Top

Gepubliceerd in:

01-12-2010

The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children

Auteurs: Hein Raat, Lenie van Rossem, Vincent W. V. Jaddoe, Jeanne M. Landgraf, David Feeny, Henriëtte A. Moll, Albert Hofman, Johan P. Mackenbach

Gepubliceerd in: Quality of Life Research | Uitgave 10/2010

Abstract

Aim

The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children.

Methods

Generation R is a population-based prospective cohort study from fetal life onwards in Rotterdam, The Netherlands. Children were born in 2002–2006. Blood from mothers and placenta cord blood were sampled. Mothers’ HRQOL was measured 5 times during pregnancy and after birth using SF-12 and EQ-5D. Children’s HRQOL was measured 5 times between age 1 and 5/6 years using Infant-Toddler Quality Of Life questionnaire (ITQOL), Health Status Classification System PreSchool (HSCS-PS) and Child Health Questionnaire Parent Form 28 items (CHQ-PF28), respectively.

Results

DNA is available for 8,055 mothers and 5,908 children. Genotyping of various candidate genes and a genome-wide association (GWA) scan (Illumina 610K) of child DNA were done. A template for gene-HRQOL analyses is provided. We start with candidate gene study on HRQOL of mothers and children. Gene–environment interaction and interaction with medical indicators of health status will be explored. Next, GWA study on HRQOL will be performed.

Conclusions

Gaining insight into the determinants of HRQOL is essential to assisting efforts in health policy and clinical application to improve well-being and health. In the future, it might be possible to complement HRQOL assessments by examinations of genetic markers. Strengths and weaknesses of the Generation R study are discussed.

vorige artikel Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states

volgende artikel Effects of integrated yoga on quality of life and interpersonal relationship of pregnant women

The WHOQOL Group. (1994). Development of the WHOQOL: Rationale and current status. International Journal of Mental Health, 23(3), 24–56.

Connolly, M. A., & Johnson, J. A. (1999). Measuring quality of life in paediatric patients. Pharmacoeconomics, 16(6), 605–625.CrossRefPubMed

Eiser, C., & Morse, R. (2001). Quality-of-life measures in chronic diseases of childhood. Health Technology Assessment, 5(4), 1–157.PubMed

Raat, H., Mohangoo, A. D., & Grootenhuis, M. A. (2006). Pediatric health-related quality of life questionnaires in clinical trials. Current opinion in Allergy and Clinical Immunology, 6(3), 180–185.CrossRefPubMed

Raat, H., Botterweck, A. M., Landgraf, J. M., Hoogeveen, W. C., & Essink-Bot, M. L. (2005). Reliability and validity of the short form of the child health questionnaire for parents (CHQ-PF28) in large random school based and general population samples. Journal of Epidemiology and Community Health, 59(1), 75–82.CrossRefPubMed

Mangunkusumo, R. M. (2006). E-health4Uth, Integrating monitoring and prevention in youth health care. Thesis Erasmus MC, University Medical Center Rotterdam.

Bruijn, J., Arts, W. F., Duivenvoorden, H., Dijkstra, N., Raat, H., & Passchier, J. (2009). Quality of life in children with primary headache in a general hospital. Cephalalgia,. doi:10.1111/j1468-29822008.01774x.PubMed

Peetsold, M. G., Hofman, V. E., Huisman, J., Heij, H. A., Raat, H., & Gemke, R. J. B. J. (2009). Psychological outcome and health-related quality of life in children 6–18 years old born with a congenital diaphragmatic hernia. Archives of Disease in Childhood, 94, 834–840.CrossRefPubMed

Mohangoo, A. D., de Koning, H. J., Mangunkusumo, R. T., & Raat, H. (2007). Health-related quality of life in adolescents with wheezing attacks. Journal of Adolescent Health, 41(5), 464–471.CrossRefPubMed

10.

Oostenbrink, R., Spong, K., de Goede-Bolder, A., Landgraf, J. M., Raat, H., & Moll, H. A. (2007). Parental reports of health-related quality of life in young children with eurofibromatosis type 1: Influence of condition specific determinants. Journal of Pediatrics, 151(2), 182–1866. 6 e1-2.CrossRefPubMed

11.

Bannink, E. M. N., Raat, H., Mulder, P. G. H., & Muinck Keizer-Schrama, S. M. P. F. (2006). Quality of life after growth hormone therapy and induced puberty in women with turner syndrome. Journal of Pediatrics, 148(1), 95–101.CrossRefPubMed

12.

Buysse, C. P. M., Raat, H., Hazelzet, J. A., Hop, W. C. J., Maliepaard, M., & Joosten, K. F. M. (2008). Surviving meningococcal septic shock: health consequences and quality of life in children and their parents up to 2 years after PICU discharge. Critical Care Medicine, 36(2), 596–602.CrossRefPubMed

13.

