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Department of Cardiology, VU Medical Centre, Amsterdam, the Netherlands
Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.)
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The effect of insulin on the heart
Part 2: Effects on function during and post myocardial ischaemia
L. J. Klein
F. C. Visser
- Bohn Stafleu van Loghum