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Quality of Life Research
Gepubliceerd in: Quality of Life Research 7/2009

01-09-2009

The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS

Auteurs: Bohdan Nosyk, Huiying Sun, Nick Bansback, Daphne P. Guh, Xin Li, Paul Barnett, Ahmed Bayoumi, Susan Griffin, Vilija Joyce, Mark Holodniy, Doug K. Owens, Aslam H. Anis

Gepubliceerd in: Quality of Life Research | Uitgave 7/2009

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Abstract

Objectives

To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.

Methods

Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.

Results

The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).

Conclusion

The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population.
vorige artikel Predicting EQ-5D utility scores from the 25-item National Eye Institute Vision Function Questionnaire (NEI-VFQ 25) in patients with age-related macular degeneration
volgende artikel Quality of life from the perspective of adolescents with cerebral palsy: “I just think I’m a normal kid, I just happen to have a disability”
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Metagegevens
Titel
The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS
Auteurs
Bohdan Nosyk
Huiying Sun
Nick Bansback
Daphne P. Guh
Xin Li
Paul Barnett
Ahmed Bayoumi
Susan Griffin
Vilija Joyce
Mark Holodniy
Doug K. Owens
Aslam H. Anis
Publicatiedatum
01-09-2009
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 7/2009
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-009-9504-0

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