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Gepubliceerd in: Quality of Life Research 2/2008

01-03-2008

The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study

Auteurs: Peter J. Lovrics, Sylvie D. Cornacchi, Francesco Barnabi, Tim Whelan, Charles H. Goldsmith

Gepubliceerd in: Quality of Life Research | Uitgave 2/2008

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Abstract

Background

The health utilities index (HUI3) is a health measurement instrument based on individuals’ preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC.

Methods

HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values.

Results

Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors.

Conclusion(s)

HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.
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Metagegevens
Titel
The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study
Auteurs
Peter J. Lovrics
Sylvie D. Cornacchi
Francesco Barnabi
Tim Whelan
Charles H. Goldsmith
Publicatiedatum
01-03-2008
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 2/2008
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-007-9305-2

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