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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2013

01-07-2013 | Original Paper

The Broader Autism Phenotype in Simplex and Multiplex Families

Auteurs: Jennifer A. Gerdts, Raphael Bernier, Geraldine Dawson, Annette Estes

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2013

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Abstract

Mothers, fathers, and siblings from 87 multiplex (M-mothers, M-fathers, and M-siblings) and 41 simplex (S-mothers, S-fathers, and S-siblings) Autism spectrum disorder families were assessed using the Broader Phenotype Autism Symptom Scale. S-mothers, S-fathers, and S-siblings showed more social interest and were more expressive in their use of nonverbal communication compared to M-mothers, M-fathers, and M-siblings. Conversational skills were also improved in S-fathers and S-siblings compared to M-fathers and M-siblings. S-siblings showed significantly lower rigidity and intense interests compared to M-siblings. The decreased number and intensity of broader autism phenotype traits observed in parents and siblings within simplex families provide behavioral evidence consistent with findings of increased de novo genetic events in simplex families.
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Metagegevens
Titel
The Broader Autism Phenotype in Simplex and Multiplex Families
Auteurs
Jennifer A. Gerdts
Raphael Bernier
Geraldine Dawson
Annette Estes
Publicatiedatum
01-07-2013
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2013
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1706-6

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