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Gepubliceerd in: Quality of Life Research 2/2018

02-08-2017

The Minneapolis-Manchester Quality of Life Instrument: reliability and validity of the Adult Form in cancer survivors

Auteurs: Alysia Bosworth, Elizabeth L. Goodman, Eric Wu, Liton Francisco, Leslie L. Robison, Smita Bhatia

Gepubliceerd in: Quality of Life Research | Uitgave 2/2018

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Abstract

Purpose

Childhood cancer survivors are at risk for deficits in health-related quality of life (HRQL) as they age. Youth (8–12 years) and adolescent (13–20 years) versions of the Minneapolis-Manchester Quality of Life Instrument (MMQL) have been developed to address survivor-specific issues and are currently in use; the MMQL-Adult Form has now been developed to assess HRQL in childhood cancer survivors aged 21–55 years.

Methods

The MMQL-Adult Form was administered to 499 adults: 65 cancer patients on-therapy, 107 off-therapy, and 327 healthy controls. Forty-four percent of patients were under 30 years old at cancer diagnosis. Principal components analysis was performed. We evaluated internal consistency reliability, stability (re-administration of the MMQL-Adult Form 2 weeks later), construct validity (concurrent administration of the SF-36), and known-groups validity (score comparisons across the three groups).

Results

Principal components analysis resulted in retention of 44 items across six scales: social functioning, physical functioning, cognitive functioning, outlook on life, body image, and psychological functioning. Internal consistency (Cronbach’s α) was 0.80–0.90 for individual scales and 0.95 overall. Strong intraclass correlations (0.98 overall) indicated high stability. The MMQL-Adult Form distinguished between known groups; healthy controls scored better than patients on four of six scales. The MMQL-Adult Form scales correlated highly with similar SF-36 scales, demonstrating construct validity.

Conclusions

The MMQL-Adult Form is a reliable and valid self-report instrument for measuring multidimensional HRQL in cancer survivors. Development of this instrument ensures availability of a tool enabling cross-sectional and longitudinal assessment of HRQL in childhood cancer survivors as they age.
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Metagegevens
Titel
The Minneapolis-Manchester Quality of Life Instrument: reliability and validity of the Adult Form in cancer survivors
Auteurs
Alysia Bosworth
Elizabeth L. Goodman
Eric Wu
Liton Francisco
Leslie L. Robison
Smita Bhatia
Publicatiedatum
02-08-2017
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1671-9

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