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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2014

01-02-2014 | Original Paper

The Clinical Utility of the Modified Checklist for Autism in Toddlers with High Risk 18–48 Month Old Children in Singapore

Auteurs: Hwan Cui Koh, Si Huan Lim, Gifford Jiguang Chan, Marisa Bilin Lin, Hong Huay Lim, Sylvia Henn Tean Choo, Iliana Magiati

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2014

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Abstract

The modified checklist for autism in toddlers (M-CHAT) is a tool developed for 16–30 month old children to screen for autism spectrum disorders (ASD). It is a well-researched tool, but little is known about its utility with Singaporean toddlers and with older children referred for developmental concerns. This study investigated the M-CHAT’s performance with 18–30 month old (N = 173) and >30–48 month old (N = 407) developmentally at-risk Singaporean children, when used with three recommended scoring methods i.e., the total, critical and Best7 scoring methods. The results indicate that the critical and Best7 scoring methods detected most true cases of ASD without inflating the false positive rates in toddlers, and that only the total scoring method performed acceptably for the older children.
Voetnoten
1
The psychometric properties of the M-CHAT were reported separately for each of the 3 scoring methods, instead of combined as in previous studies (i.e., failing either total or critical 6; and failing either total or Best 7). Combining the scoring methods was likely to increase sensitivity, but to decrease specificity, which was not desirable for screening a population already at risk of developmental issues. Further analyses only briefly reported here also indicated that values of sensitivity (Sn), specificity (Sp), PPV and NPV of using the combined scoring methods were very similar to those obtained from the total scoring method alone for both age groups, except that there was a slight increase in sensitivity for the scoring method of either total or Best 7 in the younger age group. For younger age group, either total or critical scoring method yielded Sn: 0.89, Sp: 0.58, PPV: 0.49, NPV: 0.92; either total or Best 7 scoring method yielded Sn: 0.93, Sp: 0.58, PPV: 0.50, NPV: 0.95. For the older age group, either total or critical 6 scoring method yielded Sn: 0.76, Sp: 0.71, PPV: 0.59, NPV: 0.84; and either total or Best 7 scoring method yielded Sn: 0.77, Sp: 0.71, PPV: 0.59, NPV: 0.85.
 
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Metagegevens
Titel
The Clinical Utility of the Modified Checklist for Autism in Toddlers with High Risk 18–48 Month Old Children in Singapore
Auteurs
Hwan Cui Koh
Si Huan Lim
Gifford Jiguang Chan
Marisa Bilin Lin
Hong Huay Lim
Sylvia Henn Tean Choo
Iliana Magiati
Publicatiedatum
01-02-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1880-1

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