Top

Gepubliceerd in:

20-02-2021

The relationship between sleep and opioids in chronic pain patients

Auteurs: Amy Frers, Jonathan Shaffer, Jack Edinger, Amy Wachholtz

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 3/2021

Abstract

Background. Sleep problems are common among chronic pain patients who take opioids. There are documented effects of opioids on sleep architecture; however, the long-term effects of opioids on sleep remain unknown. This study examined whether opioid-naïve participants have better sleep quality than current and previous chronic users of opioids. We also explored whether sleep differed between methadone and buprenorphine users, and whether amount of time since abstaining from opioids was associated with sleep quality. Method. Participants were 120 people with chronic pain (84.2% Caucasian, M_age = 42.0 years, SD = 11.44). They were in one of four groups of 30 participants each: (1) current users of methadone for opioid use disorder (OUD); (2) current users of buprenorphine for OUD; (3) a history of medication-assisted therapy for OUD but currently opioid-abstinent for at least 6 months; (4) those who have less than one month of cumulative lifetime opioids (opioid-naïve group). Only participants in group 1 and group 2 were taking opioids during the time of the study. Participants completed the Pittsburgh Sleep Quality Index and the SF-36. Results. A MANCOVA revealed that all three groups with current or previous opioid use (i.e., groups 1–3) differed significantly from the opioid-naïve group (group 4) on sleep quality, sleep duration, sleep disturbances, and daytime dysfunction after controlling for sleep medications (all p < .05). For group 1 (methadone users), 2 (buprenorphine users), and 3 (prolonged abstinence), there were no statistically significant differences between each group. There was also a significant relationship between opioid-abstinent weeks and sleep disturbances in the opioid-abstinent group (r = − 0.604, p < .001). Discussion. The results of this study suggest that opioids interfere with sleep quality, even after months of abstention. Further research into the long-term effects of opioids is warranted and may contribute further to the importance of addressing sleep problems in this population.

vorige artikel Diabetes-specific friend support in emerging adults with type 1 diabetes: Does satisfaction with support matter?

volgende artikel Psychosocial interventions to reduce eating pathology in bariatric surgery patients: a systematic review

Backhaus, J., Junghanns, K., Broocks, A., Riemann, D., & Hohagen, F. (2002). Test–retest reliability and validity of the Pittsburgh sleep quality index in primary insomnia. Journal of Psychosomatic Research, 53, 737. https://doi.org/10.1016/S0022-3999(02)00330-6.CrossRefPubMed

Bailey, A., Matthes, H., Kieffer, B., Slowe, S., Hourani, S. M. O., & Kitchen, I. (2002). Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains and spinal cords of mice deficient in the mu-opioid receptor gene. Brain research, 943(1), 68–79. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med4&NEWS=N&AN=12088840.

Baron, R. M., & Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of personality and social psychology, 51, 1173. https://doi.org/10.1037//0022-3514.51.6.1173.CrossRefPubMed

Benyamin, R., Trescot, A., Sukdeb, D., Buenaventura, R., Adlaka, R., Sehgal, N., & Vallejo, R. (2008). Opioid complications and side effects. Pain physician, 11, S105–S120.CrossRef

Brazier, J. E., Harper, R., Jones, N. M., Cathain, A., Thomas, K. J., Usherwood, T., & Westlake, L. (1992). Validating the SF-36 health survey questionnaire: New outcome measure for primary care. British Medical Journal, 305, 160. https://doi.org/10.1136/bmj.305.6846.160.CrossRefPubMed

Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193. https://doi.org/10.1016/0165-1781(89)90047-4.CrossRefPubMed

Deering, D. E., Frampton, C. M. A., Horn, J., Sellman, J. D., Adamson, S. J., & Potiki, T. L. (2004). Health status of clients receiving methadone maintenance treatment using the SF-36 health survey questionnaire. Drug and Alcohol Review, 23, 273. https://doi.org/10.1080/09595230412331289428.CrossRefPubMed

Dimsdale, J., Norman, D., DeJardin, D., & Wallace, M. (2007). The effect of opioids on sleep architecture. Retrieved from http://www.aasmnet.org/JCSM/Articles/030106.pdf.

Drum. . (1999). The chronic pain management sourcebook. Los Angeles: Lowell House.

