Top

Quality of Life Research

Gepubliceerd in:

01-06-2008

The impact of chronic hepatitis C and co-morbid illnesses on health-related quality of life

Auteurs: Jeffrey W. Kwan, Ruth C. Cronkite, Antony Yiu, Mary K. Goldstein, Lewis Kazis, Ramsey C. Cheung

Gepubliceerd in: Quality of Life Research | Uitgave 5/2008

Abstract

Objectives

Determine the relative impact of chronic hepatitis C (CHC) and co-morbid illnesses on health-related quality of life (HRQoL) in 3023 randomly selected veterans with known hepatitis C virus antibody (anti-HCV) status who previously completed a veteran-specific HRQoL questionnaire (SF-36V).

Methods

Multiple regression analyses were performed to measure the relative contribution of anti-HCV status, four demographic variables, and ten common medical and six psychiatric co-morbidities to HRQoL between 303 anti-HCV(+) and 2720 anti-HCV(−) patients.

Results

Anti-HCV(+) veterans were younger, reported a lower HRQoL on seven of eight 36-Item Short Form Health Survey for Veterans (SF-36V) subscales (P ≤ 0.001) and the mental component summary (MCS) scale (P < 0.001). The ten medical and six psychiatric co-morbidities had variable impact on predicting lower HRQoL in both groups. After adjusting for demographic variables and co-morbid illnesses, we found that anti-HCV(+) patients reported a significantly lower MCS score (P < 0.001) and a trend toward a lower physical component summary (PCS) score (P < 0.07) compared to anti-HCV(−) veterans. Among the anti-HCV(+) veterans, co-morbid medical illnesses contributed to impaired PCS but not to MCS.

Conclusions

Veterans with CHC were younger than HCV(−) veterans and hence less likely to have other co-morbid medical illnesses. Medical co-morbidities seen in those veterans with CHC contribute to impaired PCS but not MCS. Anti-HCV(+) status negatively affects HRQoL, particularly MCS, independently of medical and psychiatric co-morbidities.

vorige artikel Health-related quality-of-life measures for long-term follow-up in children after major trauma

volgende artikel The use of focus groups in the development of the PROMIS pediatrics item bank

Armstrong, G. L., Wasley, A., Simard, E. P., McQuillan, G. M., Kuhnert, W. L., & Alter M. J. (2006). The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Annals of Internal Medicine, 144, 705–714.PubMed

Alter, M. J., Mast, E. E., Moyer, L. A, & Margolis, H. S. (1998). Hepatitis C. Infectious Disease Clinics of North America, 12, 13–26.PubMedCrossRef

Foster, G. R., Goldin, R. D., & Thomas, H. C. (1998). Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology, 27, 209–212.PubMedCrossRef

Davis, G. L., Balart, L. A., Schiff, E. R., et al. (1994). Assessing health-related quality of life in chronic hepatitis C using the sickness impact profile. Clinical Therapeutics, 16, 334–343 (discussion 271–272).

Ware, J. E., Jr., Bayliss, M. S., Mannocchia, M., et al. (1999). Health-related quality of life in chronic hepatitis C: impact of disease and treatment response. The interventional therapy group. Hepatology, 30, 550–555.PubMedCrossRef

Bonkovsky, H. L., & Woolley, J. M. (1999). Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy.The Consensus Interferon Study Group. Hepatology, 29, 264–270.PubMedCrossRef

Fontana, R. J., Moyer, C. A., Sonnad, S., et al. (2001). Comorbidities and quality of life in patients with interferon-refractory chronic hepatitis C. The American Journal of Gastroenterology, 96, 170–178.PubMedCrossRef

Chong, C. A., Gulamhussein, A., Heathcote, E. J., et al. (2003). Health-state utilities and quality of life in hepatitis C patients. The American Journal of Gastroenterology, 98, 630–638.PubMedCrossRef

Miller , E. R., Hiller, J. E., & Shaw, D. R. (2001). Quality of life in HCV-infection: Lack of association with ALT levels. Australian and New Zealand Journal of Public Health, 25, 355–361.PubMedCrossRef

10.

Schwarzinger, M., Dewedar, S., Rekacewicz, C., et al. (2004). Chronic hepatitis C virus infection: Does it really impact health-related quality of life? A study in rural Egypt. Hepatology, 40, 1434–1441.PubMedCrossRef

11.

