xia T (2003) Antibiotic susceptibility of bacteria associated with endodontic abscesses. J Endod 29(1):44–47PubMedCrossRef
4.
go back to reference Czerwinski AW, Czerwinski AB, Whitsett TL et al (1972) Effects of a single, large, intravenous injection of dexamethasone. Clin Pharmacol Ther 13(5):638–642PubMed Czerwinski AW, Czerwinski AB, Whitsett TL et al (1972) Effects of a single, large, intravenous injection of dexamethasone. Clin Pharmacol Ther 13(5):638–642PubMed
5.
go back to reference Daniels SE, Goulder MA, Aspley S et al (2011) A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain 152(3):632–642PubMedCrossRef Daniels SE, Goulder MA, Aspley S et al (2011) A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain 152(3):632–642PubMedCrossRef
6.
go back to reference Dionne RA (1992) New approaches to preventing and treating postoperative pain. J Am Dent Assoc 123(6):26–34PubMed Dionne RA (1992) New approaches to preventing and treating postoperative pain. J Am Dent Assoc 123(6):26–34PubMed
7.
go back to reference Fillingim RB, King CD, Ribeiro-Dasilva MC et al (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10(5):447–485PubMedCentralPubMedCrossRef Fillingim RB, King CD, Ribeiro-Dasilva MC et al (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10(5):447–485PubMedCentralPubMedCrossRef
8.
go back to reference Forman JP, Rimm EB, Stampfer MJ et al (2005) Folate intake and the risk of incident hypertension among US women. JAMA 293(3):320–329PubMedCrossRef Forman JP, Rimm EB, Stampfer MJ et al (2005) Folate intake and the risk of incident hypertension among US women. JAMA 293(3):320–329PubMedCrossRef
9.
go back to reference Gutierrez JL, Bagan JV, Bascones A et al (2006) Consensus document on the use of antibiotic prophylaxis in dental surgery and procedures. Med Oral Patol Oral Cir Bucal 11(2):E188–E205PubMed Gutierrez JL, Bagan JV, Bascones A et al (2006) Consensus document on the use of antibiotic prophylaxis in dental surgery and procedures. Med Oral Patol Oral Cir Bucal 11(2):E188–E205PubMed
10.
go back to reference Hargreaves KM, Cohen S, Berman LH (2011) Cohen’s pathways of the pulp. Mosby Elsevier, St. Louis Hargreaves KM, Cohen S, Berman LH (2011) Cohen’s pathways of the pulp. Mosby Elsevier, St. Louis
11.
go back to reference Henderson AJ, Shaheen SO (2013) Acetaminophen and asthma. Paediatr Respir Rev 14(1):9–15, quiz 16PubMedCrossRef Henderson AJ, Shaheen SO (2013) Acetaminophen and asthma. Paediatr Respir Rev 14(1):9–15, quiz 16PubMedCrossRef
12.
go back to reference Little JW, Falace DA, Miller C et al (2012) Dental management of the medically compromised patient. Mosby, St. Louis Little JW, Falace DA, Miller C et al (2012) Dental management of the medically compromised patient. Mosby, St. Louis
13.
go back to reference Marshall JG (2002) Considerations of steroids for endodontic pain. Endod Top 3:41CrossRef Marshall JG (2002) Considerations of steroids for endodontic pain. Endod Top 3:41CrossRef
14.
go back to reference Mehlisch DR, Aspley S, Daniels SE et al (2010) Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study. Clin Ther 32(5):882–895PubMedCrossRef Mehlisch DR, Aspley S, Daniels SE et al (2010) Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study. Clin Ther 32(5):882–895PubMedCrossRef
15.
go back to reference Menhinick KA, Gutmann JL, Regan JD et al (2004) The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study. Int Endod J 37(8):531–541PubMedCrossRef Menhinick KA, Gutmann JL, Regan JD et al (2004) The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study. Int Endod J 37(8):531–541PubMedCrossRef
16.
go back to reference Mogil JS, Chanda ML (2005) The case for the inclusion of female subjects in basic science studies of pain. Pain 117(1–2):1–5PubMedCrossRef Mogil JS, Chanda ML (2005) The case for the inclusion of female subjects in basic science studies of pain. Pain 117(1–2):1–5PubMedCrossRef
17.
