Swipe om te navigeren naar een ander artikel
To verify the prognostic value of health-related quality of life (HRQoL) and the differences in HRQoL and clinical variables between groups of Chagas heart disease (CHD) patients with and without cardiovascular adverse events.
Seventy-five CHD patients were evaluated by echocardiography, maximal exercise testing, and Short-form of Health Survey (SF-36) Questionnaire. Patients were followed during 6 years. In the statistical analysis, uni- and multivariate Cox regression were performed to verify the accuracy of the HRQoL in predicting cardiovascular events.
After the follow-up period (41 ± 12 months), 20 patients (27%) had adverse events. Those with poor outcome had lower left ventricular ejection fraction (LVEF) (p = 0.002), higher left ventricular end-diastolic diameter (LVDd) (p = 0.019), and worse scores in general health perceptions (p = 0.047), social role functioning (p = 0.026), and mental component summary (p = 0.043) of SF-36. Patients with lower LVEF (p = 0.003), higher LVDd (p = 0.022), worse HRQoL in the general heath perceptions domain (p = 0.022), and mental component summary (p = 0.031) were associated with worse prognosis. In the multivariate Cox regression, LVEF (HR 0.94, 95% CI from 0.90 to 0.98, p = 0.007) and mental component summary (HR 0.98, 95% CI from 0.94 to 1.00, p = 0.047) remained as independent predictors of adverse events in CHD patients.
The assessment of HRQoL, especially the mental component, should be taken into account to provide an accurate prognosis in addition to other well-established predictors of poor outcomes in CHD patients.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
American trypanosomiasis. CDC - Centers for Disease Control and prevention. (2016). Retrieved from https://www.cdc.gov/parasites/chagas/index.html. Accessed 31 Jul 2018.
Chagas, C. (1909). Nova tripanozomiaze humana: Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem. Memórias do Instituto Oswaldo Cruz, 1(2), 159–218. CrossRef
Dias, J. C. P., Ramos, A. N. Jr., Gontijo, E. D., Luquetti, A., Shikanai-Yasuda, M. A., Coura, J. R., et al. (2016). II Consenso Brasileiro em Doença de Chagas, 2015. Epidemiologia e Serviços de Saúde, 25, 7–86. PubMed
Oliveira, B. G., Abreu, M. N., Abreu, C. D., Rocha, M. O., & Ribeiro, A. L. (2011). Health-related quality of life in patients with Chagas disease. The Journal of the Brazilian Society of Tropical Medicine, 44(2), 150–156. PubMed
Sousa, G. R., Costa, H. S., Souza, A. C., Nunes, M. C. P., Lima, M. M. O., & Rocha, M. O. C. (2015). Health-related quality of life in patients with Chagas disease: A review of the evidence. The Journal of the Brazilian Society of Tropical Medicine, 48(2), 121–128. PubMed
The Criteria Committee of the New York Heart Association. (1994). Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. Boston, MA: Little, Brown & Co.
Szygula-Jurkiewicz, B., Zakliczynski, M., Owczarek, A., Partyka, R., Moscinski, M., Pudlo, R., et al. (2014). Low health-related quality of life is a predictor of major adverse cardiovascular events in patients with chronic nonischemic heart failure. Polish Journal of Cardio-Thoracic Surgery, 11(3), 283–288. CrossRefPubMed
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., et al. (2015). Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography, 28(1), 1–39 e14. CrossRefPubMed
ACSM. (2006). ACSM’s guidelines for exercise testing and exercise prescription (7th ed.). Philadelphia: Lippincott, Williams & Wilkins.
Ciconelli, R. M., Ferraz, M. B., Santos, W., Meinão, I., & Quaresma, M. R. (1997). Translation to Brazilian Portuguese and validation of the generic questionnaire to assessment quality of life—the SF-36 (SF-36 Brazil). Revsta Brasileira de Reumatologia, 39, 143–150.
- The prognostic value of health-related quality of life in patients with Chagas heart disease
Henrique Silveira Costa
Márcia Maria Oliveira Lima
Pedro Henrique Scheidt Figueiredo
Ana Thereza Chaves
Maria Carmo Pereira Nunes
Manoel Otávio da Costa Rocha
- Springer International Publishing
- Quality of Life Research
An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation - Official Journal of the International Society of Quality of Life Research
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649