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Child Psychiatry & Human Development
Gepubliceerd in: Child Psychiatry & Human Development 5/2014

01-10-2014 | Original Article

The Sex Ratio of Full and Half Siblings of People Diagnosed with an Autism Spectrum Disorder: A Danish Nationwide Register Study

Auteurs: Svend Erik Mouridsen, Bente Rich, Torben Isager

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 5/2014

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Abstract

In the extreme male brain theory of autism sex steroid hormones are hypothesized to influence brain development and to mediate sex differences in developmental psychopathology. Within this scope we examined the sex ratio (proportion of males) in siblings of individuals diagnosed with autism spectrum disorders (ASD). We did a nationwide, register based cohort study of the sex ratio in 17,380 siblings of the 10,297 patients diagnosed with ASD at age 17 years and younger and registered in the nationwide Danish Psychiatric Central Register between 1994 and 2012. Among the 17,380 siblings 8,828 were males and 8,552 females. This yields a sex ratio of 0.508, which is not different from the Danish live birth sex ratio of 0.513 during the relevant years (P = 0.18). Overall, our findings provide no support for the hypothesis that there are relatively more males among the siblings of people with ASD. Accordingly, our results do not give support to the extreme male brain theory of autism.
volgende artikel Ecological Correlates of Depression and Self-Esteem in Rural Youth
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Metagegevens
Titel
The Sex Ratio of Full and Half Siblings of People Diagnosed with an Autism Spectrum Disorder: A Danish Nationwide Register Study
Auteurs
Svend Erik Mouridsen
Bente Rich
Torben Isager
Publicatiedatum
01-10-2014
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 5/2014
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-013-0419-1

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