go back to reference Moore PA, Hersh EV (2013) Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc 144(8):898–908PubMedCrossRef Moore PA, Hersh EV (2013) Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc 144(8):898–908PubMedCrossRef
18.
go back to reference Moore PA, Werther JR, Seldin EB et al (1986) Analgesic regimens for third molar surgery: pharmacologic and behavioral considerations. J Am Dent Assoc 113(5):739–744PubMed Moore PA, Werther JR, Seldin EB et al (1986) Analgesic regimens for third molar surgery: pharmacologic and behavioral considerations. J Am Dent Assoc 113(5):739–744PubMed
19.
go back to reference Nagle D, Reader A, Beck M et al (2000) Effect of systemic penicillin on pain in untreated irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(5):636–640PubMedCrossRef Nagle D, Reader A, Beck M et al (2000) Effect of systemic penicillin on pain in untreated irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(5):636–640PubMedCrossRef
20.
go back to reference Nezvalova-Henriksen K, Spigset O, Nordeng H (2013) Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. BJOG 120(8):948–959PubMedCrossRef Nezvalova-Henriksen K, Spigset O, Nordeng H (2013) Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. BJOG 120(8):948–959PubMedCrossRef
21.
go back to reference Niesters M, Dahan A, Kest B et al (2010) Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain 151(1):61–68PubMedCrossRef Niesters M, Dahan A, Kest B et al (2010) Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain 151(1):61–68PubMedCrossRef
22.
go back to reference Okeson JP, Falace DA (1997) Nonodontogenic toothache. Dent Clin North Am 41(2):367–383PubMed Okeson JP, Falace DA (1997) Nonodontogenic toothache. Dent Clin North Am 41(2):367–383PubMed
23.
go back to reference Pizzo PA, Clark NM (2012) Alleviating suffering 101–pain relief in the United States. N Engl J Med 366(3):197–199PubMedCrossRef Pizzo PA, Clark NM (2012) Alleviating suffering 101–pain relief in the United States. N Engl J Med 366(3):197–199PubMedCrossRef
24.
go back to reference Reader A, Nusstein J, Drum M (2011) Successful local anesthesia for restorative dentistry and endodontics. Quintessence, Chicago Reader A, Nusstein J, Drum M (2011) Successful local anesthesia for restorative dentistry and endodontics. Quintessence, Chicago
25.
go back to reference Riley JL, Gilbert GH (2001) Orofacial pain symptoms: an interaction between age and sex. Pain 90(3):245–256PubMedCrossRef Riley JL, Gilbert GH (2001) Orofacial pain symptoms: an interaction between age and sex. Pain 90(3):245–256PubMedCrossRef
26.
go back to reference Thiele K, Kessler T, Arck P et al (2013) Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J Reprod Immunol 97(1):128–139PubMedCrossRef Thiele K, Kessler T, Arck P et al (2013) Acetaminophen and pregnancy: short- and long-term consequences for mother and child. J Reprod Immunol 97(1):128–139PubMedCrossRef
27.
go back to reference Wall PD, McMahon SB, Koltzenburg M (2006) Wall and Melzack’s textbook of pain. Elsevier/Churchill Livingstone, Philadelphia Wall PD, McMahon SB, Koltzenburg M (2006) Wall and Melzack’s textbook of pain. Elsevier/Churchill Livingstone, Philadelphia
28.
go back to reference Williamson LW, Lorson EL, Osbon DB (1980) Hypothalamic-pituitary-adrenal suppression after short-term dexamethasone therapy for oral surgical procedures. J Oral Surg 38(1):20–28PubMed Williamson LW, Lorson EL, Osbon DB (1980) Hypothalamic-pituitary-adrenal suppression after short-term dexamethasone therapy for oral surgical procedures. J Oral Surg 38(1):20–28PubMed
29.
go back to reference Wynn RL, Meiller TF, Crossley HL (2012) Drug information handbook for dentistry: including oral medicine for medically compromised patients & specific oral conditions. Lexi Comp, Hudson Wynn RL, Meiller TF, Crossley HL (2012) Drug information handbook for dentistry: including oral medicine for medically compromised patients & specific oral conditions. Lexi Comp, Hudson
Metagegevens
Titel
Therapeutics
Auteur
Paul A. Rosenberg, DDS
Copyright
2014
Uitgeverij
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-54701-0_8