Swipe om te navigeren naar een ander artikel
Contrast enhancement by microbubble infusion has proven its applicability in the field of diagnostic ultrasound. Recent studies also indicate a therapeutic effect of the combined use of ultrasound and microbubbles. Results from animal studies demonstrate that diagnostic ultrasound in combination with intravenous microbubbles can dissolve thrombi. So far, this effect has never been tested in patients with an acute ST-elevation myocardial infarction (STEMI). We recently launched a pilot study in acute STEMI patients to assess safety, feasibility and efficacy of the treatment in this patient group with transthoracic three-dimensional diagnostic ultrasound and intravenous microbubbles immediately after prehospital thrombolysis, but prior to primary percutaneous coronary intervention.
Becher H, Burns PN. Contrast Agents for Echocardiography: Principles and Instrumentation. Handbook of Contrast Echocardiography: Left Ventricular Function and Myocardial Perfusion. Frankfurt and New York: 2000. p. 1–45.
Tachibana K, Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation. 1995;92(5):1148–50. PubMed
Juffermans LJM. Ultrasound and microbubble-targeted delivery of drugs and genes VU University Medical Center, Amsterdam, the Netherlands; 6-4-2009.Ph.D. dissertation
An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators. N Engl J Med. 1993;329(10):673–82. CrossRef
Slikkerveer J, Xie F, Kamp O, et al. Improvement in myocardial blood volume and ultimate infarct size despite persistent epicardial occlusion using three-dimensional transthoracic ultrasound and intravenous non-targeted microbubbles. Eur Heart J. 2010;31 suppl 1:873–1071.
Birnbaum Y, Luo H, Nagai T, et al. Noninvasive in vivo clot dissolution without a thrombolytic drug: recanalization of thrombosed iliofemoral arteries by transcutaneous ultrasound combined with intravenous infusion of microbubbles. Circulation. 1998;97(2):130–4. PubMed
- Therapeutic application of ultrasound: contrast-enhanced thrombolysis in acute ST-elevation myocardial infarction; the Sonolysis study
N. van Royen
- Bohn Stafleu van Loghum