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Gepubliceerd in: Quality of Life Research 3/2008

01-04-2008

The validity of generic and condition-specific preference-based instruments: the ability to discriminate asthma control status

Auteurs: Helen M. McTaggart-Cowan, Carlo A. Marra, Yaling Yang, John E. Brazier, Jacek A. Kopec, J. Mark FitzGerald, Aslam H. Anis, Larry D. Lynd

Gepubliceerd in: Quality of Life Research | Uitgave 3/2008

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Abstract

Objective

A goal of asthma management is to improve the patient’s health-related quality of life (HRQL). However, it is unclear whether HRQL instruments can discriminate across asthma control measures. The objective of this study was to evaluate the validity of generic and condition-specific preference-based instruments, in terms of their ability to distinguish asthma control.

Methods

Asthma patients (n = 157) completed three generic preference-based instruments: the Health Utility Index Mark 3 (HUI-3), the EuroQol (EQ-5D), and the Short Form 6D (SF-6D) and two condition-specific questionnaires: the standardized Asthma Quality of Life Questionnaire (AQLQ(S)) and the Asthma Control Questionnaire (ACQ). The AQLQ(S) scores were converted into the condition-specific preference-based scores: the Asthma Quality of Life Utility Index (AQL-5D).

Results

The preference-based instruments were generally able to discriminate across control measures, such as ACQ scores and magnitude of asthma medication, but were not able to discriminate for self-reported control and severity levels. These instruments also correlated with most control measures (r = 0.32–0.37). Significant relationships between AQL-5D scores and all control variables were observed.

Conclusions

Overall, the AQL-5D discriminated across all levels of asthma control. The HUI-3, the EQ-5D, and the SF-6D differentiated between the highest and lowest levels of control but could not discriminate between the moderate levels.
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Metagegevens
Titel
The validity of generic and condition-specific preference-based instruments: the ability to discriminate asthma control status
Auteurs
Helen M. McTaggart-Cowan
Carlo A. Marra
Yaling Yang
John E. Brazier
Jacek A. Kopec
J. Mark FitzGerald
Aslam H. Anis
Larry D. Lynd
Publicatiedatum
01-04-2008
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 3/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-008-9309-6

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