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20-06-2016 | Review | Uitgave 11/2016

Quality of Life Research 11/2016

The health-related quality of life of ankylosing spondylitis patients assessed by SF-36: a systematic review and meta-analysis

Quality of Life Research > Uitgave 11/2016
Xiao Yang, Dazhi Fan, Qing Xia, Mengmeng Wang, Xu Zhang, Xiaona Li, Guoqi Cai, Li Wang, Lihong Xin, Shengqian Xu, Faming Pan
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s11136-016-1345-z) contains supplementary material, which is available to authorized users.
Xiao Yang and Dazhi Fan contributed equally to this work and should be considered co-first authors.



The main purpose of this meta-analysis was to evaluate the impact of ankylosing spondylitis on the health-related quality of life assessed by the Medical Outcomes Short-Form-36 questionnaire (SF-36).


A systematic literature search was performed on PubMed and Web of Science until January 22, 2016 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. The radar chart was used to compare the scores of AS patients with other health conditions. Spearman’s correlation analysis and meta-regression were used to explore the related factors. STATA (version 11.0) and SPSS (version 13.0) were adopted in this meta-analysis.


Thirty-eight studies were included in this study, which were all reliable to summarize the scores of the SF-36. Pooled mean scores of the physical health domains ranged from 45.93 to 58.17, with the RP and PF domains being the lowest and the highest, respectively. Pooled mean scores of the mental health domains ranged from 47.49 to 62.52, with the VT and SF domains being the lowest and the highest, respectively. Besides, the physical component summary was lower than the mental component summary. BASDAI and BASFI were negatively associated with some domains of the SF-36 significantly. Patients with AS had a substantial impaired HRQoL in comparison with the general population.


AS could adversely affect the HRQoL of patients. Measuring HRQoL should be considered as an essential part of the overall assessment of health status of AS patients, which would provide valuable clues for improving the management of disease and making decisions regarding treatment.

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