Swipe om te navigeren naar een ander artikel
The purpose of this longitudinal study was to investigate quality of life (QOL) before, during, and after the course of radiotherapy (RT) and to identify risk factors for diminished QOL in women with breast cancer.
Patients (N = 188) completed the short-form 12 (SF-12), the Karnofsky Performance Status Scale, Memorial Symptom Assessment Scale, and the Self-Administrated Comorbidity Questionnaire 1 week prior to the start of RT. To assess changes in QOL, patients also completed the SF-12 1, 2, 3, and 6 months after the baseline. A random-intercept and slope model (mixed model) for each patient was used to estimate linear trends for the mental component score and physical component score of QOL (five time points for each patient). Descriptive statistics were used to analyze demographic and clinical characteristics.
The physical component score (PCS) did not change significantly (p = 0.078) during the course of RT in women with breast cancer. An increase in the number of symptoms and a higher comorbidity profile was negatively related to the PCS. The mental component score (MCS) did not change from the start of RT until the 2-month assessment, but increased significantly after 2 months (p = 0.044). An increase in the number of symptoms was negatively related to the MCS.
The MCS and PCS of QOL remained stable at a diminished level except for the MCS which improved between 2 and 6 months after the start of RT. The total number of symptoms was the only variable that was negatively associated with both component scores (MCS and PCS) during the 6 months.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Noal, S., Levy, C., Hardouin, A., Rieux, C., Heutte, N., Segura, C., et al. (2011). One-year longitudinal study of fatigue, cognitive functions, and quality of life after adjuvant radiotherapy for breast cancer. International Journal of Radiation Oncology Biology Physics, 81(3), 795–803. CrossRef
Parker, P. A., Youssef, A., Walker, S., Basen-Engquist, K., Cohen, L., Gritz, E. R., et al. (2007). Short-term and long-term psychosocial adjustment and quality of life in women undergoing different surgical procedures for breast cancer. Annals of Surgical Oncology, 14(11), 3078–3089. PubMedCrossRef
Clinical Gov.Trial. (2013). webpage [Electronic version]. http://www.clinicaltrials.gov/ct2/results?term=NCT00769301&Search=Search.
Schag, C. C., Heinrich, R. L., & Ganz, P. A. (1984). Karnofsky Performance Status revisited: Reliability, validity, and guidelines. Journal of Clinical Oncology, 2(3), 187–193. PubMed
Portenoy, R. K., Thaler, H. T., Kornblith, A. B., Lepore, J. M., Friedlander-Klar, H., Kiyasu, E., et al. (1994). The Memorial Symptom Assessment Scale: An instrument for the evaluation of symptom prevalence, characteristics and distress. European Journal of Cancer, 30A(9), 1326–1336. PubMedCrossRef
Ware, J. E., Kosinski, M., & Keller, S. D. (1996). A 12- item, short-form health survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 3, 220–223. CrossRef
Naume B (2010). www.oncolex.no. webpage [Electronic version]. http://www.oncolex.no/Bryst/Prosedyrekatalog/BEHANDLING/Medikamentell%20behandling/Adjuvant%20behandling%20bryst.aspx?lg=procedure.
Breast Cancer Org. (2010). webpage [Electronic version]. http://www.breastcancer.org/symptoms/types/dcis/diagnosis.jsp.
Mapi Research Institute (2004). Mapi Institute linguistic validation. [Electronic version] www.mapi-trust.com.
Gandek, B., Ware, J. E., Aaronson, N. K., Apolone, G., Bjorner, J. B., Brazier, J. E., et al. (1998). Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: Results from the IQOLA Project. International Quality of Life Assessment. Journal of Clinical Epidemiology, 51(11), 1171–1178. PubMedCrossRef
Ware, J. E., Kosinski, M., & Keller, S. D. (1995). How to score the SF-12 physical and mental summary scales. Boston, MA: New England Medical Center, Health Institute.
Ware, J. E., Kosinski, M, Jr, Turner-Bowker, D. M., & Gandek, B. (2007). User’s manual for the SF-12v2 Health Survey (with a supplement documenting SF-12 Health Survey). Boston, MA: Quality Metric Incorporated, Lincoln, Rhode Island and Health Assessment Lab.
Rabe-Hesketh, S., & Skrondal, A. (2008). Multilevel and longitudinal modeling using Stata (2nd ed.). College Station: Stata Press.
Corp, S. (2009). STATA statistical software. College Station, TX: Stata Corporation LP.
Ganz, P. A., Kwan, L., Stanton, A. L., Krupnick, J. L., Rowland, J. H., Meyerowitz, B. E., et al. (2004). Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial. Journal of the National Cancer Institute, 96(5), 376–387. PubMedCrossRef
Bower, J. E., Ganz, P. A., Desmond, K. A., Rowland, J. H., Meyerowitz, B. E., & Belin, T. R. (2000). Fatigue in breast cancer survivors: Occurrence, correlates, and impact on quality of life. Journal of Clinical Oncology, 18(4), 743–753. PubMed
Norwegian Breast Cancer Group (NBCG). (2010). webpage [Electronic version]. http://www.nbcg.no/nbcg.blaaboka.html.
- The relationships between demographic and clinical characteristics and quality of life during and after radiotherapy: in women with breast cancer
Lien My Diep
- Springer International Publishing