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The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children.
Generation R is a population-based prospective cohort study from fetal life onwards in Rotterdam, The Netherlands. Children were born in 2002–2006. Blood from mothers and placenta cord blood were sampled. Mothers’ HRQOL was measured 5 times during pregnancy and after birth using SF-12 and EQ-5D. Children’s HRQOL was measured 5 times between age 1 and 5/6 years using Infant-Toddler Quality Of Life questionnaire (ITQOL), Health Status Classification System PreSchool (HSCS-PS) and Child Health Questionnaire Parent Form 28 items (CHQ-PF28), respectively.
DNA is available for 8,055 mothers and 5,908 children. Genotyping of various candidate genes and a genome-wide association (GWA) scan (Illumina 610K) of child DNA were done. A template for gene-HRQOL analyses is provided. We start with candidate gene study on HRQOL of mothers and children. Gene–environment interaction and interaction with medical indicators of health status will be explored. Next, GWA study on HRQOL will be performed.
Gaining insight into the determinants of HRQOL is essential to assisting efforts in health policy and clinical application to improve well-being and health. In the future, it might be possible to complement HRQOL assessments by examinations of genetic markers. Strengths and weaknesses of the Generation R study are discussed.
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The WHOQOL Group. (1994). Development of the WHOQOL: Rationale and current status. International Journal of Mental Health, 23(3), 24–56.
Eiser, C., & Morse, R. (2001). Quality-of-life measures in chronic diseases of childhood. Health Technology Assessment, 5(4), 1–157. PubMed
Raat, H., Botterweck, A. M., Landgraf, J. M., Hoogeveen, W. C., & Essink-Bot, M. L. (2005). Reliability and validity of the short form of the child health questionnaire for parents (CHQ-PF28) in large random school based and general population samples. Journal of Epidemiology and Community Health, 59(1), 75–82. CrossRefPubMed
Mangunkusumo, R. M. (2006). E-health4Uth, Integrating monitoring and prevention in youth health care. Thesis Erasmus MC, University Medical Center Rotterdam.
Oostenbrink, R., Spong, K., de Goede-Bolder, A., Landgraf, J. M., Raat, H., & Moll, H. A. (2007). Parental reports of health-related quality of life in young children with eurofibromatosis type 1: Influence of condition specific determinants. Journal of Pediatrics, 151(2), 182–1866. 6 e1-2. CrossRefPubMed
Buysse, C. P. M., Raat, H., Hazelzet, J. A., Hop, W. C. J., Maliepaard, M., & Joosten, K. F. M. (2008). Surviving meningococcal septic shock: health consequences and quality of life in children and their parents up to 2 years after PICU discharge. Critical Care Medicine, 36(2), 596–602. CrossRefPubMed
Prince, F. H. M., Geerdink, L. M., Borsboom, G. J. J. M., Twilt, M., van Rossum, M. A. J., Hoppenreijs, E. P. A. H., et al. (2009). Major improvements in health-related quality of life during the use of etanercept in patients with previously refractory juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69, 138–142. CrossRef
von Rueden, U., Gosch, A., Rajmil, L., Bisegger, C., & Ravens-Sieberer, U. (2006). Socioeconomic determinants of health related quality of life in childhood and adolescence: results from a European study. Journal of Epidemiology and Community Health, 60(2), 130–135. CrossRef
Center for research and statistics, Rotterdam (COS); http://www.cos.rotterdam.nl; 2005.
Essink-Bot, M. L., Krabbe, P. F., Bonsel, G. J., & Aaronson, N. K. (1997). An empirical comparison of four generic health status measures. The nottingham health profile, the medical outcomes study 36-item short-form health survey, the COOP/WONCA charts, and the EuroQol instrument. Medical Care, 35(5), 522–537. CrossRefPubMed
Ware, J. E., Gandek, B., Kosinski, M., Aaronson, N. K., Apolone, G., Brazier, J., et al. (1998). The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithms in 10 countries: Results from the IQOLA Project. International quality of life assessment. Journal of Clinical Epidemiology, 51(11), 1167–1170. CrossRefPubMed
Landgraf, J. M. (1994). The infant-toddler child health questionnaire: Conceptual framework, logic content, and preliminary psychometric results. Boston: Health Act.
Nathan, P. C., Furlong, W., DePauw, S., Horsman, J., van Schaik, C., Rolland, M., et al. (2004). Health status of young children during various phases of therapy for advanced neuroblastoma. Pediatric Blood & Cancer, 43(6), 659–667. CrossRef
Synnes, A. R., Lefebvre, F., & Cake, H. A. (2006). Current status of neonatal follow-up in Canada. Paediatr Child Health, 11(5), 271–274. PubMed
Landgraf, J. M., Abetz, L., & Ware, J. E. (1996). The CHQ user’s manual. Boston: The Health Institute, New England Medical Center.
Gorelick, M. H., Scribano, P. V., Stevens, M. W., & Schultz, T. R. (2003). Construct validity and responsiveness of the child health questionnaire in children with acute asthma. Annals of Allergy, Asthma & Immunology, 90(6), 622–628. CrossRef
Ruperto, N., Ravelli, A., Pistorio, A., Malattia, C., Cavuto, S., Gado-West, L., et al. (2001). Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodology. Clinical and Experimental Rheumatology, 4 Suppl 23(23), S1–S9.
Goldstein, H. (1995). Multilevel statistical models (2nd ed.). London: Edward Arnold.
Sprangers, M. A. G., et al. (2010). Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes. Quality of Life Research. doi: 10.1007/s11136-010-9759-5.
Panepinto, J. A., O’Mahar, K. M., DeBaun, M. R., Loberiza, F. R., & Scott, J. P. (2005). Health-related quality of life in children with sickle cell disease: Child and parent perception. British Journal Haematology, 130(3), 437–444. CrossRef
- The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children
Lenie van Rossem
Vincent W. V. Jaddoe
Jeanne M. Landgraf
Henriëtte A. Moll
Johan P. Mackenbach
- Springer Netherlands