Skip to main content
Top
Gepubliceerd in:

21-09-2018 | Empirical Research

The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene–Gene–Environment Study

Auteurs: Yanmiao Cao, Xiaonan Lin, Liang Chen, Linqin Ji, Wenxin Zhang

Gepubliceerd in: Journal of Youth and Adolescence | Uitgave 11/2018

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Behavioral genetics studies and new empirical evidence suggest that depression cannot simply be explained by the influence of single genes but that gene–gene–environment interactions are important to better understanding the etiology of depression. The present study investigated the main and interactive effects of COMT gene Val158Met polymorphism, DAT1 gene rs27072 polymorphism, and peer relationships (i.e., peer acceptance and rejection) on adolescent depressive symptoms. In a sample of 1045 Chinese Han adolescents (Mage = 12.34 ± 0.47 years, 50.1% girls), saliva samples, self-reported depressive symptoms and within-classroom peer nominations were collected. After controlling for gender, age, and SES, the three-way interaction of COMT, DAT1, and peer acceptance significantly concurrently predicted adolescent depressive symptoms. Adolescents with ValVal genotype of COMT and CC genotype of DAT1 were more sensitive to acceptance, compared to their counterparts carrying other combined genotypes. However, a similar three-way interaction was not significant in the case of peer rejection. Additionally, the split-half validation generally replicated these findings. More importantly, this study underscores complex polygenic underpinnings of depression and lends support for the gene–gene–environment interactions implicated in the etiology of depressive symptoms.
Literatuur
go back to reference Borenstein, M., Rothstein, D., & Cohen, D. (2005). Comprehensive meta-analysis: A computer program for research synthesis. Englewood, NJ: Biostat. Borenstein, M., Rothstein, D., & Cohen, D. (2005). Comprehensive meta-analysis: A computer program for research synthesis. Englewood, NJ: Biostat.
go back to reference Bukowski, W. M., Sippola, L., Hoza, B., & Newcomb, A. F. (2000). Pages from a sociometric notebook: An analysis of nomination and rating scale measures of acceptance, rejection, and social preference. New Directions for Child and Adolescent Development, 2000, 11–26. https://doi.org/10.1002/cd.23220008804.CrossRef Bukowski, W. M., Sippola, L., Hoza, B., & Newcomb, A. F. (2000). Pages from a sociometric notebook: An analysis of nomination and rating scale measures of acceptance, rejection, and social preference. New Directions for Child and Adolescent Development, 2000, 11–26. https://​doi.​org/​10.​1002/​cd.​23220008804.CrossRef
go back to reference Cao, C., Rijlaarsdam, J., van der Voort, A., Ji, L., Zhang, W., & Bakermans-Kranenburg, M. J. (2018). Associations between dopamine D2 receptor (DRD2) gene, maternal positive parenting and trajectories of depressive symptoms from early to mid-adolescence. Journal of Abnormal Child Psychology, 46, 365–379. https://doi.org/10.1007/s10802-017-0294-5.CrossRefPubMed Cao, C., Rijlaarsdam, J., van der Voort, A., Ji, L., Zhang, W., & Bakermans-Kranenburg, M. J. (2018). Associations between dopamine D2 receptor (DRD2) gene, maternal positive parenting and trajectories of depressive symptoms from early to mid-adolescence. Journal of Abnormal Child Psychology, 46, 365–379. https://​doi.​org/​10.​1007/​s10802-017-0294-5.CrossRefPubMed
go back to reference Carboni, E., Spielewoy, C., Vacca, C., Nosten-Bertrand, M., Giros, B., & Di Chiara, G. (2001). Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. Journal of Neuroscience, 21, 1–4.CrossRef Carboni, E., Spielewoy, C., Vacca, C., Nosten-Bertrand, M., Giros, B., & Di Chiara, G. (2001). Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. Journal of Neuroscience, 21, 1–4.CrossRef
