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01-11-2009 | Uitgave 9/2009 Open Access

Quality of Life Research 9/2009

The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis

Tijdschrift:
Quality of Life Research > Uitgave 9/2009
Auteurs:
M. J. Harrison, L. M. Davies, N. J. Bansback, M. J. McCoy, S. M. M. Verstappen, K. Watson, D. P. M. Symmons, The British Society for Rheumatology Biologics Register Control Centre Consortium, on behalf of the BSRBR
Belangrijke opmerkingen
The members of the BSRBR Control Centre Consortium are detailed in the Appendix.

Abstract

Purpose

Comparative evidence regarding the responsiveness of the EQ-5D and SF-6D in arthritis patients is conflicting and insufficient across the range of disease severity. We examined the comparative responsiveness of the EQ-5D and SF-6D in cohorts of patients with early inflammatory disease through to severe rheumatoid arthritis (RA).

Methods

Responsiveness was tested using the effect size (ES) and standardised response mean (SRM). Correlation of change in EQ-5D and SF-6D with disease specific measures was tested using Pearson correlations and the Steiger’s Z test. Treatment response and self-reported change were used as anchors of important change.

Results

The EQ-5D was more responsive to deterioration (ES ratio (EQ-5D/SF-6D): 1.6–3.0) and the SF-6D more responsive to improvement (ES ratio (SF-6D/EQ-5D): 1.1–1.8) in health. The SF-6D did not respond well to deterioration in patients with established severe RA (ES and SRM 0.08). The EQ-5D provided larger absolute mean change estimates but with greater variance compared to the SF-6D.

Conclusions

The comparative responsiveness of the EQ-5D and SF-6D differs according to the direction of change. The level of mean change of the EQ-5D relative to the SF-6D has implications for cost-effectiveness analysis. Use of the SF-6D in patients with severe progressive disease may be inappropriate.

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