Skip to main content
Top
Gepubliceerd in: Quality of Life Research 6/2012

01-08-2012

The associations among coping, nadir CD4+ T-cell count, and non-HIV-related variables with health-related quality of life among an ambulatory HIV-positive patient population

Auteurs: Carl Armon, Kenneth Lichtenstein

Gepubliceerd in: Quality of Life Research | Uitgave 6/2012

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

We investigated HRQoL among HIV-positive outpatients from October, 2006-December, 2007, incorporating medical chart review, and a survey of coping styles.

Methods

Consented HIV-positive patients receiving medical care at University of Colorado Denver, with HAART as first antiretroviral regimen, completed the MOS-HIV and Brief COPE survey instruments. Linear regression identified a priori factors hypothesized to be associated with the MOS-HIV composite mental and physical health scores (MHS, PHS). Brief COPE survey maladaptive and adaptive coping components were added to the models and retained if significant.

Results

Among the 157 patient cohort, parsimonious multivariable linear regression models (P < 0.05) indicated higher nadir CD4+ T-cell counts and adaptive coping were associated with a higher MHS; public/no insurance, mental illness, current number of non-HIV medications, and maladaptive coping were inversely associated with MHS. Nadir CD4+ T-cell count and efavirenz use were associated with a higher PHS; mental illness, current number of non-HIV mediations, and maladaptive coping were inversely associated with PHS.

