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01-11-2014 | Uitgave 9/2014

Quality of Life Research 9/2014

The VEINES-QOL/Sym questionnaire is a reliable and valid disease-specific quality of life measure for deep vein thrombosis in elderly patients

Quality of Life Research > Uitgave 9/2014
M. Méan, A. Limacher, S. R. Kahn, D. Aujesky
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s11136-014-0704-x) contains supplementary material, which is available to authorized users.



To prospectively evaluate the psychometric properties of the Venous Insufficiency Epidemiological and Economic Study (VEINES-QOL/Sym) questionnaire, an instrument to measure disease-specific quality of life and symptoms in elderly patients with deep vein thrombosis (DVT), and to validate a German version of the questionnaire.


In a prospective multicenter cohort study of patients aged ≥65 years with acute venous thromboembolism, we used standard psychometric tests and criteria to evaluate the reliability, validity, and responsiveness of the VEINES-QOL/Sym in patients with acute symptomatic DVT. We also performed an exploratory factor analysis.


Overall, 352 French- and German-speaking patients were enrolled (response rate of 87 %). Both language versions of the VEINES-QOL/Sym showed good acceptability (missing data, floor and ceiling effects), reliability (internal consistency, item-total and inter-item correlations), validity (convergent, discriminant, known-groups differences), and responsiveness to clinical change over time in elderly patients with DVT. The exploratory factor analysis of the VEINES-QOL/Sym suggested three underlying dimensions: limitations in daily activities, DVT-related symptoms, and psychological impact.


The VEINES-QOL/Sym questionnaire is a practical, reliable, valid, and responsive instrument to measure quality of life and symptoms in elderly patients with DVT and can be used with confidence in prospective studies to measure outcomes in such patients.

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Extra materiaal
Supplementary material 1 (DOCX 19 kb)
Supplementary material 2 (DOCX 23 kb)
Supplementary material 3 (PDF 41 kb)
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