Prince, F. H. M., Geerdink, L. M., Borsboom, G. J. J. M., Twilt, M., van Rossum, M. A. J., Hoppenreijs, E. P. A. H., et al. (2009). Major improvements in health-related quality of life during the use of etanercept in patients with previously refractory juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69, 138–142.CrossRef

14.

von Rueden, U., Gosch, A., Rajmil, L., Bisegger, C., & Ravens-Sieberer, U. (2006). Socioeconomic determinants of health related quality of life in childhood and adolescence: results from a European study. Journal of Epidemiology and Community Health, 60(2), 130–135.CrossRef

15.

Sprangers, M. A. G., Sloan, J. A., Veenhoven, R., et al. (2009). The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes. Twin Research and Human Genetics, 12(3), 301–311.CrossRefPubMed

16.

López-León, S., Janssens, A. C. J. W., Gonzalez-Zuloeta Ladd, A. M., Del-Favoro, J., Claes, S. J., Oostra, B. A., et al. (2008). Meta-analyses of genetic studies on major depressive disorder. Molecular Psychiatry, 13, 772–785.CrossRefPubMed

17.

Singh, R., Kølvraa, S., Bross, P., Gregersen, N., Andersen Nexø, B., Frederiksen, H., et al. (2004). Association between low self-rated health and heterozygosity for–110A > C polymorphism in the promoter region of HSP70–1 in aged Danish twins. Biogerontology, 5, 169–176.CrossRefPubMed

18.

Kim, H., Ramsay, E., Lee, H., Wahl, S., & Dionne, R. A. (2009). Genome-wide association study of acute postsurgical pain in humans. Pharmacogenomics, 10, 171–179.CrossRefPubMed

19.

Collado-Hidalgo, A., Bower, J. E., Ganz, P. A., Irwin, M. R., & Cole, S. W. (2008). Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings. Brain, Behavior, and Immunity, 22, 1197–1200.CrossRefPubMed

20.

Jaddoe, V. W. V., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Verhulst, F. C., et al. (2006). The generation R study: Design and cohort profile. European Journal of Epidemiology, 21, 475–484.CrossRefPubMed

21.

Jaddoe, V. W., Bakker, R., van Duijn, C. M., et al. (2007). The generation R study biobank: A resource for epidemiological studies in children and their parents. European Journal of Epidemiology, 22(12), 917–923.CrossRefPubMed

22.

Jaddoe, V. W., van Duijn, C. M., van der Heijden, A. J., et al. (2008). The generation R study: Design and cohort update until the age of 4 years. European Journal of Epidemiology, 23(12), 801–811.CrossRefPubMed

23.

Center for research and statistics, Rotterdam (COS); http://www.cos.rotterdam.nl; 2005.

24.

Essink-Bot, M. L., Krabbe, P. F., Bonsel, G. J., & Aaronson, N. K. (1997). An empirical comparison of four generic health status measures. The nottingham health profile, the medical outcomes study 36-item short-form health survey, the COOP/WONCA charts, and the EuroQol instrument. Medical Care, 35(5), 522–537.CrossRefPubMed

25.

Ware, J. E., Keller, S. D., Gandek, B., Brazier, J. E., & Sullivan, M. (1995). Evaluating translations of health status questionnaires. Methods from the IQOLA project. International quality of life assessment. Int J Technol Assess Health Care, 11(3), 525–551.CrossRefPubMed

26.

Ware, J. E., Gandek, B., Kosinski, M., Aaronson, N. K., Apolone, G., Brazier, J., et al. (1998). The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithms in 10 countries: Results from the IQOLA Project. International quality of life assessment. Journal of Clinical Epidemiology, 51(11), 1167–1170.CrossRefPubMed

27.

Ware, J. E., Kosinski, M., & Keller, S. D. (1996). A 12-Item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 34(3), 220–233.CrossRefPubMed

28.

Johnson, J. A., & Coons, S. J. (1998). Comparison of the EQ-5D and SF-12 in an adult US sample. Quality of Life Research, 7, 155–166.CrossRefPubMed

29.

Raat, H., Bonsel, G. J., Hoogeveen, W. C., & Essink-Bot, M. L. (2004). Feasibility and reliability of a mailed questionnaire to obtain visual analogue scale valuations for health states defined by the Health Utilities Index Mark 3. Medical Care, 42(1), 13–18.CrossRefPubMed

30.

Fryback, D. G., Cross Dunham, N., Palta, M., Hanmer, J., Buechner, J., Cherepanov, D., et al. (2007). US norms for six generic health-related quality of life indexes from the national health measurement study. Medical Care, 45(12), 1162–1170.CrossRefPubMed

31.

Johnson, J. A., Jeffrey, A., & Maddigan, S. L. (2004). Performance of the RAND-12 and SF- 12 Summary Scores in Type-2 Diabetes. Quality of Life Research, 13(2), 449–456.CrossRefPubMed

32.

Landgraf, J. M. (1994). The infant-toddler child health questionnaire: Conceptual framework, logic content, and preliminary psychometric results. Boston: Health Act.

