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01-10-2013

The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors

Auteurs: Tracy L. Gard, Donald R. Hoover, Qiuhu Shi, Mardge H. Cohen, Eugene Mutimura, Adebola A. Adedimeji, Kathryn Anastos

Gepubliceerd in: Quality of Life Research | Uitgave 8/2013

Abstract

Purpose

We examined whether established associations between HIV disease and HIV disease progression on worse health-related quality of life (HQOL) were applicable to women with severe trauma histories, in this case Rwandan women genocide survivors, the majority of whom were HIV-infected. Additionally, this study attempted to clarify whether post-traumatic stress symptoms were uniquely associated with HQOL or confounded with depression.

Methods

The Rwandan Women’s Interassociation Study and Assessment was a longitudinal prospective study of HIV-infected and uninfected women. At study entry, 922 women (705 HIV+ and 217 HIV−) completed measures of symptoms of post-traumatic stress and HQOL as well as other demographic, clinical, and behavioral characteristics.

Results

Even after controlling for potential confounders and mediators, HIV+ women, in particular those with the lowest CD4 counts, scored significantly worse on HQOL and overall quality of life (QOL) than did HIV− women. Even after controlling for depression and HIV disease progression, women with more post-traumatic stress symptoms scored worse on HQOL and overall QOL than women with fewer post-traumatic stress symptoms.

Conclusions

This study demonstrated that post-traumatic stress symptoms were independently associated with HQOL and overall QOL, independent of depression and other confounders or potential mediators. Future research should examine whether the long-term impact of treatment on physical and psychological symptoms of HIV and post-traumatic stress symptoms would generate improvement in HQOL.

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Titel: The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors
Auteurs: Tracy L. Gard
Donald R. Hoover
Qiuhu Shi
Mardge H. Cohen
Eugene Mutimura
Adebola A. Adedimeji
Kathryn Anastos
Publicatiedatum: 01-10-2013
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 8/2013
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-012-0328-y

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Abstract

Purpose

Methods

Results

Conclusions

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