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01-02-2014 | Original Paper

The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder

Auteurs: Sophie van Rijn, Lex Stockmann, Martine Borghgraef, Hilgo Bruining, Conny van Ravenswaaij-Arts, Lutgarde Govaerts, Kerstin Hansson, Hanna Swaab

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2014

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Abstract

The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.
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Metagegevens
Titel
The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder
Auteurs
Sophie van Rijn
Lex Stockmann
Martine Borghgraef
Hilgo Bruining
Conny van Ravenswaaij-Arts
Lutgarde Govaerts
Kerstin Hansson
Hanna Swaab
Publicatiedatum
01-02-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1860-5