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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2011

01-07-2011 | Original Paper

The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism

Auteurs: Linda Dodds, Deshayne B. Fell, Sarah Shea, B. Anthony Armson, Alexander C. Allen, Susan Bryson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2011

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Abstract

We conducted a linked database cohort study of infants born between 1990 and 2002 in Nova Scotia, Canada. Diagnoses of autism were identified from administrative databases with relevant diagnostic information to 2005. A factor representing genetic susceptibility was defined as having an affected sibling or a mother with a history of a psychiatric or neurologic condition. Among 129,733 children, there were 924 children with an autism diagnosis. The results suggest that among those with low genetic susceptibility, some maternal and obstetric factors may have an independent role in autism etiology whereas among genetically susceptible children, these factors appear to play a lesser role. The role of pre-pregnancy obesity and excessive weight gain during pregnancy on autism risk require further investigation.
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Metagegevens
Titel
The Role of Prenatal, Obstetric and Neonatal Factors in the Development of Autism
Auteurs
Linda Dodds
Deshayne B. Fell
Sarah Shea
B. Anthony Armson
Alexander C. Allen
Susan Bryson
Publicatiedatum
01-07-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1114-8

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