Durmer, J. S., & Dinges, D. F. (2005). Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 25, 117. https://doi.org/10.1055/s-2005-867080.CrossRefPubMed

Elliott, T. E., Renier, C. M., & Palcher, J. A. (2003). Chronic pain, depression, and quality of life: Correlations and predictive value of the SF-36. Pain Medicine, 4, 331. https://doi.org/10.1111/j.1526-4637.2003.03040.x.CrossRefPubMed

Finn, L., Young, T., Palta, M., & Fryback, D. G. (1998). Sleep-disordered breathing and self-reported general health status in the wisconsin sleep cohort study. Sleep, 21, 701. https://doi.org/10.1093/sleep/21.7.701.CrossRefPubMed

Gaskin, D. J., & Richard, P. (2011). The economic costs of pain in the United States. In: Institute of Medicine (US) Committee on Advancing pain research, care, and education. relieving pain in America: A blueprint for transforming prevention, care, education, and research. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK92521/.

GauthierElizabeth, A. B. S., GuzickSarah, E. B. S., BrummettChad, M. M. D., BaghdoyanHelen, A. P. D., & Lydic, R. P. D. (2011). Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep regulating brain regions of sprague dawley rat. Anesthesiology: The Journal of the American Society of Anesthesiologists, 115, 743–753.CrossRef

Hahesy, A. L., Wilens, T. E., Biederman, J., Van Patten, S. L., & Spencer, T. (2002). Temporal association between childhood psychopathology and substance use disorders: Findings from a sample of adults with opioid or alcohol dependency. Psychiatry Research, 109, 245. https://doi.org/10.1016/S0165-1781(02)00015-X.CrossRefPubMed

Hayes, A. F. (2009). Beyond Baron and Kenny: Statistical mediation analysis in the new millennium. Communication Monographs, 76, 408. https://doi.org/10.1080/03637750903310360.CrossRef

Lee, M., Choh, A. C., Demerath, E. W., Knutson, K. L., Duren, D. L., Sherwood, R. J., & Czerwinski, S. A. (2009). Sleep disturbance in relation to health-related quality of life in adults: The Fels longitudinal study. The journal of nutrition, health & aging, 13, 576. https://doi.org/10.1007/s12603-009-0110-1.CrossRef

Mahfoud, Y., Talih, F., Streem, D., & Budur, K. (2009). Sleep disorders in substance abusers: How common are they? Psychiatry (Edgmont (Pa. : Township)), 6: 38–42. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19855859.

Maremmani, I., Pani, P. P., Pacini, M., & Perugi, G. (2007). Substance use and quality of life over 12 months among buprenorphine maintenance-treated and methadone maintenance-treated heroin-addicted patients. Journal of Substance Abuse Treatment, 33, 91. https://doi.org/10.1016/j.jsat.2006.11.009.CrossRefPubMed

McCracken, L. M., & Iverson, G. L. (2002). Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Research and Management, 7, 75. https://doi.org/10.1155/2002/579425.CrossRefPubMed

Mignot, E., Taheri, S., & Nishino, S. (2002). Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nature Neuroscience, 5, 1071. https://doi.org/10.1038/nn944.CrossRefPubMed

Morin. (2004). Cognitive-behavioral approaches to the treatment of insomnia. The Journal of clinical psychiatry, 65 Suppl 16, 33–40. Retrieved from http://europepmc.org/abstract/MED/15575803.

Morin, C. M., Gibson, D., & Wade, J. (1998). Self-reported sleep and mood disturbance in chronic pain patients. The Clinical journal of pain, 14, 311. https://doi.org/10.1097/00002508-199812000-00007.CrossRefPubMed

Nelson, A. M. B. A., Battersby, A. S. B. S., Baghdoyan, H. A. P. D., & Lydic, R. P. D. (2009). Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase. Anesthesiology: The Journal of the American Society of Anesthesiologists, 111, 1327–1333.CrossRef

Onen, S. H., Onen, F., Courpron, P., & Dubray, C. (2005). How pain and analgesics disturb sleep. The Clinical journal of pain, 21, 422. https://doi.org/10.1097/01.ajp.0000129757.31856.f7.CrossRefPubMed

Peles, E., Schreiber, S., & Adelson, M. (2009). Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. European Neuropsychopharmacology, 19, 581. https://doi.org/10.1016/j.euroneuro.2009.04.001.CrossRefPubMed

Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjørkum, A. A., Greene, R. W., & McCarley, R. W. (1997). Adenosine: A mediator of the sleep-inducing effects of prolonged wakefulness. Science, 276(5316), 1265. https://doi.org/10.1126/science.276.5316.1265.CrossRefPubMedPubMedCentral

Qaseem, A., Kansagara, D., Forciea, M. A., Cooke, M., & Denberg, T. D. (2016). Management of chronic insomnia disorder in adults: A clinical practice guideline from the american college of physicians management of chronic insomnia disorder in adults. Annals of Internal Medicine, 165(2), 125–133. https://doi.org/10.7326/M15-2175.CrossRefPubMed

Roehrs, T., Hyde, M., Blaisdell, B., Greenwald, M., & Roth, T. (2006). Sleep loss and REM sleep loss are hyperalgesic. Sleep, 29, 145. https://doi.org/10.1093/sleep/29.2.145.CrossRefPubMed

Roth, T., Hartse, K. M., Zorick, F., & Conway, W. (1980). Multiple naps and the evaluation of daytime sleepiness in patients with upper airway sleep apnea. Sleep, 3, 425. https://doi.org/10.1093/sleep/3.3-4.425.CrossRefPubMed

Sharkey, K. M., Kurth, M. E., Anderson, B. J., Corso, R. P., Millman, R. P., & Stein, M. D. (2011). Assessing sleep in opioid dependence: A comparison of subjective ratings, sleep diaries, and home polysomnography in methadone maintenance patients. Drug and Alcohol Dependence, 113, 245. https://doi.org/10.1016/j.drugalcdep.2010.08.007.CrossRefPubMed

Fei, T. B., & J., Yee, A., Habil, M. H. B., & Danaee, M. . (2016). Effectiveness of methadone maintenance therapy and improvement in quality of life following a decade of implementation. Journal of Substance Abuse Treatment, 69, 50. https://doi.org/10.1016/j.jsat.2016.07.006.CrossRef

Wachholtz, A., & Gonzalez, G. (2014). Co-morbid pain and opioid addiction: Long term effect of opioid maintenance on acute pain. Drug and Alcohol Dependence, 145, 143. https://doi.org/10.1016/j.drugalcdep.2014.10.010.CrossRefPubMedPubMedCentral

Walker, J. M., Farney, R. J., Rhondeau, S. M., Boyle, K. M., Valentine, K., Cloward, T. V., & Shilling, K. C. (2007). Chronic opioid use is a risk factor for the development of central sleep apnea and ataxic breathing. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 3: 455–461. Retrieved from http://europepmc.org/abstract/MED/17803007.

Walsh, S. L., Preston, K. L., Stitzer, M. L., Cone, E. J., & Bigelow, G. E. (1994). Clinical pharmacology of buprenorphine: Ceiling effects at high doses. Clinical Pharmacology & Therapeutics, 55, 569. https://doi.org/10.1038/clpt.1994.71.CrossRef

Ware, J. E., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Medical Care, 30, 473–483. https://doi.org/10.1097/00005650-199206000-00002.CrossRefPubMed

Wasan, A. D., Ross, E. L., Michna, E., Chibnik, L., Greenfield, S. F., Weiss, R. D., & Jamison, R. N. (2012). Craving of prescription opioids in patients with chronic pain: A longitudinal outcomes trial. The Journal of Pain, 13, 146. https://doi.org/10.1016/j.jpain.2011.10.010.CrossRefPubMedPubMedCentral

Titel: The relationship between sleep and opioids in chronic pain patients
Auteurs: Amy Frers
Jonathan Shaffer
Jack Edinger
Amy Wachholtz
Publicatiedatum: 20-02-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 3/2021
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-021-00205-1

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 3/2021

Diabetes burnout among emerging adults with type 1 diabetes: a mixed methods investigation

Anxiety sensitivity, pain severity and co-use of cigarettes and e-cigarettes among adults with chronic pain

Diabetes-specific friend support in emerging adults with type 1 diabetes: Does satisfaction with support matter?

Individual and joint associations of daily sleep and stress with daily well-being in hospital nurses: an ecological momentary assessment and actigraphy study

Cognitive and Affective Risk Beliefs and their Association with Protective Health Behavior in Response to the Novel Health Threat of COVID-19

Quantifying direct effects of social determinants of health on systolic blood pressure in United States adult immigrants