go back to reference Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., ... Egan, M. F. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. The American Journal of Human Genetics, 75, 807–821. https://doi.org/10.1086/425589.CrossRefPubMed Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., ... Egan, M. F. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. The American Journal of Human Genetics, 75, 807–821. https://​doi.​org/​10.​1086/​425589.CrossRefPubMed
go back to reference Drabant, E. M., Hariri, A. R., Meyer-Lindenberg, A., Munoz, K. E., Mattay, V. S., Kolachana, B. S., ... Weinberger, D. R. (2006). Catechol O-methyltransferase Val158Met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry, 63, 1396–1406. https://doi.org/10.1001/archpsyc.63.12.1396. Drabant, E. M., Hariri, A. R., Meyer-Lindenberg, A., Munoz, K. E., Mattay, V. S., Kolachana, B. S., ... Weinberger, D. R. (2006). Catechol O-methyltransferase Val158Met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry, 63, 1396–1406. https://​doi.​org/​10.​1001/​archpsyc.​63.​12.​1396.
go back to reference Field, A. P. (2005). Intraclass correlation. In B. S. Everitt & D. C. Howell (Eds.), Encyclopedia of statistics in the behavioral sciences (pp. 1296–1305). Chichester, England: Wiley. Field, A. P. (2005). Intraclass correlation. In B. S. Everitt & D. C. Howell (Eds.), Encyclopedia of statistics in the behavioral sciences (pp. 1296–1305). Chichester, England: Wiley.
go back to reference Kovacs, M. (1992). Children’s Depression Inventory (CDI) manual. Toronto, Canada: Multi-Health Systems Inc. Kovacs, M. (1992). Children’s Depression Inventory (CDI) manual. Toronto, Canada: Multi-Health Systems Inc.
go back to reference Muthén, L., & Muthén, B. (1998). Mplus user’s guide. 6th ed. Los Angeles: Muthén & Muthén. 2010. Muthén, L., & Muthén, B. (1998). Mplus user’s guide. 6th ed. Los Angeles: Muthén & Muthén. 2010.
go back to reference Nelson, E., McClure, E., Parrish, J., Leibenluft, E., Ernst, M., Fox, N., & Pine, D. (2007). Brain systems underlying peer social acceptance in adolescents. Washington: Mood and Anxiety Disorders Program, National Institute of Mental Health 233–236. Unpublished manuscript. Nelson, E., McClure, E., Parrish, J., Leibenluft, E., Ernst, M., Fox, N., & Pine, D. (2007). Brain systems underlying peer social acceptance in adolescents. Washington: Mood and Anxiety Disorders Program, National Institute of Mental Health 233–236. Unpublished manuscript.
go back to reference Patterson, G. R., & Capaldi, D. M. (1990). A meditational model for boys’ depressed mood. In J. E. Rolf, A. Masten, D. Ciccheti, K. Neuchterlein & S. Weintraub (Eds.), Risk and protective factors in the development of psychopathology (pp. 141–163). Cambridge, UK: Cambridge University Press.CrossRef Patterson, G. R., & Capaldi, D. M. (1990). A meditational model for boys’ depressed mood. In J. E. Rolf, A. Masten, D. Ciccheti, K. Neuchterlein & S. Weintraub (Eds.), Risk and protective factors in the development of psychopathology (pp. 141–163). Cambridge, UK: Cambridge University Press.CrossRef
go back to reference Prata, D. P., Mechelli, A., Fu, C. H., Picchioni, M., Toulopoulou, T., Bramon, E., ... McGuire, P. (2009). Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences, 106, 13600–13605. https://doi.org/10.1073/pnas.0903007106.CrossRef Prata, D. P., Mechelli, A., Fu, C. H., Picchioni, M., Toulopoulou, T., Bramon, E., ... McGuire, P. (2009). Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences, 106, 13600–13605. https://​doi.​org/​10.​1073/​pnas.​0903007106.CrossRef
go back to reference Rommelse, N. N. J., Altink, M. E., Arias-V asquez, A., Buschgens, C. J. M., Fliers, E., Faraone, S. V., ... Oosterlaan, J. (2008). A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 1536–1546. https://doi.org/10.1002/ajmg.b.30848.CrossRef Rommelse, N. N. J., Altink, M. E., Arias-V asquez, A., Buschgens, C. J. M., Fliers, E., Faraone, S. V., ... Oosterlaan, J. (2008). A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 1536–1546. https://​doi.​org/​10.​1002/​ajmg.​b.​30848.CrossRef
