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01-10-2016 | Uitgave 10/2016

Quality of Life Research 10/2016

The relative impact of chronic conditions and multimorbidity on health-related quality of life in Ontario long-stay home care clients

Quality of Life Research > Uitgave 10/2016
Luke Mondor, Colleen J. Maxwell, Susan E. Bronskill, Andrea Gruneir, Walter P. Wodchis



To examine the relative impact of 16 common chronic conditions and increasing morbidity on health-related quality of life (HRQL) in a population-based sample of home care clients in Ontario, Canada.


Participants were adult clients assessed with the Resident Assessment Instrument for Home Care (RAI-HC) between January and June 2009 and diagnosed with one (or more) of 16 common chronic conditions. HRQL was evaluated using the Minimum Data Set-Health Status Index (MDS-HSI), a preference-based measure derived from items captured in the RAI-HC. Multivariable linear regression models assessed the relative impact of each condition, and increasing number of diagnoses, on MDS-HSI scores.


Mean (SD) MDS-HSI score in the study population (n = 106,159) was 0.524 (0.213). Multivariable analysis revealed a statistically significant (p < 0.05) and clinically important (difference ≥ 0.03) decrease in MDS-HSI scores associated with stroke (−0.056), osteoarthritis (−0.036), rheumatoid arthritis (−0.033) and congestive heart failure (CHF, −0.030). Differences by age and sex were observed; most notably, the negative impact associated with dementia was greater among men (−0.043) than among women (−0.019). Further, HRQL decreased incrementally with additional diagnoses. In all models, chronic conditions and number of diagnoses accounted for a relatively small proportion of the variance observed in MDS-HSI.


Clinically important negative effects on HRQL were observed for clients with a previous diagnosis of stroke, osteo- and rheumatoid arthritis, or CHF, as well as with increasing levels of multimorbidity. Findings provide baseline preference-based HRQL scores for home care clients with different diagnoses and may be useful for identifying, targeting and evaluating care strategies toward populations with significant HRQL impairments.

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