Obhrai, J., Hall, Y., & Anand, B. S. (2001). Assessment of fatigue and psychologic disturbances in patients with hepatitis C virus infection. Journal of Clinical Gastroenterology, 32, 413–417.PubMedCrossRef

12.

Yates, W. R., & Gleason, O. (1998). Hepatitis C and depression. Depress Anxiety, 7, 188–193.PubMedCrossRef

13.

Lim, J. K., Cronkite, R., Goldstein, M. K., & Cheung, R. C. (2006). The impact of chronic hepatitis C and comorbid psychiatric illnesses on health-related quality of life. Journal of Clinical Gastroenterology, 40, 528–534.PubMedCrossRef

14.

Hussain, K. B., Fontana, R. J., Moyer, C. A., Su, G. L., Sneed-Pee, N., & Lok, A. S. (2001). Comorbid illness is an important determinant of health-related quality of life in patients with chronic hepatitis C. The American Journal of Gastroenterology, 96, 2737–2744.PubMedCrossRef

15.

Desai, R. A., Rosenheck, R. A., & Agnello, V. (2003). Prevalence of Hepatitis C virus infection in a sample of homeless veterans. Social Psychiatry and Psychiatric Epidemiology, 38, 396–401.PubMed

16.

Roselle, G. A., Danko, L. H., Kralovic, S. M., Simbartl, L. A., & Kizer, K. W. (2002). National hepatitis C surveillance day in the Veterans health administration of the department of Veterans affairs. Military Medicine, 167, 756–759.PubMed

17.

Cheung, R. C. (2000). Epidemiology of hepatitis C virus infection in American veterans. The American Journal of Gastroenterology, 95, 740–747.PubMedCrossRef

18.

Kizer, K.W. (2000). Re-engineering the Veterans health care system. In P. Ramsaroop, M. Ball, D. Beaulieuu, et al. (Eds.). Advancing federal sector health care (pp. 79–96). New York: Springer Verlag.

19.

Randall, M., Kilpatrick, K. E., Pendergast, J. F., Jones, K. R., & Vogel, W. B. (1987). Differences in patient characteristics between Veterans Administration and community hospitals. Implications for VA planning. Medical Care, 25, 1099–1104.PubMedCrossRef

20.

Moore, D., Feurer, I., Speroff, T., et al. (2003). Survival and quality of life after organ transplantation in veterans and nonveterans. American Journal of Surgery, 186, 476–480.PubMedCrossRef

21.

Kazis, L. E., Miller, D. R., Clark, J., et al. (1998). Health-related quality of life in patients served by the Department of Veterans Affairs: Results from the Veterans Health Study. Archives of Internal Medicine, 158, 626–632.PubMedCrossRef

22.

Gilsen, R., Hoeymans, N., Schellevis, F. G., et al. (2001). Causes and consequences of comorbidity : A review. Journal of Clinical Epidemiology, 54, 661–674.CrossRef

23.

Fortin, M., Lapointe, L., Hudon, C., et al. (2004) Multimorbidity and quality of life in primary care : A systemic review. Health and quality of life outcomes, 2, 51.

24.

Selim, A. J., Berlowitz, D. R., Fincke, G., et al. (2004). The health status of elderly veteran enrollees in the Veterans Health Administration. Journal of the American Geriatrics Society, 52, 1271–1276.PubMedCrossRef

25.

Kazis , L. E. (2000). The Veterans SF36 health status questionnaire: development and application in the Veterans Health Administration. Medical Outcomes Trust Monitor, 5, 1–2.

26.

Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473–483.PubMedCrossRef

27.

Ware, J. E., Kosinsky, M., & Keller, S. D. (1994). Physical and mental health summary scales: A users manual. Nosto, MA: The Health Institute, New England Medical Center.

28.

Kazis, L. E., Skinner, K., Rogers, W., et al. (1998). Health status and outcomes of veterans: physical and mental component summary scores (SF-36V). National Survey of Ambulatory Care Patients, Mid-year Executive Report. Washington D.C.: Department of Veteran Affairs, Veterans Health Administration, Office of Quality and Performance.

29.

