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30-08-2018

The prognostic value of health-related quality of life in patients with Chagas heart disease

Auteurs: Henrique Silveira Costa, Márcia Maria Oliveira Lima, Pedro Henrique Scheidt Figueiredo, Ana Thereza Chaves, Maria Carmo Pereira Nunes, Manoel Otávio da Costa Rocha

Gepubliceerd in: Quality of Life Research | Uitgave 1/2019

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Abstract

Purpose

To verify the prognostic value of health-related quality of life (HRQoL) and the differences in HRQoL and clinical variables between groups of Chagas heart disease (CHD) patients with and without cardiovascular adverse events.

Methods

Seventy-five CHD patients were evaluated by echocardiography, maximal exercise testing, and Short-form of Health Survey (SF-36) Questionnaire. Patients were followed during 6 years. In the statistical analysis, uni- and multivariate Cox regression were performed to verify the accuracy of the HRQoL in predicting cardiovascular events.

Results

After the follow-up period (41 ± 12 months), 20 patients (27%) had adverse events. Those with poor outcome had lower left ventricular ejection fraction (LVEF) (p = 0.002), higher left ventricular end-diastolic diameter (LVDd) (p = 0.019), and worse scores in general health perceptions (p = 0.047), social role functioning (p = 0.026), and mental component summary (p = 0.043) of SF-36. Patients with lower LVEF (p = 0.003), higher LVDd (p = 0.022), worse HRQoL in the general heath perceptions domain (p = 0.022), and mental component summary (p = 0.031) were associated with worse prognosis. In the multivariate Cox regression, LVEF (HR 0.94, 95% CI from 0.90 to 0.98, p = 0.007) and mental component summary (HR 0.98, 95% CI from 0.94 to 1.00, p = 0.047) remained as independent predictors of adverse events in CHD patients.

Conclusion

The assessment of HRQoL, especially the mental component, should be taken into account to provide an accurate prognosis in addition to other well-established predictors of poor outcomes in CHD patients.
Literatuur
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Metagegevens
Titel
The prognostic value of health-related quality of life in patients with Chagas heart disease
Auteurs
Henrique Silveira Costa
Márcia Maria Oliveira Lima
Pedro Henrique Scheidt Figueiredo
Ana Thereza Chaves
Maria Carmo Pereira Nunes
Manoel Otávio da Costa Rocha
Publicatiedatum
30-08-2018
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-018-1980-7