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Gepubliceerd in: Journal of Behavioral Medicine 2/2015

01-04-2015

The placebo effect, sleep difficulty, and side effects: a balanced placebo model

Auteurs: Nadine Neukirch, Ben Colagiuri

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2015

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Abstract

Medical treatment is usually accompanied by a warning about potential side effects. While constituting an important component of informed consent, these warnings may themselves contribute to side effects via the placebo effect. We tested this possibility using a 2 × 2 between-subjects design. Under the guise of a trial of a new hypnotic, 91 undergraduates experiencing difficulty sleeping were allocated to receive a warning about a target side effect (either increase or decrease in appetite, counterbalanced) or no warning and then to receive placebo treatment or no treatment for one week. Placebo treatment led to significantly better sleep on almost all self-reported outcomes, suggesting a placebo effect for reported sleep difficulty. Actigraphy recordings were unaffected by treatment. There was a clear effect of the warning in that placebo treated participants who were warned about side effects were much more likely to report the target side effect than those not warned about side effects. Implications for clinical practice are discussed.
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Metagegevens
Titel
The placebo effect, sleep difficulty, and side effects: a balanced placebo model
Auteurs
Nadine Neukirch
Ben Colagiuri
Publicatiedatum
01-04-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 2/2015
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-014-9590-5