Chow, G. C (1960) Tests of Equality Between Sets of Coefficients in Two Linear Regressions. Econometrica, 28, 591–605.CrossRef

30.

Olson, S. H., Iyer, S., Scott, J., et al. (2005). Cancer history and other personal factors affect quality of life in patients with hepatitis C. Health and Quality of Life Outcomes, 3, 39.PubMedCrossRef

31.

Rodger, A. J., Jolley, D., Thompson, S. C., Lanigan, A., & Crofts, N. (1999) The impact of diagnosis of hepatitis C virus on quality of life. Hepatology, 30, 1299–1301.PubMedCrossRef

32.

Zacks, S., Beavers, K., Theodore, D., et al. (2006). Social stigmatization and hepatitis C virus infection. Journal of Clinical Gastroenterology, 40, 220–224.PubMedCrossRef

33.

Briggs, M. E., Baker, C., Hall, R., et al. (2001). Prevalence and risk factors for hepatitis C virus infection at an urban Veterans Administration medical center. Hepatology, 34, 1200–1205.PubMedCrossRef

34.

el-Serag, H. B., Kunik, M., Richardson, P., & Rabeneck, L. (2002). Psychiatric disorders among veterans with hepatitis C infection. Gastroenterology, 123, 476–482.PubMedCrossRef

35.

McHorney , C. A., Haley, S. M., & Ware, J. E. (1997). Evaluation of the MOS SF-36 Physical Functioning Scale (PF-10): II. Comparison of relative precision using Likert and Rasch scoring methods. Journal of Clinical Epidemiology, 50, 451–461.PubMedCrossRef

36.

Hobart , J. C., Cano, S. J., Zajicek J. P., & Thompson, A. J. (2007). Rating scales as outcome measures for clinical trials in neurology: Problems, solutions, and recommendations. Lancet Neurology, 6, 1094–1105.PubMedCrossRef

37.

Raczek, A. E., Ware, J. E., Bjorner, J. B., Gandek, B., et al. (1998) Comparison of Rasch and summated rating scales constructed from SF-36 physical functioning items in seven countries: Results from the IQOLA Project. International Quality of Life Assessment. Journal of Clinical Epidemiology, 51, 1203–1214.PubMedCrossRef

38.

Ware, J. E., Bjorner, J., & Kosinski, M. (2000) Practical implications of item response theory and computerized adaptive testing: A brief summary of ongoing studies of widely used headache impact scales. Medical Care, 38[Suppl 9], II73–II82.

39.

Wolinsky, F. D., Coe, R. M., Mosely, R. R., 2nd, et al. (1985). Veterans’ and nonveterans’ use of health services. A comparative analysis. Medical Care, 23, 1358–1371.

40.

von Wagner, M., Lee, J. H., Kronenberger, B., Friedl, R., Sarrazin, C., et al. (2006). Impaired health-related quality of life in patients with chronic hepatitis C and persistently normal aminotransferase levels. Journal of Viral Hepatitis, 13, 828–834.CrossRef

41.

Butt, A. A., Justice, A. C., Skanderson, M., Rigsby, M. O., Good, C. B., & Kwoh, C. K. (2007). Rate and predictors of treatment prescription for hepatitis C. Gut, 56, 385–389.PubMedCrossRef

Titel: The impact of chronic hepatitis C and co-morbid illnesses on health-related quality of life
Auteurs: Jeffrey W. Kwan
Ruth C. Cronkite
Antony Yiu
Mary K. Goldstein
Lewis Kazis
Ramsey C. Cheung
Publicatiedatum: 01-06-2008
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 5/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-008-9344-3

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Objectives

Methods

Results

Conclusions

Log in om toegang te krijgen

Andere artikelen Uitgave 5/2008

The use of focus groups in the development of the PROMIS pediatrics item bank

Quality of life valuations of mammography screening

An empirical comparison of the WHOQOL-BREF and the SGRQ among patients with COPD

Symptoms, supportive care needs, and function in cancer patients: how are they related?

Quality of life in cancer patients in South Asia: psychometric properties of the Sinhala version of the EORTC QLQ-C30 in cancer patients with heterogeneous diagnoses

PedsQL relates to function and behavior in very low and normal birth weight 2- and 3-year-olds from a regional cohort