33.

Raat, H., Landgraf, J. M., Oostenbrink, R., Moll, H. A., & Essink-Bot, M. L. (2007). Reliability and validity of the Infant and Toddler Quality of Life Questionnaire (ITQOL) in a general population and respiratory disease sample. Quality of Life Research, 16(3), 445–460.CrossRefPubMed

34.

Klassen, A. F., Landgraf, J. M., Lee, S. K., Barer, M., Raina, P., Chan, H. W., et al. (2003). Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire. Health Qual Life Outcomes, 1, 81.CrossRefPubMed

35.

Klassen, A. F., Lee, S. K., Raina, P., Chan, H. W., Matthew, D., & Brabyn, D. (2004). Health status and health-related quality of life in a population-based sample of neonatal intensive care unit graduates. Pediatrics, 113(3 Pt 1), 594–600.CrossRefPubMed

36.

Nathan, P. C., Furlong, W., DePauw, S., Horsman, J., van Schaik, C., Rolland, M., et al. (2004). Health status of young children during various phases of therapy for advanced neuroblastoma. Pediatric Blood & Cancer, 43(6), 659–667.CrossRef

37.

Saigal, S., Rosenbaum, P., Stoskopf, B., et al. (2005). Development, reliability and validity of a new measure of overall health for pre-school children. Quality of Life Research, 14, 243–257.CrossRefPubMed

38.

Synnes, A. R., Lefebvre, F., & Cake, H. A. (2006). Current status of neonatal follow-up in Canada. Paediatr Child Health, 11(5), 271–274.PubMed

39.

Guillemin, F., Bombardier, C., & Beaton, D. (1993). Cross-cultural adaptation of health- related quality of life measures: literature review and proposed guidelines. Journal of Clinical Epidemiology, 46(12), 1417–1432.CrossRefPubMed

40.

Landgraf, J. M., Abetz, L., & Ware, J. E. (1996). The CHQ user’s manual. Boston: The Health Institute, New England Medical Center.

41.

Gorelick, M. H., Scribano, P. V., Stevens, M. W., & Schultz, T. R. (2003). Construct validity and responsiveness of the child health questionnaire in children with acute asthma. Annals of Allergy, Asthma & Immunology, 90(6), 622–628.CrossRef

42.

Ruperto, N., Ravelli, A., Pistorio, A., Malattia, C., Cavuto, S., Gado-West, L., et al. (2001). Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodology. Clinical and Experimental Rheumatology, 4 Suppl 23(23), S1–S9.

43.

Goldstein, H. (1995). Multilevel statistical models (2nd ed.). London: Edward Arnold.

44.

Hirschhorn, J. N., & Daly, M. J. (2005). Genome-wide association studies for common diseases and complex traits. Nature reviews. Genetics, 6, 95–108.CrossRefPubMed

45.

Hofman, A., Breteler, M. M., van Duijn, C. M., Krestin, G. P., Pols, H. A., Stricker, B. H., et al. (2007). The rotterdam study: Objectives and design update. European Journal of Epidemiology, 22, 819–829.CrossRefPubMed

46.

Sprangers, M. A. G., et al. (2010). Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes. Quality of Life Research. doi:10.1007/s11136-010-9759-5.

47.

Lubetkin, E. I., Jia, H., Franks, P., & Gold, M. R. (2005). Relationship among sociodemographic factors, clinical conditions, and health-related quality of life: Examining the EQ-5D in the U.S. general population. Quality of Life Research, 14, 2187–2196.CrossRefPubMed

48.

Panepinto, J. A., O’Mahar, K. M., DeBaun, M. R., Loberiza, F. R., & Scott, J. P. (2005). Health-related quality of life in children with sickle cell disease: Child and parent perception. British Journal Haematology, 130(3), 437–444.CrossRef

49.

Houtzager, B. A., Grootenhuis, M. A., Caron, H. N., & Last, B. F. (2005). Sibling self-report, parental proxies, and quality of life: the importance of multiple informants for siblings of a critically ill child. Pediatric Hematology and Oncology, 22(1), 25–40.CrossRefPubMed

Titel: The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children
Auteurs: Hein Raat
Lenie van Rossem
Vincent W. V. Jaddoe
Jeanne M. Landgraf
David Feeny
Henriëtte A. Moll
Albert Hofman
Johan P. Mackenbach
Publicatiedatum: 01-12-2010
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 10/2010
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-010-9773-7

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Aim

Methods

Results

Conclusions

Log in om toegang te krijgen

Andere artikelen Uitgave 10/2010

Optimists doing something different: a patient’s view of geneQOL research

Daily activities mediate the relationship between personality and quality of life in middle-aged women

The relationship between chronic pain and health-related quality of life in long-term social assistance recipients in Norway

Effects of integrated yoga on quality of life and interpersonal relationship of pregnant women

New model to explain the EQ-5D VAS in patients who have undergone spinal fusion

Biological pathways and genetic variables involved in pain