go back to reference Sonuga-Barke, E. J., Oades, R. D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., ... Miranda, A. (2009). Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: The case of conduct and emotional problems in attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 50, 1052–1063. https://doi.org/10.1111/j.1469-7610.2009.02095.x.CrossRefPubMed Sonuga-Barke, E. J., Oades, R. D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., ... Miranda, A. (2009). Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: The case of conduct and emotional problems in attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 50, 1052–1063. https://​doi.​org/​10.​1111/​j.​1469-7610.​2009.​02095.​x.CrossRefPubMed
go back to reference Steinberg, L. (2014). Adolescence. 10th ed. New York, NY: McGraw-Hill. Steinberg, L. (2014). Adolescence. 10th ed. New York, NY: McGraw-Hill.
go back to reference Sulik, M. J., Eisenberg, N., Spinrad, T. L., Lemery-Chalfant, K., Swann, G., Silva, K. M., ... Verrelli, B. C. (2015). Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children’s internalizing symptoms and inhibitory control: Evidence for differential susceptibility. Development and Psychopathology, 27, 709–723. https://doi.org/10.1017/S0954579414000807.CrossRefPubMedPubMedCentral Sulik, M. J., Eisenberg, N., Spinrad, T. L., Lemery-Chalfant, K., Swann, G., Silva, K. M., ... Verrelli, B. C. (2015). Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children’s internalizing symptoms and inhibitory control: Evidence for differential susceptibility. Development and Psychopathology, 27, 709–723. https://​doi.​org/​10.​1017/​S095457941400080​7.CrossRefPubMedPubMedCentral
go back to reference Zhang, W. X., Cao, Y. M., Wang, M. P., Ji, L. Q., Chen, L., & Deater-Deckard, K. (2015). The dopamine D2 receptor Polymorphism (DRD2 TaqIA) interacts with maternal parenting in predicting early adolescent depressive symptoms: Evidence of differential susceptibility and age differences. Journal of Youth and Adolescence, 44, 1428–1440. https://doi.org/10.1007/s10964-015-0297-x.CrossRefPubMed Zhang, W. X., Cao, Y. M., Wang, M. P., Ji, L. Q., Chen, L., & Deater-Deckard, K. (2015). The dopamine D2 receptor Polymorphism (DRD2 TaqIA) interacts with maternal parenting in predicting early adolescent depressive symptoms: Evidence of differential susceptibility and age differences. Journal of Youth and Adolescence, 44, 1428–1440. https://​doi.​org/​10.​1007/​s10964-015-0297-x.CrossRefPubMed
go back to reference Zhang, W., Cao, C., Wang, M., Ji, L., & Cao, Y. (2016). Monoamine oxidase a (MAOA) and catechol-o-methyltransferase (COMT) gene polymorphisms interact with maternal parenting in association with adolescent reactive aggression but not proactive aggression: Evidence of differential susceptibility. Journal of Youth and adolescence, 45, 812–829. https://doi.org/10.1007/s10964-016-0442-1.CrossRefPubMed Zhang, W., Cao, C., Wang, M., Ji, L., & Cao, Y. (2016). Monoamine oxidase a (MAOA) and catechol-o-methyltransferase (COMT) gene polymorphisms interact with maternal parenting in association with adolescent reactive aggression but not proactive aggression: Evidence of differential susceptibility. Journal of Youth and adolescence, 45, 812–829. https://​doi.​org/​10.​1007/​s10964-016-0442-1.CrossRefPubMed
Metagegevens
Titel
The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms: A Gene–Gene–Environment Study
Auteurs
Yanmiao Cao
Xiaonan Lin
Liang Chen
Linqin Ji
Wenxin Zhang
Publicatiedatum
21-09-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Youth and Adolescence / Uitgave 11/2018
Print ISSN: 0047-2891
Elektronisch ISSN: 1573-6601
DOI
https://doi.org/10.1007/s10964-018-0925-3