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05-09-2015 | Original Paper | Uitgave 1/2016

The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 1/2016

Auteurs:: Susan L. Hyman, Patricia A. Stewart, Jennifer Foley, Usa Cain, Robin Peck, Danielle D. Morris, Hongyue Wang, Tristram Smith

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Abstract

To obtain information on the safety and efficacy of the gluten-free/casein-free (GFCF) diet, we placed 14 children with autism, age 3–5 years, on the diet for 4–6 weeks and then conducted a double-blind, placebo-controlled challenge study for 12 weeks while continuing the diet, with a 12-week follow-up. Dietary challenges were delivered via weekly snacks that contained gluten, casein, gluten and casein, or placebo. With nutritional counseling, the diet was safe and well-tolerated. However, dietary challenges did not have statistically significant effects on measures of physiologic functioning, behavior problems, or autism symptoms. Although these findings must be interpreted with caution because of the small sample size, the study does not provide evidence to support general use of the GFCF diet.

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Titel: The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with Autism
Auteurs:: Susan L. Hyman
Patricia A. Stewart
Jennifer Foley
Usa Cain
Robin Peck
Danielle D. Morris
Hongyue Wang
Tristram Smith
Publicatiedatum: 05-09-2015
DOI: https://doi.org/10.1007/s10803-015-2564-9
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 1/2016
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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