Conclusions

Factors independently associated with lower MHS and lower PHS include lower nadir CD4+ T-cell counts, and use of maladaptive coping. Efforts to reduce use of maladaptive coping strategies and earlier identification and treatment of HIV may improve HRQoL in HIV-positive patients.
Literatuur
3.
go back to reference Palella, F. J., Jr., Delaney, K. M., Moorman, A. C., et al. (1998). Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. New England Journal of Medicine, 338(13), 853–860.PubMedCrossRef Palella, F. J., Jr., Delaney, K. M., Moorman, A. C., et al. (1998). Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. New England Journal of Medicine, 338(13), 853–860.PubMedCrossRef
6.
go back to reference Burgoyne, R. W., Rourke, S. B., Behrens, D. M., & Salit, I. E. (2004). Long-term quality-of-life outcomes among adults living with HIV in the HAART era: The interplay of changes in clinical factors and symptom profile. AIDS and Behavior, 8(2), 151–163.PubMedCrossRef Burgoyne, R. W., Rourke, S. B., Behrens, D. M., & Salit, I. E. (2004). Long-term quality-of-life outcomes among adults living with HIV in the HAART era: The interplay of changes in clinical factors and symptom profile. AIDS and Behavior, 8(2), 151–163.PubMedCrossRef
7.
go back to reference Vidrine, D. J., Amick, B. C., I. I. I., Gritz, E. R., & Arduino, R. C. (2003). Functional status and overall quality of life in a multiethnic HIV-positive population. AIDS Patient Care & STDs, 17(4), 187–197.CrossRef Vidrine, D. J., Amick, B. C., I. I. I., Gritz, E. R., & Arduino, R. C. (2003). Functional status and overall quality of life in a multiethnic HIV-positive population. AIDS Patient Care & STDs, 17(4), 187–197.CrossRef
8.
go back to reference Preau, M., Vincent, E., Spire, B., et al. (2005). Health-related quality of life and health locus of control beliefs among HIV-infected treated patients. Journal of Psychosomatic Research, 59, 407–413.PubMedCrossRef Preau, M., Vincent, E., Spire, B., et al. (2005). Health-related quality of life and health locus of control beliefs among HIV-infected treated patients. Journal of Psychosomatic Research, 59, 407–413.PubMedCrossRef
9.
go back to reference Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: results from a multi-site interview project. Health & Quality of Life Outcomes, 1, 12.CrossRef Campsmith, M. L., Nakashima, A. K., & Davidson, A. J. (2003). Self-reported health-related quality of life in persons with HIV infection: results from a multi-site interview project. Health & Quality of Life Outcomes, 1, 12.CrossRef
10.
go back to reference Dougall, A. L., Smith, A. W., Somers, T. J., Posluszny, D. M., Rubinstein, W. S., & Baum, A. (2009). Coping with genetic testing for breast cancer susceptibility. Psychosomatic Medicine, 71(1), 98–105.PubMedCrossRef Dougall, A. L., Smith, A. W., Somers, T. J., Posluszny, D. M., Rubinstein, W. S., & Baum, A. (2009). Coping with genetic testing for breast cancer susceptibility. Psychosomatic Medicine, 71(1), 98–105.PubMedCrossRef
11.
go back to reference Fogel, J. (2004). Internet breast health information use and coping among women with breast cancer. Cyberpsychology & Behavior, 7(1), 59–63.CrossRef Fogel, J. (2004). Internet breast health information use and coping among women with breast cancer. Cyberpsychology & Behavior, 7(1), 59–63.CrossRef
12.
go back to reference Olley, B. O., Seedat, S., & Stein, D. J. (2006). Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: A 6-month follow-up study. Journal of Psychosomatic Research, 61(4), 479–484.PubMedCrossRef Olley, B. O., Seedat, S., & Stein, D. J. (2006). Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: A 6-month follow-up study. Journal of Psychosomatic Research, 61(4), 479–484.PubMedCrossRef
14.
go back to reference Mauskopf, J., Kitahata, M., Kauf, T., Richter, A., & Tolson, J. (2005). HIV antiretroviral treatment: Early versus later. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 39(5), 562–569.PubMed Mauskopf, J., Kitahata, M., Kauf, T., Richter, A., & Tolson, J. (2005). HIV antiretroviral treatment: Early versus later. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 39(5), 562–569.PubMed
15.
go back to reference Jia, H., Uphold, C. R., Wu, S., Chen, G. J., & Duncan, P. W. (2005). Predictors of changes in health-related quality of life among men with HIV infection in the HAART era. AIDS Patient Care & STDs, 19(6), 395–405.CrossRef Jia, H., Uphold, C. R., Wu, S., Chen, G. J., & Duncan, P. W. (2005). Predictors of changes in health-related quality of life among men with HIV infection in the HAART era. AIDS Patient Care & STDs, 19(6), 395–405.CrossRef
16.
go back to reference Carrieri, P., Spire, B., Duran, S., et al. (2003). Health-related quality of life after 1 year of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 32(1), 38–47.PubMedCrossRef Carrieri, P., Spire, B., Duran, S., et al. (2003). Health-related quality of life after 1 year of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 32(1), 38–47.PubMedCrossRef
17.
