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20-06-2016 | Review

The health-related quality of life of ankylosing spondylitis patients assessed by SF-36: a systematic review and meta-analysis

Auteurs: Xiao Yang, Dazhi Fan, Qing Xia, Mengmeng Wang, Xu Zhang, Xiaona Li, Guoqi Cai, Li Wang, Lihong Xin, Shengqian Xu, Faming Pan

Gepubliceerd in: Quality of Life Research | Uitgave 11/2016

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Abstract

Purpose

The main purpose of this meta-analysis was to evaluate the impact of ankylosing spondylitis on the health-related quality of life assessed by the Medical Outcomes Short-Form-36 questionnaire (SF-36).

Methods

A systematic literature search was performed on PubMed and Web of Science until January 22, 2016 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. The radar chart was used to compare the scores of AS patients with other health conditions. Spearman’s correlation analysis and meta-regression were used to explore the related factors. STATA (version 11.0) and SPSS (version 13.0) were adopted in this meta-analysis.

Results

Thirty-eight studies were included in this study, which were all reliable to summarize the scores of the SF-36. Pooled mean scores of the physical health domains ranged from 45.93 to 58.17, with the RP and PF domains being the lowest and the highest, respectively. Pooled mean scores of the mental health domains ranged from 47.49 to 62.52, with the VT and SF domains being the lowest and the highest, respectively. Besides, the physical component summary was lower than the mental component summary. BASDAI and BASFI were negatively associated with some domains of the SF-36 significantly. Patients with AS had a substantial impaired HRQoL in comparison with the general population.

Conclusions

AS could adversely affect the HRQoL of patients. Measuring HRQoL should be considered as an essential part of the overall assessment of health status of AS patients, which would provide valuable clues for improving the management of disease and making decisions regarding treatment.
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Metagegevens
Titel
The health-related quality of life of ankylosing spondylitis patients assessed by SF-36: a systematic review and meta-analysis
Auteurs
Xiao Yang
Dazhi Fan
Qing Xia
Mengmeng Wang
Xu Zhang
Xiaona Li
Guoqi Cai
Li Wang
Lihong Xin
Shengqian Xu
Faming Pan
Publicatiedatum
20-06-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 11/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1345-z