go back to reference Preau, M., Leport, C., Salmon-Ceron, D., et al. (2004). Health-related quality of life and patient-provider relationships in HIV-infected patients during the first 3 years after starting PI-containing antiretroviral treatment. AIDS Care, 16(5), 649–661.PubMedCrossRef Preau, M., Leport, C., Salmon-Ceron, D., et al. (2004). Health-related quality of life and patient-provider relationships in HIV-infected patients during the first 3 years after starting PI-containing antiretroviral treatment. AIDS Care, 16(5), 649–661.PubMedCrossRef
18.
go back to reference Preau, M., Protopopescu, C., Spire, B., et al. (2007). Health related quality of life among both current and former injection drug users who are HIV-infected. Drug and Alcohol Dependence, 86(2–3), 175–182.PubMedCrossRef Preau, M., Protopopescu, C., Spire, B., et al. (2007). Health related quality of life among both current and former injection drug users who are HIV-infected. Drug and Alcohol Dependence, 86(2–3), 175–182.PubMedCrossRef
19.
go back to reference Vosvick, M., Koopman, C., Gore-Felton, C., Thoresen, C., Krumboltz, J., & Spiegel, D. (2003). Relationship of functional quality of life to strategies for coping with the stress of living with HIV/AIDS. Psychosomatics, 44(1), 51–58.PubMedCrossRef Vosvick, M., Koopman, C., Gore-Felton, C., Thoresen, C., Krumboltz, J., & Spiegel, D. (2003). Relationship of functional quality of life to strategies for coping with the stress of living with HIV/AIDS. Psychosomatics, 44(1), 51–58.PubMedCrossRef
20.
go back to reference Jia, H., Uphold, C. R., Zheng, Y., et al. (2007). A further investigation of health-related quality of life over time among men with HIV infection in the HAART era. Quality of Life Research, 16, 961–968.PubMedCrossRef Jia, H., Uphold, C. R., Zheng, Y., et al. (2007). A further investigation of health-related quality of life over time among men with HIV infection in the HAART era. Quality of Life Research, 16, 961–968.PubMedCrossRef
21.
go back to reference Perez, J. E., Chartier, M., Koopman, C., Vosvick, M., Gore-Felton, C., & Spiegel, D. (2009). Spiritual striving, acceptance coping, and depressive symptoms among Adults living with HIV/AIDS. Journal of Health Psychology, 14(1), 88–97.PubMedCrossRef Perez, J. E., Chartier, M., Koopman, C., Vosvick, M., Gore-Felton, C., & Spiegel, D. (2009). Spiritual striving, acceptance coping, and depressive symptoms among Adults living with HIV/AIDS. Journal of Health Psychology, 14(1), 88–97.PubMedCrossRef
22.
go back to reference Maggiolo, F. (2009). Efavirenz: A decade of clinical experience in the treatment of HIV. Journal of Antimicrobial Chemotherapy, 64(5), 910–928.PubMedCrossRef Maggiolo, F. (2009). Efavirenz: A decade of clinical experience in the treatment of HIV. Journal of Antimicrobial Chemotherapy, 64(5), 910–928.PubMedCrossRef
23.
go back to reference Tozzi, V., Balestra, P., Galgani, S., et al. (2003). Neurocognitive performance and quality of life in patients with HIV infection. AIDS Research and Human Retroviruses, 19(8), 643–652.PubMedCrossRef Tozzi, V., Balestra, P., Galgani, S., et al. (2003). Neurocognitive performance and quality of life in patients with HIV infection. AIDS Research and Human Retroviruses, 19(8), 643–652.PubMedCrossRef
24.
go back to reference Robertson, K. R., Smurzynski, M., Parsons, T. D., et al. (2007). The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS, 21(14), 1915–1921.PubMedCrossRef Robertson, K. R., Smurzynski, M., Parsons, T. D., et al. (2007). The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS, 21(14), 1915–1921.PubMedCrossRef
25.
go back to reference Lichtenstein, K. A., Armon, C., Buchacz, K., et al. (2008). Initiation of antiretroviral therapy at CD4 cell counts >/=350 cells/mm3 does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 47(1), 27–35.PubMedCrossRef Lichtenstein, K. A., Armon, C., Buchacz, K., et al. (2008). Initiation of antiretroviral therapy at CD4 cell counts >/=350 cells/mm3 does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. Journal of Acquired Immune Deficiency Syndromes: JAIDS, 47(1), 27–35.PubMedCrossRef
26.
go back to reference D:A:D Study Group. (2008). Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: A multi-cohort collaboration. Lancet, April, 1417–1426. D:A:D Study Group. (2008). Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: A multi-cohort collaboration. Lancet, April, 1417–1426.
27.
go back to reference Lichtenstein, K. A., Armon, C., Buchacz, K., et al. (2010). Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study. Clinical Infectious Diseases, 51(4), 435–447.CrossRef Lichtenstein, K. A., Armon, C., Buchacz, K., et al. (2010). Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study. Clinical Infectious Diseases, 51(4), 435–447.CrossRef
Metagegevens
Titel
The associations among coping, nadir CD4+ T-cell count, and non-HIV-related variables with health-related quality of life among an ambulatory HIV-positive patient population
Auteurs
Carl Armon
Kenneth Lichtenstein
Publicatiedatum
01-08-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 6/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0017-2

Andere artikelen Uitgave 6/2012

Quality of Life Research 6/2012 Naar de uitgave